Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice

Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis

(2018) Jie Tao et al.   Frontiers in Immunology

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

(2017) Benjamin A. Olenchock et al.   IMMUNITY

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

(2017) Ian A. Bettencourt et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat

(2017) David Long et al.   Scientific Reports

Sirt6 regulates dendritic cell differentiation, maturation, and function

(2016) Denise Lasigliè et al.   Aging-US

Metabolic Signaling Drives IFN-γ

(2016) Peter J. Siska et al.   Cell Metabolism

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

(2016) Xianfeng Wang et al.   PLoS One

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

(2015) Jessica L. Feldman et al.   BIOCHEMISTRY

Sirtuin regulation in aging and injury

(2015) Ninu Poulose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

The Cellular and Molecular Basis of Translational Immunometabolism

(2015) Giuseppe Danilo Norata et al.   IMMUNITY

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

(2015) Anna B. Owczarczyk et al.   JOURNAL OF IMMUNOLOGY

Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+T cells through IL-12 and TGF-β1

(2015) Guangwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis

(2014) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Reactivation of Multiple Viruses in Patients with Sepsis

(2014) Andrew H. Walton et al.   PLoS One

Septic Shock: On the Importance of Being Tolerant

(2013) Ruslan Medzhitov   IMMUNITY

Sirtuin deacylases: a molecular link between metabolism and immunity

(2013) Nicolas Preyat et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Polarizing Macrophages through Reprogramming of Glucose Metabolism

(2012) Julianna Blagih et al.   Cell Metabolism

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SIRT1 Regulates Dendritic Development in Hippocampal Neurons

(2012) Juan F. Codocedo et al.   PLoS One

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Metabolic signals regulate SIRT1 expression

(2011) Angeliki Chalkiadaki et al.   EMBO REPORTS

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endotoxin Tolerance Impairs IL-1 Receptor-Associated Kinase (IRAK) 4 and TGF-β-activated Kinase 1 Activation, K63-linked Polyubiquitination and Assembly of IRAK1, TNF Receptor-associated Factor 6, and IκB Kinase γ and Increases A20 Expression

(2011) Yanbao Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

(2011) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis

(2010) Barbara K. Yoza et al.   CYTOKINE

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

GAPDH mediates nitrosylation of nuclear proteins

(2010) Michael D. Kornberg et al.   NATURE CELL BIOLOGY

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

(2009) Xiaoping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting

(2009) A. D. Wells   JOURNAL OF IMMUNOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Differential Role for CD80 and CD86 in the Regulation of the Innate Immune Response in Murine Polymicrobial Sepsis

(2009) Anna Nolan et al.   PLoS One

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

Gene-specific control of the TLR-induced inflammatory response

(2008) Simmie L. Foster et al.   CLINICAL IMMUNOLOGY

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE