Scarless wound healing: Transitioning from fetal research to regenerative healing

Next generation human skin constructs as advanced tools for drug development

(2017) HE Abaci et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Interleukin-10–mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling

(2017) Swathi Balaji et al.   FASEB JOURNAL

Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas

(2016) Chenxi Yan et al.   AMERICAN JOURNAL OF PATHOLOGY

Lumican alleviates hypertrophic scarring by suppressing integrin-FAK signaling

(2016) Yuqian Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Scarless wound healing: finding the right cells and signals

(2016) Tripp Leavitt et al.   CELL AND TISSUE RESEARCH

Integrin-mediated regulation of epidermal wound functions

(2016) C. Michael DiPersio et al.   CELL AND TISSUE RESEARCH

Using human epithelial amnion cells in human de-epidermized dermis for skin regeneration

(2016) Lei-Wei Jiang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Generation of induced pluripotent stem cell line from foreskin fibroblasts

(2016) Aniela Skrzypczyk et al.   Stem Cell Research

Hyaluronic acid dressing (Healoderm) in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study

(2016) Moses Lee et al.   WOUND REPAIR AND REGENERATION

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

(2016) Michael K. Lichtman et al.   WOUND REPAIR AND REGENERATION

Healthy human second-trimester fetal skin is deficient in leukocytes and associated homing chemokines

(2016) Mariëlle Walraven et al.   WOUND REPAIR AND REGENERATION

Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy

(2016) Dylan E. Lee et al.   Stem Cell Research & Therapy

The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring

(2015) Judith E. Glim et al.   ARCHIVES OF ORAL BIOLOGY

An updated review of mechanotransduction in skin disorders: transcriptional regulators, ion channels, and microRNAs

(2015) Jing Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling

(2015) Jon M. Carthy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Scarless Wound Healing

(2015) Graham G. Walmsley et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Adalimumab treatment leads to reduction of tissue tumor necrosis factor-alpha correlated with venous leg ulcer improvement: a pilot study

(2015) Joshua D Fox et al.   International Wound Journal

Wnt signaling induces epithelial differentiation during cutaneous wound healing

(2015) Khosrow S Houschyar et al.   Organogenesis

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Extracellular matrix components of oral mucosa differ from skin and resemble that of foetal skin

(2014) Judith E. Glim et al.   ARCHIVES OF ORAL BIOLOGY

Hyaluronan: Biosynthesis and signaling

(2014) Davide Vigetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Integrin-mediated adhesion and mechano-sensing in cutaneous wound healing

(2014) Fiona N. Kenny et al.   CELL AND TISSUE RESEARCH

Photodynamic therapy inhibits the formation of hypertrophic scars in rabbit ears by regulating metalloproteinases and tissue inhibitor of metalloproteinase-1

(2014) Q. Wang et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

FOXO1, TGF-β Regulation and Wound Healing

(2014) Alhassan Hameedaldeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

(2014) H. Takada et al.   JOURNAL OF CELL SCIENCE

Cell Therapy for Wound Healing

(2014) Hi-Jin You et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction

(2014) Hye Sook Min et al.   LABORATORY INVESTIGATION

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

A Randomized Controlled Trial of the embrace Advanced Scar Therapy Device to Reduce Incisional Scar Formation

(2014) Michael T. Longaker et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Effects of interleukin-10 on cutaneous wounds and scars in humans of African continental ancestral origin

(2014) Ingrid Kieran et al.   WOUND REPAIR AND REGENERATION

Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model

(2014) Michael Januszyk et al.   Organogenesis

Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling

(2014) Anna I Arno et al.   Stem Cell Research & Therapy

BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

(2014) Xiao-Jing Zhu et al.   PLoS Genetics

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats

(2013) Kosuke Kaji et al.   JOURNAL OF GASTROENTEROLOGY

Kynurenine Increases Matrix Metalloproteinase-1 and -3 Expression in Cultured Dermal Fibroblasts and Improves Scarring In Vivo

(2013) Yunyuan Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biological effects of cellular stretch on human dermal fibroblasts

(2013) Chenyu Huang et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Wound Healing: A Paradigm for Regeneration

(2013) Victor W. Wong et al.   MAYO CLINIC PROCEEDINGS

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

The embrace Device Significantly Decreases Scarring following Scar Revision Surgery in a Randomized Controlled Trial

(2013) Angeline F. Lim et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Tissue Engineered Skin Substitutes Created by Laser-Assisted Bioprinting Form Skin-Like Structures in the Dorsal Skin Fold Chamber in Mice

(2013) Stefanie Michael et al.   PLoS One

Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

(2013) Jemima L. Whyte et al.   PLoS One

Design and Fabrication of Human Skin by Three-Dimensional Bioprinting

(2013) Vivian Lee et al.   TISSUE ENGINEERING PART C-METHODS

Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine

(2013) Chenyu Huang et al.   TRENDS IN MOLECULAR MEDICINE

Interleukin-10 reduces scar formation in both animal and human cutaneous wounds: Results of two preclinical and phase II randomized control studies

(2013) Ingrid Kieran et al.   WOUND REPAIR AND REGENERATION

A Mechanomodulatory Device to Minimize Incisional Scar Formation

(2013) Victor W. Wong et al.   Advances in Wound Care

Stem cells in embryonic skin development

(2012) Maria F Forni et al.   BIOLOGICAL RESEARCH

RNAi functionalized collagen-chitosan/silicone membrane bilayer dermal equivalent for full-thickness skin regeneration with inhibited scarring

(2012) Xing Liu et al.   BIOMATERIALS

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Tissue-engineered fetal dermal matrices

(2012) Tara Pouyani et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Direct comparison of the potency of human mesenchymal stem cells derived from amnion tissue, bone marrow and adipose tissue at inducing dermal fibroblast responses to cutaneous wounds

(2012) XIAOYU LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Epithelial stem cells and implications for wound repair

(2012) Maksim V. Plikus et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Soft tissue mechanotransduction in wound healing and fibrosis

(2012) Victor W. Wong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery

(2011) Gregg L. Semenza   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Microdeformation of Three-Dimensional Cultured Fibroblasts Induces Gene Expression and Morphological Changes

(2011) Feng Lu et al.   ANNALS OF PLASTIC SURGERY

Mesenchymal Stem Cells

(2011) Dah-Ching Ding et al.   CELL TRANSPLANTATION

Diminished Type III Collagen Promotes Myofibroblast Differentiation and Increases Scar Deposition in Cutaneous Wound Healing

(2011) Susan W. Volk et al.   CELLS TISSUES ORGANS

Pushing Back: Wound Mechanotransduction in Repair and Regeneration

(2011) Victor W. Wong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Review of the Role of Mechanical Forces in Cutaneous Wound Healing

(2011) Riaz Agha et al.   JOURNAL OF SURGICAL RESEARCH

Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression

(2011) Barbara Gawronska-Kozak   MATRIX BIOLOGY

Avotermin for Scar Improvement following Scar Revision Surgery: A Randomized, Double-Blind, Within-Patient, Placebo-Controlled, Phase II Clinical Trial

(2011) Karen So et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Characterization and quantification of wound-induced hair follicle neogenesis using in vivo confocal scanning laser microscopy

(2011) Chengxiang Fan et al.   SKIN RESEARCH AND TECHNOLOGY

Altered angiogenic balance in keloids: a key to therapeutic intervention

(2011) Nirupa Shyam Mogili et al.   Translational Research

Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring

(2011) Nick L. Occleston et al.   WOUND REPAIR AND REGENERATION

Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans

(2011) Willem M. van der Veer et al.   WOUND REPAIR AND REGENERATION

Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing

(2011) Gillian S. Ashcroft et al.   WOUND REPAIR AND REGENERATION

Bevacizumab: A potential agent for prevention and treatment of hypertrophic scar

(2010) Jian-Sheng Diao et al.   BURNS

Localization of tumour necrosis factor-alpha (TNF-α) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor

(2010) M. KRISTENSEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition

(2010) Kenichi Tamama et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo

(2010) Ekaterina Vorotnikova et al.   MATRIX BIOLOGY

Scarless Fetal Wound Healing: A Basic Science Review

(2010) Barrett J. Larson et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Tissue scaffolds for skin wound healing and dermal reconstruction

(2010) S. P. Zhong et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Electrospun hyaluronate–collagen nanofibrous matrix and the effects of varying the concentration of hyaluronate on the characteristics of foreskin fibroblast cells

(2009) Fu-Yin Hsu et al.   Acta Biomaterialia

Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing

(2009) Alan A. Thomay et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix metalloproteinase-2 and -9 activities in human keloids, hypertrophic and atrophic scars: a pilot study

(2009) S. Tanriverdi-Akhisaroglu et al.   CELL BIOCHEMISTRY AND FUNCTION

Management of Difficult Pediatric Facial Burns

(2009) Brent Egeland et al.   JOURNAL OF CRANIOFACIAL SURGERY

Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study

(2009) B. Zavan et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Cross-linked Collagen–Chondroitin Sulfate–Hyaluronic Acid Imitating Extracellular Matrix as Scaffold for Dermal Tissue Engineering

(2009) Weihong Wang et al.   TISSUE ENGINEERING PART C-METHODS

Wound healing in oral mucosa results in reduced scar formation as compared with skin: Evidence from the red Duroc pig model and humans

(2009) Joyce W. Wong et al.   WOUND REPAIR AND REGENERATION

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Post-burn axillary contractures in pediatric patients: A retrospective survey of management and outcome

(2008) Malachy E. Asuku et al.   BURNS

IL-10 Overexpression Decreases Inflammatory Mediators and Promotes Regenerative Healing in an Adult Model of Scar Formation

(2008) William H. Peranteau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The hidden cost of skin scars: quality of life after skin scarring

(2008) B.C. Brown et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Regulation of scar formation by vascular endothelial growth factor

(2008) Traci A Wilgus et al.   LABORATORY INVESTIGATION

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation

(2008) Ashley Gordon et al.   WOUND REPAIR AND REGENERATION