Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder

The valproic acid-induced rodent model of autism

(2018) Chiara Nicolini et al.   EXPERIMENTAL NEUROLOGY

Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016

(2018) Guifeng Xu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Secular changes in the symptom level of clinically diagnosed autism

(2018) Olof Arvidsson et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

(2018) Nermin Eissa et al.   Frontiers in Neuroscience

Dopamine antagonists for treatment resistance in autism spectrum disorders: review and focus on BDNF stimulators loxapine and amitriptyline

(2017) Jessica A. Hellings et al.   EXPERT OPINION ON PHARMACOTHERAPY

Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [11 C]DASB PET study

(2017) Junhee Lee et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Prescription Trends of Psychotropics in Children and Adolescents with Autism Based on Nationwide Health Insurance Data

(2017) Minha Hong et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

(2017) Oliver D Howes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Infant acetylcholine, dopamine, and melatonin dysregulation: Neonatal biomarkers and causal factors for ASD and ADHD phenotypes

(2017) Kahl Hellmer et al.   MEDICAL HYPOTHESES

Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors

(2017) Yunjin Lee et al.   MOLECULAR NEUROBIOLOGY

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia

(2017) A Devor et al.   MOLECULAR PSYCHIATRY

Autism genetics: opportunities and challenges for clinical translation

(2017) Jacob A. S. Vorstman et al.   NATURE REVIEWS GENETICS

Prevalence of Autism Spectrum Disorders with and without Intellectual Disability by Gestational Age at Birth in the Stockholm Youth Cohort: a Register Linkage Study

(2017) Sherlly Xie et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden

(2017) Christopher Gillberg et al.   PEDIATRIC NEUROLOGY

Interventions Targeting Sensory Challenges in Autism Spectrum Disorder: A Systematic Review

(2017) Amy S. Weitlauf et al.   PEDIATRICS

Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review

(2017) Nila Sathe et al.   PEDIATRICS

Pharmacogenomics of autism spectrum disorder

(2017) Jacob T Brown et al.   PHARMACOGENOMICS

Autism risk following antidepressant medication during pregnancy

(2017) A. Viktorin et al.   PSYCHOLOGICAL MEDICINE

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

(2017) Yuta Hara et al.   PSYCHOPHARMACOLOGY

Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

(2017) Rui Chen et al.   Molecular Autism

Altered expression of histamine signaling genes in autism spectrum disorder

(2017) C Wright et al.   Translational Psychiatry

Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism

(2017) J Naaijen et al.   Translational Psychiatry

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

(2017) Alaa Alachkar et al.   Frontiers in Pharmacology

Low Retinal Dehydrogenase 1 (RALDH1) Level in Prepubertal Boys with Autism Spectrum Disorder: A Possible Link to Dopamine Dysfunction?

(2017) Denis Pavăl et al.   Clinical Psychopharmacology and Neuroscience

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

(2017) Nobuhiro Nakai et al.   Science Advances

Use of psychotropic drugs in patients with autism spectrum disorders: a systematic review

(2016) K. Jobski et al.   ACTA PSYCHIATRICA SCANDINAVICA

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

(2016) Bassem Sadek et al.   BEHAVIOURAL BRAIN RESEARCH

Treatment options for the management of pervasive developmental disorders

(2016) Kathryn Nash et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?

(2016) G. Stubbs et al.   MEDICAL HYPOTHESES

Angelman syndrome — insights into a rare neurogenetic disorder

(2016) Karin Buiting et al.   Nature Reviews Neurology

Diagnosis and treatment of obsessive compulsive behavior in a boy with Duchenne muscular dystrophy and autism spectrum disorder: A case report

(2016) Jos G.M. Hendriksen et al.   NEUROMUSCULAR DISORDERS

Cherry-picked ligands at histamine receptor subtypes

(2016) Bassem Sadek et al.   NEUROPHARMACOLOGY

Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links

(2016) S.W. Hulbert et al.   NEUROSCIENCE

The emerging roles of MicroRNAs in autism spectrum disorders

(2016) Julien Fregeac et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Using venlafaxine to treat behavioral disorders in patients with autism spectrum disorder

(2016) Giuliana Galli Carminati et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genetic and non-genetic animal models for autism spectrum disorders (ASD)

(2016) Zivanit Ergaz et al.   REPRODUCTIVE TOXICOLOGY

MiRNA-34 and stress response

(2016) Diego Andolina et al.   Oncotarget

Does Prenatal Valproate Interact with a Genetic Reduction in the Serotonin Transporter? A Rat Study on Anxiety and Cognition

(2016) Bart A. Ellenbroek et al.   Frontiers in Neuroscience

Analysis ofCHRNA7rare variants in autism spectrum disorder susceptibility

(2015) Elena Bacchelli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Detection of Circulating miRNA Levels in Schizophrenia

(2015) Hui Wei et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology

(2015) Jason A. Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Do Histamine receptor 3 antagonists have a place in the therapy for schizophrenia?

(2015) Bart Ellenbroek et al.   CURRENT PHARMACEUTICAL DESIGN

Loxapine Add-on for Adolescents and Adults with Autism Spectrum Disorders and Irritability

(2015) Jessica A. Hellings et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Autism Spectrum Disorders: Translating human deficits into mouse behavior

(2015) E. Pasciuto et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

(2015) Katharine Chisholm et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system

(2015) Li Wang et al.   PSYCHOPHARMACOLOGY

Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders

(2015) Janine M LaSalle et al.   Epigenomics

Erratum: Corrigendum: Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

(2015) Claire Piochon et al.   Nature Communications

Complex nature of apparently balanced chromosomal rearrangements in patients with autism spectrum disorder

(2015) Anne-Claude Tabet et al.   Molecular Autism

Effects of an H3R Antagonist on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

(2015) Diego Baronio et al.   PLoS One

Autism spectrum disorders and hyperactive/impulsive behaviors in Japanese patients with Prader-Willi syndrome: A comparison between maternal uniparental disomy and deletion cases

(2014) Hiroyuki Ogata et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Pre- and Perinatal Risk Factors for Autism Spectrum Disorder in a New Jersey Cohort

(2014) Lauren A. Maramara et al.   JOURNAL OF CHILD NEUROLOGY

Genotype to phenotype relationships in autism spectrum disorders

(2014) Jonathan Chang et al.   NATURE NEUROSCIENCE

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD)

(2014) Michael Nguyen et al.   NEUROCHEMISTRY INTERNATIONAL

Drug therapy in autism: a present and future perspective

(2014) Baldeep Kumar et al.   Pharmacological Reports

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

(2014) Kazuhiro Takuma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Histaminergic system in brain disorders: lessons from the translational approach and future perspectives

(2014) Diego Baronio et al.   Annals of General Psychiatry

SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking

(2014) E Bowton et al.   Translational Psychiatry

The Neglected Role of Histamine in Alzheimer’s Disease

(2013) Fatemeh Naddafi et al.   American Journal of Alzheimers Disease and Other Dementias

Ethotransmission: communication of emotional states through ultrasonic vocalization in rats

(2013) Stefan M Brudzynski   CURRENT OPINION IN NEUROBIOLOGY

Genetic variation in dopamine-related gene expression influences motor skill learning in mice

(2013) Y. Qian et al.   GENES BRAIN AND BEHAVIOR

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

(2013) P J Hamilton et al.   MOLECULAR PSYCHIATRY

Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism

(2013) Golan Karvat et al.   NEUROPSYCHOPHARMACOLOGY

MicroRNAs as biomarkers for CNS disease

(2013) Pooja Rao et al.   Frontiers in Molecular Neuroscience

Reversal of Oxidative Stress by Histamine H3 Receptor-Ligands in Experimental Models of Schizophrenia

(2012) D. Mahmood et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

(2012) Paula A. Garay et al.   BRAIN BEHAVIOR AND IMMUNITY

Preclinical research in Rett syndrome: setting the foundation for translational success

(2012) D. M. Katz et al.   Disease Models & Mechanisms

Female Mecp2+/− mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies

(2012) Rodney C. Samaco et al.   HUMAN MOLECULAR GENETICS

Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia

(2012) Jordan W. Brown et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Brain Activity Mapping in Mecp2 Mutant Mice Reveals Functional Deficits in Forebrain Circuits, Including Key Nodes in the Default Mode Network, that are Reversed with Ketamine Treatment

(2012) M. Kron et al.   JOURNAL OF NEUROSCIENCE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

(2012) Jennifer A Ronesi et al.   NATURE NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

GABA system dysfunction in autism and related disorders: From synapse to symptoms

(2012) Suzanne Coghlan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents

(2012) Guy Griebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Modeling an autism risk factor in mice leads to permanent immune dysregulation

(2012) E. Y. Hsiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

(2012) J. Veenstra-VanderWeele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

Pre-, peri- and neonatal risk factors for autism

(2011) VINCENT GUINCHAT et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders

(2011) Fady M. Mikhail et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1

(2011) Anne Gregor et al.   BMC Medical Genetics

Maternal infection and autism

(2011) Paul H. Patterson   BRAIN BEHAVIOR AND IMMUNITY

Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

(2011) Olga Peñagarikano et al.   CELL

Issues in the Management of Challenging Behaviours of Adults with Autism Spectrum Disorder

(2011) Johnny L. Matson et al.   CNS DRUGS

Reduced transcript expression of genes affected by inherited and de novo CNVs in autism

(2011) Alex S Nord et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Strain-dependent effects of the histamine H4 receptor antagonist JNJ7777120 in a murine model of acute skin inflammation

(2011) Gabriella Coruzzi et al.   EXPERIMENTAL DERMATOLOGY

Prefrontal nicotinic receptors control novel social interaction between mice

(2011) Maria Elena Avale et al.   FASEB JOURNAL

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

(2011) Shunsuke Kataoka et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

16p13.11 duplication is a risk factor for a wide spectrum of neuropsychiatric disorders

(2011) Arivudainambi Ramalingam et al.   JOURNAL OF HUMAN GENETICS

FXR1P But Not FMRP Regulates the Levels of Mammalian Brain-Specific microRNA-9 and microRNA-124

(2011) X.-L. Xu et al.   JOURNAL OF NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study

(2011) Ling Shan et al.   NEUROBIOLOGY OF AGING

Fish consumption and prenatal methylmercury exposure: Cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study

(2011) Philip W. Davidson et al.   NEUROTOXICOLOGY

Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-analysis

(2011) H. Gardener et al.   PEDIATRICS

Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia

(2011) Detelina Grozeva et al.   SCHIZOPHRENIA RESEARCH

Genetics of autism spectrum disorders

(2011) Daniel H. Geschwind   TRENDS IN COGNITIVE SCIENCES

miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor

(2010) Hailin Wang et al.   BRAIN RESEARCH

Histamine Pharmacology and New CNS Drug Targets

(2010) Ekaterini Tiligada et al.   CNS Neuroscience & Therapeutics

Fetal Valproate Syndrome: Clinical and Neuro-developmental Features in Two Sibling Pairs

(2010) Arnold L. Christianson et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

AUTISM IN THALIDOMIDE EMBRYOPATHY: A POPULATION STUDY

(2010) K. Strömland et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Pharmacotherapies for Neurodevelopmental Disorders

(2010) Daniel Z. Wetmore et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Behavioral and Cerebellar Transmission Deficits in Mice Lacking the Autism-Linked Gene Islet Brain-2

(2010) J. Giza et al.   JOURNAL OF NEUROSCIENCE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

(2010) A. A. Scott-Van Zeeland et al.   Science Translational Medicine

Once-monthly paliperidone injection for the treatment of schizophrenia

(2010) Delia Bishara   Neuropsychiatric Disease and Treatment

A method for rapid, targeted CNV genotyping identifies rare variants associated with neurocognitive disease

(2009) H. C. Mefford et al.   GENOME RESEARCH

A Placebo-Controlled, Fixed-Dose Study of Aripiprazole in Children and Adolescents With Irritability Associated With Autistic Disorder

(2009) Ronald N. Marcus et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Divalproex Sodium vs Placebo for the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorders

(2009) Eric Hollander et al.   NEUROPSYCHOPHARMACOLOGY

Aripiprazole in the Treatment of Irritability in Children and Adolescents With Autistic Disorder

(2009) R. Owen et al.   PEDIATRICS

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

(2009) Gin C. Hsieh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Genetic overlap between autism, schizophrenia and bipolar disorder

(2009) Liam S Carroll et al.   Genome Medicine

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

(2008) S Jill James et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Unraveling Autism

(2008) Dietrich A. Stephan   AMERICAN JOURNAL OF HUMAN GENETICS

A DRD1 haplotype is associated with risk for autism spectrum disorders in male‐only affected sib‐pair families

(2008) Joe A. Hettinger et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Criteria for validating mouse models of psychiatric diseases

(2008) Kathryn K. Chadman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

(2008) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics

(2008) Y. von Coburg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Use of clonidine in children with autism spectrum disorders

(2008) Xue Ming et al.   BRAIN & DEVELOPMENT

Activation of the maternal immune system alters cerebellar development in the offspring

(2008) Limin Shi et al.   BRAIN BEHAVIOR AND IMMUNITY

The histamine H3receptor: an attractive target for the treatment of cognitive disorders

(2008) T A Esbenshade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Copy-number variations associated with neuropsychiatric conditions

(2008) Edwin H. Cook Jr et al.   NATURE

The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13

(2008) Amber Hogart et al.   NEUROBIOLOGY OF DISEASE

Histamine in the Nervous System

(2008) Helmut L. Haas et al.   PHYSIOLOGICAL REVIEWS

Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid

(2008) Tomasz Schneider et al.   PSYCHONEUROENDOCRINOLOGY

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR

Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching

(2007) Martha F. McCool et al.   NEUROBIOLOGY OF LEARNING AND MEMORY