Toll-Like Receptors: Regulators of the Immune Response in the Human Gut

Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species

(2018) Glenn Hamonic et al.   CELL AND TISSUE RESEARCH

Endogenous ligands of TLR4 promote unresolving tissue fibrosis: Implications for systemic sclerosis and its targeted therapy

(2018) Swati Bhattacharyya et al.   IMMUNOLOGY LETTERS

Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals

(2017) Mallenahally Kusha Vidya et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Expression of TLR4 in Non-Small Cell Lung Cancer Is Associated with PD-L1 and Poor Prognosis in Patients Receiving Pulmonectomy

(2017) Kaiyuan Wang et al.   Frontiers in Immunology

Probiotics and the Gut Immune System: Indirect Regulation

(2017) Giorgio La Fata et al.   Probiotics and Antimicrobial Proteins

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models

(2016) Xiaorui Zhang et al.   CARBOHYDRATE POLYMERS

Toll-like receptor 2 and type 2 diabetes

(2016) Zahra Sepehri et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The science of vaccine adjuvants: advances in TLR4 ligand adjuvants

(2016) Steven G Reed et al.   CURRENT OPINION IN IMMUNOLOGY

Interaction between gut microbiota and toll-like receptor: from immunity to metabolism

(2016) Jensen H.C. Yiu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

(2016) Leo A. B. Joosten et al.   Nature Reviews Rheumatology

The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function

(2016) Leonie M. Vogt et al.   Journal of Functional Foods

Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

(2016) Feng Wei et al.   Oncotarget

Insights into Soluble Toll-Like Receptor 2 as a Downregulator of Virally Induced Inflammation

(2016) Bethany M. Henrick et al.   Frontiers in Immunology

Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

(2016) Aline Ignacio et al.   Frontiers in Immunology

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases

(2015) Irma Garcia-Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance

(2015) Shiyan Yu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

(2015) C. T. Peterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts

(2015) Xiaohua Yang et al.   HUMAN REPRODUCTION

Interplay of the Gastric PathogenHelicobacter pyloriwith Toll-Like Receptors

(2015) Suneesh Kumar Pachathundikandi et al.   Biomed Research International

How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology

(2015) Simona Frosali et al.   Journal of Immunology Research

Association of TLR5 Gene Polymorphisms in Ulcerative Colitis Patients of North India and Their Role in Cytokine Homeostasis

(2015) Naresh Kumar Meena et al.   PLoS One

Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort

(2015) Steffen Bank et al.   PLoS One

Regulation of innate immune responses by transmembrane interactions: Lessons from the TLR family

(2014) Eliran Moshe Reuven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Flagellin A Toll-Like Receptor 5 Agonist as an Adjuvant in Chicken Vaccines

(2014) Shishir Kumar Gupta et al.   Clinical and Vaccine Immunology

Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia

(2014) Ana Moraga et al.   FASEB JOURNAL

Toll-like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons

(2014) Labchan Rajbhandari et al.   GLIA

Biological role of Toll-like receptor-4 in the brain

(2014) Teresa Trotta et al.   JOURNAL OF NEUROIMMUNOLOGY

Toll-Like Receptor 2 Activation by β2→1-Fructans Protects Barrier Function of T84 Human Intestinal Epithelial Cells in a Chain Length–Dependent Manner

(2014) Leonie M. Vogt et al.   JOURNAL OF NUTRITION

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells

(2014) Mariagrazia Valentini et al.   Journal of Immunology Research

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway

(2013) Jingjing Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Use of Lentinan for Treating Gastric Cancer

(2013) Kenji Ina et al.   Anti-Cancer Agents in Medicinal Chemistry

Long chain fatty acids and gene expression in inflammation and immunity

(2013) Philip C. Calder   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium

(2013) A. Nazli et al.   JOURNAL OF IMMUNOLOGY

Immune Modulation by Different Types of β2→1-Fructans Is Toll-Like Receptor Dependent

(2013) Leonie Vogt et al.   PLoS One

Multifunctional fructans and raffinose family oligosaccharides

(2013) Wim Van den Ende   Frontiers in Plant Science

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB

(2012) Hyung Jin Choi et al.   MOLECULAR BIOLOGY REPORTS

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Innate immunity in the small intestine

(2011) Rebeca Santaolalla et al.   CURRENT OPINION IN GASTROENTEROLOGY

MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties

(2011) S. Wang et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine

(2010) Amlan Biswas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like receptors in inflammatory bowel diseases: A decade later

(2010) Elke Cario   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

(2010) Y. Guan et al.   JOURNAL OF IMMUNOLOGY

Expression and regulation of toll-like receptors in cerebral endothelial cells

(2010) Péter Nagyőszi et al.   NEUROCHEMISTRY INTERNATIONAL

A truncated lipoglycan from mycobacteria with altered immunological properties

(2010) H. L. Birch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-α secretion by macrophage-like cells

(2009) S. L. Zunt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

(2009) Michael B Fessler et al.   CURRENT OPINION IN LIPIDOLOGY

TLR2-independent induction and regulation of chronic intestinal inflammation

(2009) Olivier Boulard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

(2009) Arunan S. Vamadevan et al.   Innate Immunity

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porin of Shigella dysenteriae directly promotes Toll-like receptor 2-mediated CD4+ T cell survival and effector function

(2009) Amlan Biswas et al.   MOLECULAR IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells

(2009) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory

(2008) Avi Levin et al.   WORLD JOURNAL OF GASTROENTEROLOGY