Interleukin-17 and its expanding biological functions

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

(2014) A. V. Rachitskaya et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

(2014) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

IL-17A Produced by    T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver

(2014) S. Hamada et al.   JOURNAL OF IMMUNOLOGY

IL-17 Signaling for mRNA Stabilization Does Not Require TNF Receptor-Associated Factor 6

(2014) J. Hartupee et al.   JOURNAL OF IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Endogenous IL-17 contributes to reduced tumor growth and metastasis

(2009) I. Kryczek et al.   BLOOD

IL-17F: Regulation, signaling and function in inflammation

(2009) Seon Hee Chang et al.   CYTOKINE

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Regulation and pro-inflammatory function of interleukin-17 family cytokines

(2009) Chen Dong   IMMUNOLOGICAL REVIEWS

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

(2009) Lin Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients

(2009) Jing-Ping Zhang et al.   JOURNAL OF HEPATOLOGY

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation

(2009) Emilio Fábrega et al.   LIVER TRANSPLANTATION

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

A pathogenic role of IL- 17 at the early stage of corneal allograft rejection

(2009) Haiyong Chen et al.   TRANSPLANT IMMUNOLOGY

Interleukin-17 as a drug target in human disease

(2009) Stefan Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

(2008) T. Yi et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

Transforming Growth Factor   Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

(2008) J.-S. Nam et al.   CANCER RESEARCH

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE

Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

(2008) Yongpeng Gu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

The Interleukin-17 Receptor Plays a Gender-Dependent Role in Host Protection against Porphyromonas gingivalis-Induced Periodontal Bone Loss

(2008) J. J. Yu et al.   INFECTION AND IMMUNITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8+T cells

(2008) Masaki Tajima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17

(2008) Muriel Pichavant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-Specific Interleukin-17-Producing CD4+ T Cells Are Detectable in Early Human Immunodeficiency Virus Type 1 Infection

(2008) F. Y. Yue et al.   JOURNAL OF VIROLOGY

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

(2008) Manuela Raffatellu et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE