Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech

Microbial Challenge Promotes the Regenerative Process of the Injured Central Nervous System of the Medicinal Leech by Inducing the Synthesis of Antimicrobial Peptides in Neurons and Microglia

(2014) D. Schikorski et al.   JOURNAL OF IMMUNOLOGY

The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes

(2013) Françoise Le Marrec-Croq et al.   Clinical & Developmental Immunology

Toll-like receptors and MyD88 adaptors in Mytilus: Complete cds and gene expression levels

(2013) Mylène Toubiana et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Involvement of nitric oxide through endocannabinoids release in microglia activation during the course of CNS regeneration in the medicinal leech

(2013) Karim Arafah et al.   GLIA

SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

(2013) Y.-J. Hou et al.   JOURNAL OF IMMUNOLOGY

Litopenaeus vannamei Sterile-Alpha and Armadillo Motif Containing Protein (LvSARM) Is Involved in Regulation of Penaeidins and antilipopolysaccharide factors

(2013) Pei-Hui Wang et al.   PLoS One

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo

(2012) Xiang Zhou et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A novel myeloid differentiation factor 88 homolog, SpMyD88, exhibiting SpToll-binding activity in the mud crab Scylla paramamosain

(2012) Xin-Cang Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Orange-spotted grouper (Epinephelus coioides) toll-like receptor 22: Molecular characterization, expression pattern and pertinent signaling pathways

(2012) Xu Ding et al.   FISH & SHELLFISH IMMUNOLOGY

Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in Drosophila

(2012) Lorri R. Marek et al.   IMMUNITY

An Evolutionarily Conserved Innate Immunity Protein Interaction Network

(2012) Lesly De Arras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

(2012) Sophie Leow-Dyke et al.   Journal of Neuroinflammation

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei

(2012) Shuang Zhang et al.   PLoS One

MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers

(2012) S. Franzenburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR-4-Dependent and -Independent Mechanisms of Fetal Brain Injury in the Setting of Preterm Birth

(2012) Kelsey Breen et al.   Reproductive Sciences

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

(2011) Manyi Yang et al.   CELL RESEARCH

Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair

(2011) Céline Boidin-Wichlacz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans

(2011) Chieh Chang et al.   DEVELOPMENT

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

(2011) Chiung-Ya Chen et al.   JOURNAL OF CELL BIOLOGY

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes

(2010) Eduardo R Macagno et al.   BMC GENOMICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Characterization and immune function of two intracellular sensors, HmTLR1 and HmNLR, in the injured CNS of an invertebrate

(2010) Virginie Cuvillier-Hot et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

SARM inhibits both TRIF- and MyD88-mediated AP-1 activation

(2010) Jun Peng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

A Unique Feature of Toll/IL-1 Receptor Domain-Containing Adaptor Protein Is Partially Responsible for Lipopolysaccharide Insensitivity in Zebrafish with a Highly Conserved Function of Myd88

(2010) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Amphioxus SARM Involved in Neural Development May Function as a Suppressor of TLR Signaling

(2010) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome

(2010) Ricardo Fernández et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

TIR-containing adaptors in Toll-like receptor signalling

(2009) Kristie A. Jenkins et al.   CYTOKINE

Identification of Critical Residues of the MyD88 Death Domain Involved in the Recruitment of Downstream Kinases

(2009) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Lipopolysaccharide (LPS) Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF- B Activation

(2009) M. P. Sepulcre et al.   JOURNAL OF IMMUNOLOGY

Deciphering the Immune Function and Regulation by a TLR of the Cytokine EMAPII in the Lesioned Central Nervous System Using a Leech Model

(2009) D. Schikorski et al.   JOURNAL OF IMMUNOLOGY

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-κB pathway via MyD88

(2009) Shaochun Yuan et al.   MOLECULAR IMMUNOLOGY

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens

(2008) Vinita S. Chauhan et al.   GLIA

Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled A 42 peptide receptor, in microglial cells

(2008) K. Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evidence for a novel chemotactic C1q domain-containing factor in the leech nerve cord

(2008) Muriel Tahtouh et al.   MOLECULAR IMMUNOLOGY

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons

(2007) Cristian Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human

(2007) Loh Wei-Ching Belinda et al.   MOLECULAR IMMUNOLOGY