Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation

(2017) Natalie J. Serkova   Frontiers in Immunology

Gold nanoparticles-based SPECT/CT imaging probe targeting for vulnerable atherosclerosis plaques

(2016) Xiao Li et al.   BIOMATERIALS

Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis

(2016) C. Weber et al.   CANCER RESEARCH

Smart fluorescent probes for imaging macrophage activity

(2016) Antonio Fernández et al.   CHEMICAL SOCIETY REVIEWS

Imaging Atherosclerosis

(2016) Jason M. Tarkin et al.   CIRCULATION RESEARCH

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer

(2016) Xiu Juan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy

(2016) Alba Alfonso-García et al.   JOURNAL OF BIOMEDICAL OPTICS

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis

(2016) Sara McArdle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Reverse Migration of Neutrophils: Where, When, How, and Why?

(2016) Sussan Nourshargh et al.   TRENDS IN IMMUNOLOGY

A Zebrafish Live Imaging Model Reveals Differential Responses of Microglia Toward Glioblastoma Cells In Vivo

(2016) Lloyd Hamilton et al.   Zebrafish

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

(2016) Xiao-Ming Meng et al.   Cell Death & Disease

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors

(2016) Ji Bak Kim et al.   Scientific Reports

In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging

(2016) Joseph M. Szulczewski et al.   Scientific Reports

Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice

(2016) Clément Ricard et al.   Scientific Reports

A method for long-term live imaging of tissue macrophages in adipose tissue explants

(2015) Martin Gericke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Imaging Macrophage and Hematopoietic Progenitor Proliferation in AtherosclerosisNovelty and Significance

(2015) Yu-Xiang Ye et al.   CIRCULATION RESEARCH

Xenopus: An in vivo model for imaging the inflammatory response following injury and bacterial infection

(2015) Roberto Paredes et al.   DEVELOPMENTAL BIOLOGY

New techniques of intravessel imaging in coronary atherosclerosis

(2015) F. Prati et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Elucidation of monocyte/macrophage dynamics and function by intravital imaging

(2015) Rejane Rua et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vertebrate Epidermal Cells Are Broad-Specificity Phagocytes That Clear Sensory Axon Debris

(2015) J. P. Rasmussen et al.   JOURNAL OF NEUROSCIENCE

Optimizing FDG-PET/CT imaging of inflammation in atherosclerosis

(2015) Antti Saraste et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Unknown

(2015) Gabriella Leung et al.   MOLECULAR MEDICINE

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

In Vivo Fluorescence Microscopy: Lessons From Observing Cell Behavior in Their Native Environment

(2015) Myunghwan Choi et al.   PHYSIOLOGY

Visualized macrophage dynamics and significance of S100A8 in obese fat

(2015) Ryohei Sekimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

(2015) Shuang Wang et al.   Oncotarget

In vivo Quantification of the Structural Changes of Collagens in a Melanoma Microenvironment with Second and Third Harmonic Generation Microscopy

(2015) Pei-Chun Wu et al.   Scientific Reports

Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy

(2015) Tong-Hong Wang et al.   Scientific Reports

Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer

(2015) Xianlei Sun et al.   Theranostics

Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation

(2015) Hannah Dueck et al.   GENOME BIOLOGY

Intravital and Whole-Organ Imaging Reveals Capture of Melanoma-Derived Antigen by Lymph Node Subcapsular Macrophages Leading to Widespread Deposition on Follicular Dendritic Cells

(2015) Federica Moalli et al.   Frontiers in Immunology

Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules

(2015) Chih-Wei Hsu et al.   PLoS One

Establishment of Green Fluorescent Protein and Firefly Luciferase Expressing Mouse Primary Macrophages for In Vivo Bioluminescence Imaging

(2015) Jukka Pajarinen et al.   PLoS One

Development of optical probes for in vivo imaging of polarized macrophages during foreign body reactions

(2014) David W. Baker et al.   Acta Biomaterialia

A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation

(2014) Nam-Young Kang et al.   CHEMICAL COMMUNICATIONS

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

(2014) Sebastien Tauzin et al.   JOURNAL OF CELL BIOLOGY

Imaging macrophages with nanoparticles

(2014) Ralph Weissleder et al.   NATURE MATERIALS

PET imaging of inflammation in atherosclerosis

(2014) Jason M. Tarkin et al.   Nature Reviews Cardiology

Multiplex Cell and Lineage Tracking with Combinatorial Labels

(2014) Karine Loulier et al.   NEURON

In Vivo Detection of Macrophage Recruitment in Hind-Limb Ischemia Using a Targeted Near-Infrared Fluorophore

(2014) Jung Sun Yoo et al.   PLoS One

In Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds

(2014) Mathieu P. Rodero et al.   PLoS One

In Vivo Imaging of Tissue-Remodeling Activity Involving Infiltration of Macrophages by a Systemically Administered Protease-Activatable Probe in Colon Cancer Tissues

(2014) Nobuhiko Onda et al.   Translational Oncology

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner

(2014) Alexander Birbrair et al.   Stem Cell Research & Therapy

Local apoptosis mediates clearance of macrophages from resolving inflammation in mice

(2013) E. L. Gautier et al.   BLOOD

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Imaging cell biology in live animals: Ready for prime time

(2013) Roberto Weigert et al.   JOURNAL OF CELL BIOLOGY

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Protective effects of matrix metalloproteinase-12 following corneal injury

(2013) M. F. Chan et al.   JOURNAL OF CELL SCIENCE

Catecholamine Stress Alters Neutrophil Trafficking and Impairs Wound Healing by β 2 -Adrenergic Receptor–Mediated Upregulation of IL-6

(2013) Min-Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The promise of single-cell sequencing

(2013) James Eberwine et al.   NATURE METHODS

Surgical implantation of an abdominal imaging window for intravital microscopy

(2013) Laila Ritsma et al.   Nature Protocols

The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy

(2013) Serge Mostowy et al.   PLoS Pathogens

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

(2013) Driss El Kebir et al.   Frontiers in Immunology

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Imaging macrophage development and fate in atherosclerosis and myocardial infarction

(2012) Filip K Swirski et al.   IMMUNOLOGY AND CELL BIOLOGY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals

(2012) Jun Ki Kim et al.   Nature Protocols

Time course of histomorphological changes in adipose tissue upon acute lipoatrophy

(2012) I. Murano et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Embryonic stem cell-derived M2-like macrophages delay cutaneous wound healing

(2012) Daniela Dreymueller et al.   WOUND REPAIR AND REGENERATION

Imaging granularity of leukocytes with third harmonic generation microscopy

(2012) Cheng-Kun Tsai et al.   Biomedical Optics Express

Imaging morphodynamics of human blood cells in vivo with video-rate third harmonic generation microscopy

(2012) Chien-Kuo Chen et al.   Biomedical Optics Express

Wound Macrophages as Key Regulators of Repair

(2011) Samielle K. Brancato et al.   AMERICAN JOURNAL OF PATHOLOGY

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

(2011) Tom M. Piscaer et al.   ARTHRITIS AND RHEUMATISM

89Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging

(2011) Edmund J. Keliher et al.   BIOCONJUGATE CHEMISTRY

Real time monitoring of biomaterial-mediated inflammatory responses via macrophage-targeting NIR nanoprobes

(2011) Jun Zhou et al.   BIOMATERIALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice

(2011) Rita Mirza et al.   CYTOKINE

Inflammation and wound healing: the role of the macrophage

(2011) Timothy J. Koh et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Comparison of human optimized bacterial luciferase, firefly luciferase, and green fluorescent protein for continuous imaging of cell culture and animal models

(2011) Dan M. Close et al.   JOURNAL OF BIOMEDICAL OPTICS

Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy

(2011) Samir Awasthi et al.   Journal of Biophotonics

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

(2011) E. T. Roussos et al.   JOURNAL OF CELL SCIENCE

Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish

(2011) S. K. Yoo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

(2011) Susan E. Quaggin et al.   KIDNEY INTERNATIONAL

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

Label-Free 3D Visualization of Cellular and Tissue Structures in Intact Muscle with Second and Third Harmonic Generation Microscopy

(2011) Markus Rehberg et al.   PLoS One

Label-free live brain imaging and targeted patching with third-harmonic generation microscopy

(2011) S. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish

(2011) Caroline Gray et al.   THROMBOSIS AND HAEMOSTASIS

The uptake and intracellular fate of a series of different surface coated quantum dots in vitro

(2011) Martin J.D. Clift et al.   TOXICOLOGY

In vivo optical virtual biopsy of human oral mucosa with harmonic generation microscopy

(2011) Ming-Rung Tsai et al.   Biomedical Optics Express

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Ex vivo imaging and quantification of liver fibrosis using second-harmonic generation microscopy

(2010) Tzu-Lin Sun et al.   JOURNAL OF BIOMEDICAL OPTICS

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

(2010) Savita Khanna et al.   PLoS One

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

(2010) Yi Feng et al.   PLOS BIOLOGY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH

In Vivo Virtual Biopsy of Human Skin by Using Noninvasive Higher Harmonic Generation Microscopy

(2009) Szu-Yu Chen et al.   IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Advantages of Nanoparticles for PET

(2009) M. J. Welch et al.   JOURNAL OF NUCLEAR MEDICINE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

(2008) R. A. Dean et al.   BLOOD

Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis

(2008) Farouc A. Jaffer et al.   CIRCULATION

Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment

(2008) Paolo P. Provenzano et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cell tracking with optical imaging

(2008) Elizabeth J. Sutton et al.   EUROPEAN RADIOLOGY

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

(2008) Satoshi Nishimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

(2008) Min-Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasmonic Intravascular Photoacoustic Imaging for Detection of Macrophages in Atherosclerotic Plaques

(2008) Bo Wang et al.   NANO LETTERS

Intravital imaging of metastatic behavior through a mammary imaging window

(2008) Dmitriy Kedrin et al.   NATURE METHODS

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

(2007) Matthias Nahrendorf et al.   CIRCULATION