Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of Psoriasis

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

(2018) Akira Shibata et al.   BIOCHEMICAL PHARMACOLOGY

Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders

(2018) Matteo Dal Prà et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of carbazole carboxamides as novel RORγt inverse agonists

(2018) Yafei Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints

(2018) Marie-Astrid Boutet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Psoriasis: A STAT3-Centric View

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rates of latent tuberculosis infection in patients treated with TNF inhibitors for psoriasis: a retrospective chart review

(2018) Erica B. Lee et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Change over time in the rates of adverse events in patients receiving systemic therapy for psoriasis: A cohort study

(2018) Miguel Angel Descalzo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis

(2017) Lluís Puig   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oral administration of a novel RORγt antagonist attenuates psoriasis-like skin lesion of two independent mouse models through neutralization of IL-17

(2017) Mikiro Takaishi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Pathogenesis of psoriasis and development of treatment

(2017) Eisaku Ogawa et al.   JOURNAL OF DERMATOLOGY

Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm

(2017) I. Belinchón et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Contribution of In Vivo and Organotypic 3D Models to Understanding the Role of Macrophages and Neutrophils in the Pathogenesis of Psoriasis

(2017) Isabelle Lorthois et al.   MEDIATORS OF INFLAMMATION

Healthcare costs in psoriasis and psoriasis sub-groups over time following psoriasis diagnosis

(2017) Sarah Al Sawah et al.   JOURNAL OF MEDICAL ECONOMICS

Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

(2017) Elodie Couderc et al.   PLoS One

The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function

(2017) Carolina M. Pfaff et al.   Scientific Reports

Pathogenese der Psoriasis vulgaris

(2016) K. Schäkel et al.   HAUTARZT

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

(2016) Renu Jain et al.   IMMUNITY

IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis

(2016) Junfeng Zhang et al.   JOURNAL OF IMMUNOLOGY

Keratinocyte-Derived IL-17E Contributes to Inflammation in Psoriasis

(2016) Luisa Senra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

(2016) Bradley N Martin et al.   NATURE IMMUNOLOGY

Erratum: Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

(2016) Junjian Wang et al.   NATURE MEDICINE

Psoriasis

(2016) Jacqueline E. Greb et al.   Nature Reviews Disease Primers

Psoriasis: classical and emerging comorbidities

(2015) Maria de Fátima Santos Paim de Oliveira et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

T cell responses in psoriasis and psoriatic arthritis

(2015) Marco Diani et al.   AUTOIMMUNITY REVIEWS

The global burden of psoriatic skin disease

(2015) K.L. Goff et al.   BRITISH JOURNAL OF DERMATOLOGY

ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes

(2015) Laura A. Solt et al.   ENDOCRINOLOGY

Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis

(2015) Kristian Reich et al.   EXPERIMENTAL DERMATOLOGY

Secukinumab for treating plaque psoriasis

(2015) Brooke Rothstein et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Digoxin ameliorates autoimmune arthritis via suppression of Th17 differentiation

(2015) Jennifer Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The immunogenetics of Psoriasis: A comprehensive review

(2015) Jamie L. Harden et al.   JOURNAL OF AUTOIMMUNITY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Targeting Th17 Cells with Small Molecules and Small Interference RNA

(2015) Hui Lin et al.   MEDIATORS OF INFLAMMATION

Economic Burden of Psoriasis in the United States

(2015) Elizabeth A. Brezinski et al.   JAMA Dermatology

Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation

(2014) Seung-ye Baek et al.   ACTA PHARMACOLOGICA SINICA

The pathophysiological role of dendritic cell subsets in psoriasis

(2014) Tae-Gyun Kim et al.   BMB Reports

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Pharmacologic Inhibition of ROR t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

(2014) J. Skepner et al.   JOURNAL OF IMMUNOLOGY

Impact of psoriasis severity on family income and quality of life

(2014) T. Hawro et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways

(2013) JIUMAO LIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

In Vivo Induction of Cutaneous Inflammation Results in the Accumulation of Extracellular Trap-Forming Neutrophils Expressing RORγt and IL-17

(2013) Romy R.M.C Keijsers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions

(2013) Roderick J. Hay et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway

(2013) Yonghan He et al.   PLoS One

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

(2012) Naresh Kumar et al.   ACS Chemical Biology

Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice

(2012) Eléonore Beurel et al.   BIOLOGICAL PSYCHIATRY

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Depression and the risk of psoriasis in US women

(2012) P.L. Dominguez et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

(2011) Saori Fujita-Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Increased interleukin-23 receptor+ T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus

(2011) Hathaipat Puwipirom et al.   ARTHRITIS RESEARCH & THERAPY

A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)

(2010) Yongjun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells

(2010) C. Schirmer et al.   BLOOD

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines of care for the management of psoriasis and psoriatic arthritis

(2009) Alan Menter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY