A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs

(2018) Soonsil Hyun et al.   Chemical Science

Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation

(2018) Xiaodong Shi et al.   Chemical Science

Drug-induced co-assembly of albumin/catalase as smart nano-theranostics for deep intra-tumoral penetration, hypoxia relieve, and synergistic combination therapy

(2017) Qian Chen et al.   JOURNAL OF CONTROLLED RELEASE

Structural Basis of Inhibition of ERα-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides

(2017) Mingsheng Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning

(2017) Yuan Tian et al.   Chemical Science

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

(2016) Philipp M. Cromm et al.   ACS Chemical Biology

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

(2016) Kuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction

(2016) Thomas E. Speltz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crosslinked Aspartic Acids as Helix-Nucleating Templates

(2016) Hui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy

(2016) Chao Liang et al.   CHEMICAL SOCIETY REVIEWS

Nitrogen Arylation for Macrocyclization of Unprotected Peptides

(2016) Guillaume Lautrette et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipopolyplexes

(2016) Philipp Michael Klein et al.   Nanoscale

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

(2016) Yuan Tian et al.   Chemical Science

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells

(2015) James W. Checco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA

(2015) Feng Yin et al.   Theranostics

Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer Cells

(2015) Yuhuan Li et al.   Journal of Cancer

A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery

(2014) Jingguo Li et al.   ADVANCED MATERIALS

Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription

(2014) Sangmok Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stitched α-Helical Peptides via Bis Ring-Closing Metathesis

(2014) Gerard J. Hilinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Diaminodiacid-Based Solid-Phase Synthesis of Peptide Disulfide Bond Mimics

(2013) Hong-Kui Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible chemoselective tagging and functionalization of methionine containing peptides

(2013) Jessica R. Kramer et al.   CHEMICAL COMMUNICATIONS

Dynamic Amphiphile Libraries To Screen for the “Fragrant” Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts

(2013) Charlotte Gehin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell entry of cell penetrating peptides: tales of tails wagging dogs

(2012) Arwyn T. Jones et al.   JOURNAL OF CONTROLLED RELEASE

High-Throughput Profiling of Peptide–RNA Interactions Using Peptide Microarrays

(2012) Jaeyoung Pai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

(2012) Helerin Margus et al.   MOLECULAR THERAPY

The intracellular plasmid DNA localization of cationic reducible cholesterol-disulfide lipids

(2011) Ruilong Sheng et al.   BIOMATERIALS

Survivin siRNA Inhibits Gastric Cancer in Nude Mice

(2011) Zhao Wenying et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

(2011) Federico Mingozzi et al.   NATURE REVIEWS GENETICS

RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo

(2011) S. Hendruschk et al.   NEURO-ONCOLOGY

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Engineering RNA for Targeted siRNA Delivery and Medical Application

(2010) Peixuan Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid-based systemic delivery of siRNA

(2009) Yu-Cheng Tseng et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

(2009) Tamaki Endoh et al.   ADVANCED DRUG DELIVERY REVIEWS

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth

(2009) L. Crombez et al.   NUCLEIC ACIDS RESEARCH

Gold nanoparticles in delivery applications☆

(2008) P GHOSH et al.   ADVANCED DRUG DELIVERY REVIEWS

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY