Molecular Signatures of HIV-1 Envelope Associated with HIV-Associated Neurocognitive Disorders

How and why do T cells and their derived cytokines affect the injured and healthy brain?

(2017) Anthony J. Filiano et al.   NATURE REVIEWS NEUROSCIENCE

Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations

(2017) Michelli F. Oliveira et al.   PLoS Pathogens

Biomarkers of chemotaxis and inflammation in cerebrospinal fluid and serum in individuals with HIV-1 subtype C versus B

(2016) Sergio M. de Almeida et al.   JOURNAL OF NEUROVIROLOGY

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

The HAND Database: a gateway to understanding the role of HIV in HIV-associated neurocognitive disorders

(2015) Tess Z Griffin et al.   BMC Medical Genomics

Phenotypic Correlates of HIV-1 Macrophage Tropism

(2015) Kathryn T. Arrildt et al.   JOURNAL OF VIROLOGY

Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

(2015) Megan E. Mefford et al.   VIROLOGY

Discordant patterns of tissue-specific genetic characteristics in the HIV-1 env gene from HIV-associated neurocognitive disorder (HAND) and non-HAND patients

(2014) Yabo Ouyang et al.   JOURNAL OF NEUROVIROLOGY

Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope

(2014) Teresa H Evering et al.   Retrovirology

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy

(2013) Christian Eggers et al.   JOURNAL OF NEUROVIROLOGY

Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities

(2013) S. B. Joseph et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

(2012) Hamid Salimi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Machine Learning Approach for Identifying Amino Acid Signatures in the HIV Env Gene Predictive of Dementia

(2012) Alexander G. Holman et al.   PLoS One

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

(2012) Paul J Peters et al.   Retrovirology

Characterization of HIV Type 1 env Gene in Cerebrospinal Fluid and Blood of Infected Chinese Patients

(2011) Feili Wei et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Up-regulation of the Neuronal Nicotinic Receptor α7 by HIV Glycoprotein 120

(2011) Leomar Y. Ballester et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intercompartmental Recombination of HIV-1 Contributes to env Intrahost Diversity and Modulates Viral Tropism and Sensitivity to Entry Inhibitors

(2011) R. J. P. Brown et al.   JOURNAL OF VIROLOGY

Selected amino acid mutations in HIV-1 B subtype gp41 are Associated with Specific gp120V3 signatures in the regulation of Co-Receptor usage

(2011) Salvatore Dimonte et al.   Retrovirology

HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

(2011) Gretja Schnell et al.   PLoS Pathogens

HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites

(2011) Alexander G Holman et al.   AIDS Research and Therapy

HIV-associated neurocognitive disorders: is there a hidden epidemic?

(2010) Justin C McArthur et al.   AIDS

Excess Mortality in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy: Temporal Changes and Risk Factors

(2010) Milo A. Puhan et al.   CLINICAL INFECTIOUS DISEASES

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

(2010) Lachlan R. Gray et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

A Conserved Determinant in the V1 Loop of HIV-1 Modulates the V3 Loop To Prime Low CD4 Use and Macrophage Infection

(2010) T. Musich et al.   JOURNAL OF VIROLOGY

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

(2010) Jasminka Sterjovski et al.   VIROLOGY

Cross-sectional characterization of HIV-1 env compartmentalization in cerebrospinal fluid over the full disease course

(2009) Patrick R Harrington et al.   AIDS

Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection

(2009) G. Schnell et al.   JOURNAL OF VIROLOGY

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

(2009) L. Gray et al.   JOURNAL OF VIROLOGY

Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 Envelopes

(2009) M. J. Duenas-Decamp et al.   JOURNAL OF VIROLOGY

Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12

(2009) Rebecca L Dunfee et al.   Retrovirology

Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1–Associated Dementia

(2009) Gretja Schnell et al.   PLoS Pathogens

Human Immunodeficiency Virus Type 1 Population Genetics and Adaptation in Newly Infected Individuals

(2008) M. Kearney et al.   JOURNAL OF VIROLOGY

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

(2008) Fiorella Rossi et al.   Retrovirology

HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

(2007) Marcus Kaul   Frontiers in Bioscience-Landmark