☆ 4.8 Letter

Rare SHANK2 variants in schizophrenia

MOLECULAR PSYCHIATRY (2015)

Journal

MOLECULAR PSYCHIATRY

Volume 20, Issue 12, Pages 1487-1488

Publisher

NATURE PUBLISHING GROUP

DOI: 10.1038/mp.2015.122

Keywords

-

Categories

Biochemistry & Molecular Biology Neurosciences Psychiatry

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Psychiatry

Rare germline variants in individuals diagnosed with schizophrenia within multiplex families

Shangzhong Li, Lynn E. DeLisi, Stefan McDonough

Summary: An extensive study analyzed whole genome sequences of 61 affected individuals from 15 families, revealing that most schizophrenia polygenic risk scores fell within the control range, while very rare damaging variants in certain candidate disease-related genes were found in six families, indicating their potential contributions to the heritability of schizophrenia.

PSYCHIATRY RESEARCH (2021)

Add to Collection

Article Genetics & Heredity

Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants

Margaret A. A. Hojlo, Merhawi Ghebrelul, Casie A. A. Genetti, Richard Smith, Shira Rockowitz, Emma Deaso, Alan H. H. Beggs, Pankaj B. B. Agrawal, David C. C. Glahn, Joseph Gonzalez-Heydrich, Catherine A. A. Brownstein

Summary: Children and adolescents with early-onset psychosis have more rare genetic variants, and this study found an increased burden of rare variants in the GRIN2A gene in individuals with early-onset psychosis compared to controls. GRIN2A variants have been associated with various neuropsychiatric disorders, highlighting its role in early-onset psychosis.

GENES (2023)

Add to Collection

Article Neurosciences

Identification of novel SHANK2 variants in two Chinese families via exome and RNA sequencing

Yong Wu, Wenzhou Li, Bo Tan, Sanchuan Luo

Summary: This study identified two novel loss of function variants in the SHANK2 gene, expanding the spectrum of SHANK2 variants. RNA sequencing and functional enrichment analysis provided insights into the molecular mechanisms underlying SHANK2-related disorders, revealing aberrant expression of genes involved in protein binding and synaptic functions.

FRONTIERS IN NEUROSCIENCE (2023)

Add to Collection

Article Clinical Neurology

Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort

David Baez-Nieto, Andrew Allen, Seth Akers-Campbell, Lingling Yang, Nikita Budnik, Amaury Pupo, Young-Cheul Shin, Giulio Genovese, Maofu Liao, Eduardo Perez-Palma, Henrike Heyne, Dennis Lal, Diane Lipscombe, Jen Q. Pan

Summary: This study characterized the functional effects of CACNA1I variants in a Swedish schizophrenia cohort and found that rare variants from schizophrenia patients mainly alter the activation of the Ca(V)3.3 channel by voltage, whereas variants from control subjects are typically associated with reduced Ca(V)3.3 protein expression.

BRAIN (2022)

Add to Collection

Article Genetics & Heredity

Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites

Lorenzo Bomba, Klaudia Walter, Qi Guo, Praveen Surendran, Kousik Kundu, Suraj Nongmaithem, Mohd Anisul Karim, Isobel D. Stewart, Claudia Langenberg, John Danesh, Emanuele Di Angelantonio, David J. Roberts, Willem H. Ouwehand, Ian Dunham, Adam S. Butterworth, Nicole Soranzo

Summary: Metabolite levels measured in the human population were analyzed to identify associations with rare genetic variants. The study identified 40 novel associations, of which 28 were replicated, between rare coding variants and metabolite levels. Algorithms were developed to prioritize driver variants and statistical analyses were used to test the directionality of associations between metabolite and protein levels. The study found that 66% of reported associations involved gene targets of approved drugs or bioactive drug-like compounds, validating efforts in drug target research.

AMERICAN JOURNAL OF HUMAN GENETICS (2022)

Add to Collection

Article Genetics & Heredity

Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families

Ambrin Fatima, Uzma Abdullah, Muhammad Farooq, Yuan Mang, Mana M. Mehrjouy, Maria Asif, Zafar Ali, Niels Tommerup, Shahid M. Baig

Summary: Rare, highly penetrant variants of genes involved in glutamatergic neurotransmission may contribute to the etiology of schizophrenia in two multiplex Pakistani families. Genetic investigations of multiplex families could be a powerful approach to identify rare genetic variants involved in complex disorders.

GENES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families

I-Hang Chung, Yu-Shu Huang, Ting-Hsuan Fang, Chia-Hsiang Chen

Summary: Schizophrenia and affective disorder are complex mental disorders with high heritability. Rare variants contribute to the genetic liability of these two disorders. Whole genome sequencing analysis identified multiple rare inherited variants in two families, providing evidence that these variants may contribute to the heritability of psychiatric disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

Naushaba Hasin, Lace M. Riggs, Tatyana Shekhtman, Justin Ashworth, Robert Lease, Rediet T. Oshone, Elizabeth M. Humphries, Judith A. Badner, Pippa A. Thomson, David C. Glahn, David W. Craig, Howard J. Edenberg, Elliot S. Gershon, Francis J. McMahon, John I. Nurnberger, Peter P. Zandi, John R. Kelsoe, Jared C. Roach, Todd D. Gould, Seth A. Ament

Summary: Bipolar disorder is a severe mental health condition characterized by alternating mood states. By analyzing genome sequences, this study identified variants in 741 genes that are associated with bipolar disorder. These genes are involved in synaptic and nuclear functions and overlap with risk genes for neurodevelopmental disorders.

MOLECULAR PSYCHIATRY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Elmo Christian Saarentaus, Aki Samuli Havulinna, Nina Mars, Ari Ahola-Olli, Tuomo Tapio Johannes Kiiskinen, Juulia Partanen, Sanni Ruotsalainen, Mitja Kurki, Lea Martta Urpa, Lei Chen, Markus Perola, Veikko Salomaa, Juha Veijola, Minna Mannikko, Ira M. Hall, Olli Pietilainen, Jaakko Kaprio, Samuli Ripatti, Mark Daly, Aarno Palotie

Summary: The study compared the impact of CNVs carriers and non-carriers on health, cognition, and socioeconomic factors, finding that high-risk CNVs carriers have lower educational attainment and household income. PRS for intelligence and schizophrenia affect these traits, while CNVs have a smaller impact.

MOLECULAR PSYCHIATRY (2021)

Add to Collection

Article Psychiatry

Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis

Martilias Farrell, Tyler E. Dietterich, Matthew K. Harner, Lisa M. Bruno, Dawn M. Filmyer, Rita A. Shaughnessy, Maya L. Lichtenstein, Allison M. Britt, Tamara F. Biondi, James J. Crowley, Gabriel Lazaro-Munoz, Annika E. Forsingdal, Jacob Nielsen, Michael Didriksen, Jonathan S. Berg, Jia Wen, Jin Szatkiewicz, Rose Mary Xavier, Patrick F. Sullivan, Richard C. Josiassen

Summary: This study investigates the relationship between copy number variants (CNVs) and treatment-resistant psychosis in patients with psychotic disorders. It suggests that CNVs, especially those associated with neurodevelopmental risk, may impact treatment resistance and serve as biological markers for studying this condition.

SCHIZOPHRENIA BULLETIN (2023)

Add to Collection

Article Neurosciences

Identification of VIPR2 rare and common variants in the Chinese Han population with schizophrenia

Jiajun Yin, Juan Zhou, Fang Fang, Shui Yu, Jun Wang, Jianmin Yuan, Zhenhe Zhou

Summary: This study sequenced the exons and un-translated portions of the VIPR2 gene in 1804 Chinese Han patients with schizophrenia and 996 healthy counterparts, identifying 19 rare non-synonymous mutations and 1 frameshift deletion associated with schizophrenia. Among them, 5 variants have never been reported before. The study provides further evidence for the role of the VIPR2 gene in susceptibility to schizophrenia.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)

Add to Collection

Editorial Material Multidisciplinary Sciences

Contribution of rare variants to traits

Luke M. M. Evans, Pamela N. Romero N. Villela

Summary: An analysis of rare genetic variants shows their impact on human traits is mediated through similar biological pathways as common variants, enhancing our understanding of their influence on complex traits.

NATURE (2023)

Add to Collection

Article Cell Biology

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang

Summary: The study identifies SHANK2 as a frequently amplified regulator of the Hippo pathway in human cancer, promoting cancer progression. Overexpression of SHANK2 in multiple human cell lines disrupts Hippo signaling, while depletion of SHANK2 restores Hippo signaling and halts cellular proliferation.

PROTEIN & CELL (2021)

Add to Collection

Article Multidisciplinary Sciences

Harnessing rare variants in neuropsychiatric and neurodevelopment disorders-a Keystone Symposia report

Jennifer Cable, Ryan H. Purcell, Elise Robinson, Jacob A. S. Vorstman, Wendy K. Chung, John N. Constantino, Stephan J. Sanders, Mustafa Sahin, Ricardo E. Dolmetsch, Bina Maniar Shah, Audrey Thurm, Christa L. Martin, Carrie E. Bearden, Jennifer G. Mulle

Summary: Research has shown that rare high-risk variants can help elucidate the biological mechanisms of more common idiopathic diseases, demonstrating genetic heterogeneity and variable expressivity. Experts highlighted the need for detailed natural history studies of rare disorders, challenges in cohort recruitment, and the importance of viewing phenotypes as quantitative traits impacted by rare variants.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Rare genetic variants impact muscle strength

Yunfeng Huang, Dora Bodnar, Chia-Yen Chen, Gabriela Sanchez-Andrade, Mark Sanderson, Jun E. Shi, Katherine S. Meilleur, Matthew A. Hurles, Sebastian Gerety, Ellen Tsai, Heiko Runz

Summary: The authors conducted an exome study on hand grip strength, which serves as a proxy for overall muscle strength. They discovered six significant genes, associated with diseases, and found that rare and common genetic variants both contribute to muscle strength. Muscle strength has a strong genetic basis and is a predictor of various negative health outcomes, including mortality.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Biochemical Research Methods

IFN-γ secretion of PBMC from non-drug-allergic control persons: Considerations for the validity of a positive lymphocyte transformation test

Andreas Glaessner, Gerda Wurpts, Stefanie Roeseler, Amir S. Yazdi, Christine Kraemer, Amol Fatangare, Albert Sickmann, Per Hoffmann, Markus Noethen, Bernhardt Sachs

Summary: The lymphocyte transformation test (LTT) is used to detect drug sensitization in allergic patients. However, the specificity of LTT has not been analyzed in relation to specific drugs in a larger control group. This study investigated the impact of amoxicillin, cefuroxime, and clindamycin on the specificity of LTT with ELISA read-out in control persons.

JOURNAL OF IMMUNOLOGICAL METHODS (2023)

Add to Collection

Article Genetics & Heredity

Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders

Wenqianglong Li, Hang Zhou, Johan H. Thygesen, Mathis Heydtmann, Iain Smith, Franziska Degenhardt, Markus Noethen, Marsha Y. Morgan, Henry R. Kranzler, Joel Gelernter, Nicholas Bass, Andrew McQuillin

Summary: This study identifies a chromosome 15 variant that is associated with the diagnostic criteria of ASPD and explores the pleiotropic associations of ASPD with other disorders and traits. It suggests that SLCO3A1 may be a genetic risk factor for ASPD and provides insight into the genetic architecture of ASPD.

PSYCHIATRIC GENETICS (2023)

Add to Collection

Article Multidisciplinary Sciences

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Reedik Maegi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-Soler, Ayoung Jeong, Katherine A. Fawcett, Hansjorg Baurecht, Elke Rodriguez, Alexessander Couto Alves, Ashish Kumar, Patrick M. Sleiman, Xiao Chang, Carolina Medina-Gomez, Chen Hu, Cheng-jian Xu, Cancan Qi, Sarah El-Heis, Philip Titcombe, Elie Antoun, Joao Fadista, Carol A. Wang, Elisabeth Thiering, Baojun Wu, Sara Kress, Dilini M. Kothalawala, Latha Kadalayil, Jiasong Duan, Hongmei Zhang, Sabelo Hadebe, Thomas Hoffmann, Eric Jorgenson, Helene Choquet, Neil Risch, Pal Njolstad, Ole A. Andreassen, Stefan Johansson, Catarina Almqvist, Tong Gong, Vilhelmina Ullemar, Robert Karlsson, Patrik K. E. Magnusson, Agnieszka Szwajda, Esteban G. Burchard, Jacob P. Thyssen, Torben Hansen, Line L. Karhus, Thomas M. Dantoft, Alexander C. S. N. Jeanrenaud, Ahla Ghauri, Andreas Arnold, Georg Homuth, Susanne Lau, Markus M. Noethen, Norbert Huebner, Medea Imboden, Alessia Visconti, Mario Falchi, Veronique Bataille, Pirro Hysi, Natalia Ballardini, Dorret I. Boomsma, Jouke J. Hottenga, Martina Mueller-Nurasyid, Tarunveer S. Ahluwalia, Jakob Stokholm, Bo Chawes, Ann-Marie M. Schoos, Ana Esplugues, Mariona Bustamante, Benjamin Raby, Syed Arshad, Chris German, Tonu Esko, Lili A. Milani, Andres Metspalu, Chikashi Terao, Katrina Abuabara, Mari Loset, Kristian Hveem, Bo Jacobsson, Maria Pino-Yanes, David P. Strachan, Niels Grarup, Allan Linneberg, Young-Ae Lee, Nicole Probst-Hensch, Stephan Weidinger, Marjo-Riitta Jarvelin, Erik Melen, Hakon Hakonarson, Alan D. Irvine, Deborah Jarvis, Tamar Nijsten, Liesbeth Duijts, Judith M. Vonk, Gerard H. Koppelmann, Keith M. Godfrey, Sheila J. Barton, Bjarke Feenstra, Craig E. Pennell, Peter D. Sly, Patrick G. Holt, L. Keoki Williams, Hans Bisgaard, Klaus Bonnelykke, John Curtin, Angela Simpson, Clare Murray, Tamara Schikowski, Supinda Bunyavanich, Scott T. Weiss, John W. Holloway, Josine L. Min, Sara J. Brown, Marie Standl, Lavinia Paternoster

Summary: This study conducted the largest genome-wide association study (GWAS) on atopic dermatitis (AD) to date, identifying 81 replicated AD-associated loci in Europeans and 10 additional loci in a multi-ancestry analysis. The implicated genes are predominantly involved in immune pathways relevant to atopic inflammation and may offer drug repurposing opportunities.

NATURE COMMUNICATIONS (2023)

Add to Collection

Review Psychiatry

Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review

Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye

Summary: This article introduces a research strategy that leverages innovative tools and techniques such as data federation, geospatial observation, and data integration to understand the impact of environmental factors on the brain and mental illness. The presented example demonstrates the potential of this research to identify brain mechanisms underlying mental health symptoms related to environmental adversity and develop targeted interventions. The development of objective biomarkers and evidence-based interventions can greatly improve outcomes of environment-related mental illness.

JAMA PSYCHIATRY (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Whole genome sequencing of a German cohort to understand host genetics in COVID-19

Axel Schmidt, Eva C. Schulte, Susanne Motameny, Nicolas Casadei, Fabian Brand, Michael Nothnagel, Elaheh Vojgani, German Demidov, Kerstin Becker, Janine Altmueller, Andre Heimbach, Markus M. Noethen, Peter Nuernberg, Stephan Ossowski, Olaf Riess, Kerstin Ludwig

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Link of disorders in the schizo-affective spectrum and comorbidity with neurobiological correlates

Lisa Sindermann, Udo Dannlowski, Susanne Meinert, Elisabeth Johanna Leehr, Lena Waltemate, Hannah Lemke, Alexandrea Winter, Katharina Thiel, Katharina Brosch, Tina Meller, Frederike Stein, Per Hoffmann, Axel Krug, Tilo Kircher, Till Andlauer, Eva Beins, Markus M. Noethen, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Investigation of polygenic scores in patients with social anxiety disorder

Angelina Vogelsang, Man Long Chung, Lisa Sindermann, Friederike David, Christina Elling, Laura-Effi Seib-Pfeifer, Stefanie Heilmann-Heimbach, Per Hoffmann, Stefan Herms, Boerge Schmidt, Katharina Domschke, Vanessa Nieratschker, Udo Dannlowski, Elisabeth Johanna Leehr, Eric Leibing, Markus M. Noethen, Franziska Geiser, Johannes Schumacher, Carlo Maj, Rupert Conrad, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Methylome-wide association studies of major depressive disorder, bipolar disorder and schizophrenia spectrum disorders in the German FOR2107 cohort

Friederike David, Fabian Streit, Josef Frank, Lea Sirignano, Lea Zillich, Stefan Herms, Per Hoffmann, Till Andlauer, Tilo Kircher, Udo Dannlowski, Stephanie Witt, Marcella Rietschel, Markus M. Noethen, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Investigation of the association between loci with opposite directional effects across multiple neuropsychiatric disorders and human brain structure

Lydia M. Federmann, Lisa Sindermann, Christiane Jockwitz, Friederike David, Alexander Teumer, Dominique I. Hilger, Markus M. Noethen, Katrin Amunts, Udo Dannlowski, Thomas Muehleisen, Svenja Caspers, Sven Cichon, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

The role of rare variants in male-pattern hair loss: Analysis of whole-exome sequencing data in the UK Biobank

Sabrina Henne, Sugirthan Sivalingam, Lara Hochfeld, Carlo Maj, Oleg Borisov, Andreas Buness, Markus M. Noethen, Peter Krawitz, Stefanie Heilmann-Heimbach

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Genetic characterization of patients with bipolar disorder and controls for the generation of induced pluripotent stem cells

Karola Huenten, Friederike David, Sugirthan Sivalingam, Bettina Burger, Eva Beins, Lea Sirignano, Fabian Streit, Frederike Stein, Tamara Krutenko, Petra Ina Pfefferle, Stefan Herms, Per Hoffmann, Marcella Rietschel, Michael Peitz, Sven Cichon, Oliver Bruestle, Markus M. Noethen, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Pharmacogenetic association of diabetes associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMGCoA-reductase inhibitors - results of the Heinz Nixdorf Recall Study

Dominik Jung, Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Amir A. Mahabdi, Per Hoffmann, Raimund Erbel, Markus M. Noethen, Hagen Sjard Bachmann

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Colorectal cancer risk: the interplay of polygenic background, high-impact monogenic variants, and family history

Carlo Maj, Emadeldin Hassanin, Hannah Klinkhammer, Friederike David, Dheeraj Bobbili, Rana Aldisi, Nuria Duenas, Claudia Perne, Markus M. Noethen, Robert Huneburg, Peter Krawitz, Joan Brunet, Gabriel Capella, Patrick May, Andreas Forstner, Andreas Mayr, Isabel Spier, Stefan Aretz

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Generation and characterisation of induced pluripotent stem cell-derived microglia to study the influence of genetic risk for depression on microglial functions

Eva Beins, Ronja Hollstein, Kerstin Ludwig, Per Hoffmann, Markus M. Noethen, Andreas Forstner

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

Add to Collection

Review Psychiatry

Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience

Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye

Summary: Climate change, pollution, urbanization, socioeconomic inequality, and the COVID-19 pandemic have affected brain health. Research using innovative data integration tools can identify brain mechanisms underlying environment-related mental illness and inform innovative treatments. This research will lead to the development of objective biomarkers and evidence-based interventions to improve outcomes of environment-related mental illness.

JAMA PSYCHIATRY (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.