Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

Expansion of human γδ T cells for adoptive immunotherapy using a bisphosphonate prodrug

(2018) Yoshimasa Tanaka et al.   CANCER SCIENCE

EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances γδT-cell-mediated cytotoxicity via TCR and NKG2D

(2018) Yu-mei Dai et al.   IMMUNOLOGY

Frequency of occurrence of HIV-1 dual infection in a Belgian MSM population

(2018) Laura Hebberecht et al.   PLoS One

Dual infection of the central nervous system caused by Cryptococcus and Toxoplasma in a patient with AIDS: a case report and literature review

(2018) Jose Armando Gonzales Zamora   ACTA CLINICA BELGICA

CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection

(2018) Pádraic J. Dunne et al.   Frontiers in Immunology

Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults

(2018) Lucía Pastor et al.   Frontiers in Immunology

Innate and adaptive T cells in influenza disease

(2018) Simone Nüssing et al.   Frontiers of Medicine

Interleukin-18 activates Vγ9Vδ2+ T cells from HIV-positive individuals: recovering the response to phosphoantigen

(2017) Alanna S. Murday et al.   IMMUNOLOGY

Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells

(2017) Zakia Djaoud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset AttenuatesMycobacterium tuberculosisInfection in Nonhuman Primates

(2017) Arwa Qaqish et al.   JOURNAL OF IMMUNOLOGY

Protective role of γδ T cells in cigarette smoke and influenza infection

(2017) M J Hong et al.   Mucosal Immunology

Thymic Determinants of γδ T Cell Differentiation

(2017) Miguel Muñoz-Ruiz et al.   TRENDS IN IMMUNOLOGY

The Ambiguous Role of γδ T Lymphocytes in Antitumor Immunity

(2017) Guranda Chitadze et al.   TRENDS IN IMMUNOLOGY

Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine

(2017) David Goldeck et al.   VACCINE

Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health?

(2017) Joseph A. McBride et al.   PLoS Pathogens

Potential Role of Vδ2+ γδ T Cells in Regulation of Immune Activation in Primary HIV Infection

(2017) Nupur Bhatnagar et al.   Frontiers in Immunology

Epstein–Barr Virus-Specific Immune Control by Innate Lymphocytes

(2017) Christian Münz   Frontiers in Immunology

Immune-mediated syndromes following intravenous bisphosphonate therapy

(2017) Noa Markovits et al.   INFLAMMOPHARMACOLOGY

Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

(2017) Maria Raffaella Zocchi et al.   OncoImmunology

Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation

(2017) Mohanad H. Nada et al.   Journal for ImmunoTherapy of Cancer

Age dependent differences in the kinetics of γδ T cells after influenza vaccination

(2017) Ulrik Stervbo et al.   PLoS One

Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells

(2017) Martine J. Kallemeijn et al.   Scientific Reports

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

(2017) Prasanna Jagannathan et al.   Scientific Reports

Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug

(2017) Yoshimasa Tanaka et al.   Scientific Reports

Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection

(2017) Huaqing Zhong et al.   Scientific Reports

γδT Cells and Related Diseases

(2016) Han Lu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

NKT cell subsets as key participants in liver physiology and pathology

(2016) Keya Bandyopadhyay et al.   Cellular & Molecular Immunology

Human γδT-cell subsets and their involvement in tumor immunity

(2016) Dang Wu et al.   Cellular & Molecular Immunology

Targeting Cancer Cells with a Bisphosphonate Prodrug

(2016) Kenji Matsumoto et al.   ChemMedChem

Protective immune responses of major Vγ2Vδ2 T-cell subset in M. tuberculosis infection

(2016) Zheng W. Chen   CURRENT OPINION IN IMMUNOLOGY

IL-17A–producing resident memory γδ T cells orchestrate the innate immune response to secondary oralListeria monocytogenesinfection

(2016) Pablo A. Romagnoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γδ T cells in cancer immunotherapy

(2016) Chang Zou et al.   Oncotarget

Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity

(2016) Yoav Bauman et al.   Oncotarget

Functional dichotomy of Vδ2 γδ T cells in chronic hepatitis C virus infections: role in cytotoxicity but not for IFN-γ production

(2016) Wenwei Yin et al.   Scientific Reports

Loss of Intra-Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV-Infected Women

(2015) Natasa Strbo et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

Liver natural killer cells: subsets and roles in liver immunity

(2015) Hui Peng et al.   Cellular & Molecular Immunology

IL-17A–Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver

(2015) Meru Sheel et al.   JOURNAL OF IMMUNOLOGY

Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood

(2015) Lila A. Farrington et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1-Induced Impairment of Dendritic Cell Cross Talk with γδ T Lymphocytes

(2015) Marco Cardone et al.   JOURNAL OF VIROLOGY

Increased Frequencies of Circulating IFN-γ-Producing Vδ1+and Vδ2+γδ T Cells in Patients with Asymptomatic Persistent Hepatitis B Virus Infection

(2015) Melissa J. Conroy et al.   VIRAL IMMUNOLOGY

Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells

(2015) Christelle Harly et al.   Frontiers in Immunology

γδ T Cells in HIV Disease: Past, Present, and Future

(2015) C. David Pauza et al.   Frontiers in Immunology

Enhanced Functions of Peripheral γδ T Cells in Chronic Hepatitis B Infection during Interferon α Treatment In Vivo and In Vitro

(2015) Min Chen et al.   PLoS One

Primary and Chronic HIV Infection Differently Modulates Mucosal Vδ1 and Vδ2 T-Cells Differentiation Profile and Effector Functions

(2015) Eleonora Cimini et al.   PLoS One

IL-21R Signaling Suppresses IL-17+ Gamma Delta T Cell Responses and Production of IL-17 Related Cytokines in the Lung at Steady State and After Influenza A Virus Infection

(2015) Emily K. Moser et al.   PLoS One

Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease

(2014) Zheng Xiang et al.   CANCER CELL

Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials

(2014) Abrar K Thabit et al.   EXPERT OPINION ON PHARMACOTHERAPY

The protective effect of CD40 ligand-CD40 signalling is limited during the early phase ofPlasmodiuminfection

(2014) Shin-Ichi Inoue et al.   FEBS LETTERS

Vγ2Vδ2 T-cell co-stimulation increases natural killer cell killing of monocyte-derived dendritic cells

(2014) Cristiana Cairo et al.   IMMUNOLOGY

Tracing innate immune defences along the path of Listeria monocytogenes infection

(2014) Tim Regan et al.   IMMUNOLOGY AND CELL BIOLOGY

γδ T Cells and Their Potential for Immunotherapy

(2014) Yan-Ling Wu et al.   International Journal of Biological Sciences

IL-17A Produced by    T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver

(2014) S. Hamada et al.   JOURNAL OF IMMUNOLOGY

γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8+T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance

(2014) Xiaohui Kong et al.   JOURNAL OF IMMUNOLOGY

γδ T cells and CD14+ Monocytes Are Predominant Cellular Sources of Cytokines and Chemokines Associated With Severe Malaria

(2014) Danielle I. Stanisic et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of γδT cells in naïve and HIV-infected chimpanzees and their responses to T-cell activatorsin vitro

(2014) Vida L. Hodara et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma

(2014) Lee Fah Yap et al.   JOURNAL OF PATHOLOGY

Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells

(2014) Martin Wilhelm et al.   Journal of Translational Medicine

Essential role for autophagy in the maintenance of immunological memory against influenza infection

(2014) Min Chen et al.   NATURE MEDICINE

Loss and dysfunction of V 2+    T cells are associated with clinical tolerance to malaria

(2014) P. Jagannathan et al.   Science Translational Medicine

New year, new look, new content

(2014) Ignatius TS Yu et al.   HONG KONG MEDICAL JOURNAL

γδ T Lymphocytes as a First Line of Immune Defense: Old and New Ways of Antigen Recognition and Implications for Cancer Immunotherapy

(2014) Alessandro Poggi et al.   Frontiers in Immunology

Human Vδ2+ γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells

(2014) Andreea Petrasca et al.   Frontiers in Immunology

γδ T cells for cancer immunotherapy

(2014) Jonathan PH Fisher et al.   OncoImmunology

The Potential Role of CD16+ Vγ2Vδ2 T Cell-Mediated Antibody-Dependent Cell-Mediated Cytotoxicity in Control of HIV Type 1 Disease

(2013) Xuan He et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Critical role of butyrophilin 3A1 in presenting prenyl pyrophosphate antigens to human γδ T cells

(2013) Dieter Kabelitz   Cellular & Molecular Immunology

A fat story—antigen presentation by butyrophilin 3A1 to γδ T cells

(2013) Charlotte Esser   Cellular & Molecular Immunology

Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain

(2013) Takamichi Izumi et al.   CYTOTHERAPY

Combination of Epstein-Barr virus nuclear antigen 1, 3 and lytic antigen BZLF1 peptide pools allows fast and efficient stimulation of Epstein-Barr virus-specific T cells for adoptive immunotherapy

(2013) Yingying Wang et al.   CYTOTHERAPY

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

(2013) Crystal Y. Chen et al.   PLoS Pathogens

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

Diversity of γδ T-cell antigens

(2012) Willi K Born et al.   Cellular & Molecular Immunology

Understanding the complexity of γδ T-cell subsets in mouse and human

(2012) Dick J. Pang et al.   IMMUNOLOGY

Enhanced Peripheral γδT Cells Cytotoxicity Potential in Patients with HBV-Associated Acute-On-Chronic Liver Failure Might Contribute to the Disease Progression

(2012) Min Chen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity

(2012) Nadia Caccamo et al.   PLoS One

Enhancement of dendritic cell activation via CD40 ligand-expressing γδ T cells is responsible for protective immunity toPlasmodiumparasites

(2012) Shin-Ichi Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

(2012) J.J. Ott et al.   VACCINE

HIV envelope-mediated, CCR5/ 4 7-dependent killing of CD4-negative    T cells which are lost during progression to AIDS

(2011) H. Li et al.   BLOOD

Control of Plasmodium falciparum erythrocytic cycle:    T cells target the red blood cell-invasive merozoites

(2011) G. Costa et al.   BLOOD

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

γδ T-APCs: a novel tool for immunotherapy?

(2011) Bernhard Moser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulation of γδ T cell responses by TLR ligands

(2011) Daniela Wesch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Searching for “signal 2”: costimulation requirements of γδ T cells

(2011) Julie C. Ribot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

γδT Cells Cross-Link Innate and Adaptive Immunity inMycobacterium tuberculosisInfection

(2011) Serena Meraviglia et al.   Clinical & Developmental Immunology

Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity

(2011) Bhawna Poonia et al.   CYTOTHERAPY

The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

(2011) Wenwei Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mapping the Transcriptional Machinery of the IL-8 Gene in Human Bronchial Epithelial Cells

(2011) V. Bezzerri et al.   JOURNAL OF IMMUNOLOGY

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted    T Cells in the Normal Murine Repertoire

(2011) M. Dieude et al.   JOURNAL OF IMMUNOLOGY

Type 1 Responses of Human V 9V 2 T Cells to Influenza A Viruses

(2011) G. Qin et al.   JOURNAL OF VIROLOGY

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular aspects of epithelial γδ T cell regulation

(2011) Deborah A. Witherden et al.   TRENDS IN IMMUNOLOGY

Mechanisms underlying    T-cell subset perturbations in SIV-infected Asian rhesus macaques

(2010) L. D. Harris et al.   BLOOD

Human    T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

(2010) A. Maniar et al.   BLOOD

The Plasticity of γδ T Cells: Innate Immunity, Antigen Presentation and New Immunotherapy

(2010) Rita Casetti et al.   Cellular & Molecular Immunology

Interleukin-17 and its expanding biological functions

(2010) Sheng Xu et al.   Cellular & Molecular Immunology

IL-17A-Producing   T Cells Promote CTL Responses against Listeria monocytogenes Infection by Enhancing Dendritic Cell Cross-Presentation

(2010) S. Xu et al.   JOURNAL OF IMMUNOLOGY

Infectious Mononucleosis

(2010) Katherine Luzuriaga et al.   NEW ENGLAND JOURNAL OF MEDICINE

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

Impact of culture medium on the expansion of T cells for immunotherapy

(2009) Keisuke Sato et al.   CYTOTHERAPY

   T Cell Immune Manipulation during Chronic Phase of Simian HIV Infection Confers Immunological Benefits

(2009) Z. Ali et al.   JOURNAL OF IMMUNOLOGY

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

Toll-Like Receptor Expression and Function in Subsets of Human γδ T Lymphocytes

(2009) K. Pietschmann et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A Rapid Crosstalk of Human γδ T Cells and Monocytes Drives the Acute Inflammation in Bacterial Infections

(2009) Matthias Eberl et al.   PLoS Pathogens

Association between Vγ2Vδ2 T Cells and Disease Progression after Infection with Closely Related Strains of HIV in China

(2008) Haishan Li et al.   CLINICAL INFECTIOUS DISEASES

Characteristics of Circulating T Cell Receptor γδ T Cells from Individuals Chronically Infected with Hepatitis B Virus (HBV): An Association between Vδ2 Subtype and Chronic HBV Infection

(2008) Min Chen et al.   JOURNAL OF INFECTIOUS DISEASES

Optimal treatment for chronic active Epstein-Barr virus disease

(2008) Jeffrey I. Cohen   PEDIATRIC TRANSPLANTATION

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY