Role of CD4+Cytotoxic T Lymphocytes in the Control of Viral Diseases and Cancer

EBV Latent Membrane Proteins (LMPs) 1 and 2 as Immunotherapeutic Targets: LMP-Specific CD4+ Cytotoxic T Cell Recognition of EBV-Transformed B Cell Lines

(2014) T. A. Haigh et al.   JOURNAL OF IMMUNOLOGY

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display

(2010) C. S. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells

(2009) H. M. Long et al.   BLOOD

Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

(2009) H. E. Heslop et al.   BLOOD

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

(2009) Deborah M. Brown et al.   CELLULAR IMMUNOLOGY

Adoptive immunotherapy of cancer using CD4+ T cells

(2009) Pawel Muranski et al.   CURRENT OPINION IN IMMUNOLOGY

Epstein–Barr virus and multiple sclerosis

(2009) Marco Salvetti et al.   CURRENT OPINION IN NEUROLOGY

Therapeutic HPV DNA vaccines

(2009) Archana Monie et al.   Expert Review of Vaccines

Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages

(2009) N. Zheng et al.   JOURNAL OF VIROLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Identification of a Human Cyclin D1-Derived Peptide that Induces Human Cytotoxic CD4 T Cells

(2009) Tao Dao et al.   PLoS One

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production

(2009) H. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of EBV-Latent Membrane Protein 1-Specific MHC Class II-Restricted T-Cell Responses against Natural Killer Lymphoma Cells

(2008) H. Kobayashi et al.   CANCER RESEARCH

The History of Tumor Virology

(2008) R. T. Javier et al.   CANCER RESEARCH

Epstein-Barr virus nuclear antigen 1-specific CD4+T cells directly kill Epstein-Barr virus-carrying natural killer and T cells

(2008) Ayako Demachi-Okamura et al.   CANCER SCIENCE

Cytotoxic human CD4+ T cells

(2008) Pablo J van de Berg et al.   CURRENT OPINION IN IMMUNOLOGY

Novel mechanisms of suppressor activity exhibited by cytotoxic regulatory T cell lines, HOZOT

(2008) Motoyuki Suzuki et al.   EXPERIMENTAL HEMATOLOGY

Adoptive cell therapy against EBV-related malignancies: a survey of clinical results

(2008) Anna Merlo et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Th17 cells: a new fate for differentiating helper T cells

(2008) Zhi Chen et al.   IMMUNOLOGIC RESEARCH

Multiple roles for CD4+T cells in anti-tumor immune responses

(2008) Richard Kennedy et al.   IMMUNOLOGICAL REVIEWS

Patients with Epstein Barr virus-positive lymphomas have decreased CD4+T-cell responses to the viral nuclear antigen 1

(2008) Kevin N. Heller et al.   INTERNATIONAL JOURNAL OF CANCER

Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-γ T cell responses

(2008) Ann M. Moormann et al.   INTERNATIONAL JOURNAL OF CANCER

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

(2008) Jan D. Lünemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

(2008) Naomi N. Hunder et al.   NEW ENGLAND JOURNAL OF MEDICINE