Inhibition of p16INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways
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Title
Inhibition of p16INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways
Authors
Keywords
p16<sup>INK4A</sup>, Human cardiac stem/progenitor cells, Heart failure, Myocardial infarction, cell rejuvenation, Lentiviral knockdown
Journal
Stem Cell Reviews and Reports
Volume 14, Issue 4, Pages 612-625
Publisher
Springer Nature
Online
2018-04-20
DOI
10.1007/s12015-018-9815-z
References
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Note: Only part of the references are listed.- Molecular mechanism of doxorubicin-induced cardiomyopathy – An update
- (2018) Kaviyarasi Renu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2018) Xiangrui Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer
- (2017) Daniela D’Arcangelo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2
- (2017) Larissa A. C. Carvalho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decline in cellular function of aged mouse c-kit+ cardiac progenitor cells
- (2017) Alessandra Castaldi et al. JOURNAL OF PHYSIOLOGY-LONDON
- Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2
- (2017) Alakananda Basu et al. PLoS One
- Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NFκB/iNOS Signal Pathway and Nitric Oxide Production
- (2017) Shuning Zhang et al. Scientific Reports
- Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis
- (2016) C. Li et al. HERZ
- Preconditioning c-Kit-positive Human Cardiac Stem Cells with a Nitric Oxide Donor Enhances Cell Survival through Activation of Survival Signaling Pathways
- (2016) Lei Teng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression
- (2016) Panagiotis Mistriotis et al. STEM CELLS
- Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
- (2016) Eric Aeby et al. Cell Reports
- Microsolvation and hydration enthalpies of CaS2O3(H2O) n (n = 0–19) and S2O3 2−(H2O) n (n = 0–16): an ab initio study
- (2015) Victor M. Rosas-García et al. JOURNAL OF MOLECULAR MODELING
- DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway
- (2015) YU-FENG YAN et al. Molecular Medicine Reports
- Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450
- (2015) C Cerella et al. Cell Death & Disease
- Resident c-kit+ cells in the heart are not cardiac stem cells
- (2015) Nishat Sultana et al. Nature Communications
- Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
- (2014) Mina Sasaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression
- (2014) Burcu Bayoglu et al. Journal of Atherosclerosis and Thrombosis
- c-kit+ cells minimally contribute cardiomyocytes to the heart
- (2014) Jop H. van Berlo et al. NATURE
- Heme Oxygenase-1 Induction Improves Cardiac Function following Myocardial Ischemia by Reducing Oxidative Stress
- (2014) Yossi Issan et al. PLoS One
- Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase
- (2013) Sadia Mohsin et al. CIRCULATION RESEARCH
- Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
- (2013) R. L. Thomas et al. GENES & DEVELOPMENT
- Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration
- (2013) S. Singh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
- (2013) J. Cadet et al. Cold Spring Harbor Perspectives in Biology
- Glutathione peroxidases
- (2012) Regina Brigelius-Flohé et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Telomeres and Mitochondria in the Aging Heart
- (2012) Javid Moslehi et al. CIRCULATION RESEARCH
- The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells against Apoptosis through Activation of the Extracellular Signal-regulated Kinase (ERK)/NRF2 Signaling Pathway and Cytokine Release
- (2012) Chuanxi Cai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
- (2012) Raj R Makkar et al. LANCET
- Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential
- (2012) Juhee Han et al. STEM CELLS
- Oxidative Stress and Antioxidant Defense
- (2012) Esra Birben et al. World Allergy Organization Journal
- Effects of Age and Heart Failure on Human Cardiac Stem Cell Function
- (2011) Daniela Cesselli et al. AMERICAN JOURNAL OF PATHOLOGY
- Novel cross-talk within the IKK family controls innate immunity
- (2011) Kristopher Clark et al. BIOCHEMICAL JOURNAL
- All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27
- (2011) Sun-Hye Park et al. CANCER LETTERS
- Peroxiredoxin 1 and its role in cell signaling
- (2011) Carola A. Neumann et al. CELL CYCLE
- Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
- (2011) L. Lapasset et al. GENES & DEVELOPMENT
- Cellular senescence and tumor suppressor gene p16
- (2011) Hani Rayess et al. INTERNATIONAL JOURNAL OF CANCER
- Sulfiredoxin Protein Is Critical for Redox Balance and Survival of Cells Exposed to Low Steady-state Levels of H2O2
- (2011) Jin Young Baek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Knockdown of Cyclin-dependent Kinase Inhibitors Induces Cardiomyocyte Re-entry in the Cell Cycle
- (2011) Valeria Di Stefano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
- (2011) Roberto Bolli et al. LANCET
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Mechanisms of Cell Protection by Heme Oxygenase-1
- (2010) Raffaella Gozzelino et al. Annual Review of Pharmacology and Toxicology
- Crosstalk of reactive oxygen species and NF-κB signaling
- (2010) Michael J Morgan et al. CELL RESEARCH
- The effects of nitric oxide-oxidase and putative glutathione-peroxidase activities of ceruloplasmin on the viability of cardiomyocytes exposed to hydrogen peroxide
- (2010) Mylène Paradis et al. FREE RADICAL BIOLOGY AND MEDICINE
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
- (2010) Maria Mirotsou et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation
- (2010) Yoshihiro Tsuchiya et al. MOLECULAR CELL
- Calcineurin Activates Cytoglobin Transcription in Hypoxic Myocytes
- (2009) Sarvjeet Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Telomere length measurement by a novel monochrome multiplex quantitative PCR method
- (2009) R. M. Cawthon NUCLEIC ACIDS RESEARCH
- Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors
- (2008) Heather J. Evans-Anderson et al. CIRCULATION RESEARCH
- IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB
- (2008) Johannes A. Schmid et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Risk factors for myocardial infarction in women and men: insights from the INTERHEART study
- (2008) Sonia S. Anand et al. EUROPEAN HEART JOURNAL
- Stem-cell therapy for cardiac disease
- (2008) Vincent F. M. Segers et al. NATURE
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