The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction

SynCAMs – From axon guidance to neurodevelopmental disorders

(2017) Jeannine A. Frei et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

(2017) Vladimir Sytnyk et al.   TRENDS IN NEUROSCIENCES

Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity

(2017) Gabby Rudenko   NEURAL PLASTICITY

An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count

(2016) Gang Chen et al.   ADDICTION BIOLOGY

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

(2016) Jana Drgonova et al.   MOLECULAR MEDICINE

Acute Morphine, Chronic Morphine, and Morphine Withdrawal Differently Affect Pleiotrophin, Midkine, and Receptor Protein Tyrosine Phosphatase β/ζ Regulation in the Ventral Tegmental Area

(2016) Daniel García-Pérez et al.   MOLECULAR NEUROBIOLOGY

Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks

(2016) Richard Sherva et al.   JAMA Psychiatry

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

(2016) S Stringer et al.   Translational Psychiatry

Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes

(2015) Xiaoming Zhong et al.   Annals of the New York Academy of Sciences

Unknown

(2015) Jana Drgonova et al.   MOLECULAR MEDICINE

Functional neuroimaging of amphetamine-induced striatal neurotoxicity in the pleiotrophin knockout mouse model

(2015) María Luisa Soto-Montenegro et al.   NEUROSCIENCE LETTERS

Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preference

(2015) Esther Gramage et al.   NEUROSCIENCE LETTERS

Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models

(2015) Jana Drgonova et al.   PLoS One

RPTPs in axons, synapses and neurology

(2015) Andrew W. Stoker   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

(2014) Wei Xu et al.   BMC Medical Genetics

SynCAMs extend their functions beyond the synapse

(2014) Jeannine A. Frei et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity

(2014) S. Fernandes et al.   MOLECULAR NEUROBIOLOGY

Genome-Wide Association Study of Copy Number Variations (CNVs) with Opioid Dependence

(2014) Dawei Li et al.   NEUROPSYCHOPHARMACOLOGY

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence

(2014) L. C. Bidwell et al.   PSYCHOPHARMACOLOGY

The CSMD1 genome-wide associated schizophrenia risk variant rs10503253 affects general cognitive ability and executive function in healthy males

(2014) Erasmia Koiliari et al.   SCHIZOPHRENIA RESEARCH

Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens

(2014) Jian Feng et al.   GENOME BIOLOGY

Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders

(2014) Holly N Cukier et al.   Molecular Autism

Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum

(2013) Esther Gramage et al.   BEHAVIOURAL BRAIN RESEARCH

Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases

(2013) Nicholas G. Selner et al.   BIOCHEMISTRY

TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis

(2013) Xian-yong Yin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A Matter of Balance: Role of Neurexin and Neuroligin at the Synapse

(2013) Marie Louise Bang et al.   NEUROCHEMICAL RESEARCH

Cell Adhesion Molecules: Druggable Targets for Modulating the Connectome and Brain Disorders?

(2013) George R Uhl et al.   NEUROPSYCHOPHARMACOLOGY

Implications of genome wide association studies for addiction: Are our a priori assumptions all wrong?

(2013) F. Scott Hall et al.   PHARMACOLOGY & THERAPEUTICS

Curious cases: Altered dose–response relationships in addiction genetics

(2013) George R. Uhl et al.   PHARMACOLOGY & THERAPEUTICS

Soluble ICAM-5, a Product of Activity Dependent Proteolysis, Increases mEPSC Frequency and Dendritic Expression of GluA1

(2013) Irina Lonskaya et al.   PLoS One

Neuropsychological Deficits in Mice Depleted of the Schizophrenia Susceptibility Gene CSMD1

(2013) Vidar M. Steen et al.   PLoS One

Distinct Effects of Alcohol Consumption and Smoking on Genetic Alterations in Head and Neck Carcinoma

(2013) Mitsuyoshi Urashima et al.   PLoS One

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases

(2013) Y. S. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomic analysis of the striatum from pleiotrophin knockout and midkine knockout mice treated with cocaine reveals regulation of oxidative stress-related proteins potentially underlying cocaine-induced neurotoxicity and neurodegeneration

(2013) Marta Vicente-Rodríguez et al.   TOXICOLOGY

NrCAM-regulating neural systems and addiction-related behaviors

(2012) Hiroki Ishiguro et al.   ADDICTION BIOLOGY

Mouse models for studying genetic influences on factors determining smoking cessation success in humans

(2012) F. Scott Hall et al.   Annals of the New York Academy of Sciences

Association of Neurexin 3 polymorphisms with smoking behavior

(2012) E. Docampo et al.   GENES BRAIN AND BEHAVIOR

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development

(2012) Brent L. Fogel et al.   HUMAN MOLECULAR GENETICS

Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances

(2012) G R Uhl et al.   MOLECULAR PSYCHIATRY

Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior

(2012) Jacqueline M Barker et al.   NATURE NEUROSCIENCE

The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior

(2012) Joanna I Giza et al.   NEUROPSYCHOPHARMACOLOGY

Cadherins in Brain Morphogenesis and Wiring

(2012) Shinji Hirano et al.   PHYSIOLOGICAL REVIEWS

Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative Associations, Including Cadherin 13 (CDH13)

(2012) Amy B. Hart et al.   PLoS One

Assessment of Behaviors Modeling Aspects of Schizophrenia in Csmd1 Mutant Mice

(2012) Margaret G. Distler et al.   PLoS One

Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder

(2012) Byung Kuk Yoo et al.   Psychiatry Investigation

Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems

(2012) Keizo Hirano et al.   Frontiers in Molecular Neuroscience

Periadolescent amphetamine treatment causes transient cognitive disruptions and long-term changes in hippocampal LTP depending on the endogenous expression of pleiotrophin

(2011) Esther Gramage et al.   ADDICTION BIOLOGY

The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia

(2011) Bjarte Håvik et al.   BIOLOGICAL PSYCHIATRY

Developmental Expression Mapping of a Gene Implicated in Multiple Neurodevelopmental Disorders, A2bp1 (Fox1)

(2011) Elizabeth A.D. Hammock et al.   DEVELOPMENTAL NEUROSCIENCE

Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms

(2011) Scott F. Stoltenberg et al.   DRUG AND ALCOHOL DEPENDENCE

The role of NrCAM in neural development and disorders—Beyond a simple glue in the brain

(2011) Takeshi Sakurai   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

(2011) Lauren T Gehman et al.   NATURE GENETICS

Genomic Regions Identified by Overlapping Clusters of Nominally-Positive SNPs from Genome-Wide Studies of Alcohol and Illegal Substance Dependence

(2011) Catherine Johnson et al.   PLoS One

Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes

(2010) Geoff Joslyn et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

“Replicated” genome wide association for dependence on illegal substances: Genomic regions identified by overlapping clusters of nominally positive SNPs

(2010) Tomas Drgon et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 Influence Different Pathways Leading to Smoking Behavior from Adolescence to Mid-Adulthood

(2010) Francesca Ducci et al.   BIOLOGICAL PSYCHIATRY

Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: Family and case control study

(2010) Agnieszka Samochowiec et al.   BRAIN RESEARCH

Increase in polysialyltransferase gene expression following LTP in adult rat dentate gyrus

(2010) G. Guiraudie-Capraz et al.   HIPPOCAMPUS

Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats

(2010) Junran Cao et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5

(2010) Katherine Conant et al.   JOURNAL OF NEUROCHEMISTRY

Unknown

(2010) George Uhl et al.   MOLECULAR MEDICINE

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Neurexins Physically and Functionally Interact with GABAA Receptors

(2010) Chen Zhang et al.   NEURON

Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement

(2010) George R Uhl et al.   PHARMACOGENOMICS

Genome Wide Association for Addiction: Replicated Results and Comparisons of Two Analytic Approaches

(2010) Tomas Drgon et al.   PLoS One

Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain

(2010) S. P. Galuska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction

(2010) John W. Wright et al.   NEURAL PLASTICITY

Molecular Genetics of Addiction and Related Heritable Phenotypes

(2009) George R. Uhl et al.   Annals of the New York Academy of Sciences

Genome-wide Association Study of Alcohol Dependence

(2009) Jens Treutlein et al.   ARCHIVES OF GENERAL PSYCHIATRY

An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons

(2009) J.-A. Lee et al.   GENES & DEVELOPMENT

Unknown

(2009) Tomas Drgon et al.   MOLECULAR MEDICINE

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study

(2009) Gabriela Novak et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Are there genetic influences on addiction: evidence from family, adoption and twin studies

(2008) Arpana Agrawal et al.   ADDICTION

Association ofPTPRBgene polymorphism with drug addiction

(2008) Hiroki Ishiguro et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Molecular Genetics of Successful Smoking Cessation

(2008) George R. Uhl et al.   ARCHIVES OF GENERAL PSYCHIATRY

Genome-Wide Association for Methamphetamine Dependence

(2008) George R. Uhl et al.   ARCHIVES OF GENERAL PSYCHIATRY

Endogenous Modulators for Drug Dependence

(2008) Kiyofumi Yamada   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples

(2008) Catherine Johnson et al.   BMC Medical Genetics

Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus

(2008) Marzena Maćkowiak et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pleiotrophin prevents cocaine-induced toxicity in vitro

(2008) Esther Gramage et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

(2008) C. Zhang et al.   GENES & DEVELOPMENT

Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity

(2008) L. D. Matzel et al.   GENES BRAIN AND BEHAVIOR

ICAM-5—A novel two-facetted adhesion molecule in the mammalian brain

(2008) Carl G. Gahmberg et al.   IMMUNOLOGY LETTERS

Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction

(2008) Sabah Kelai et al.   NEUROREPORT

Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning

(2008) M. Maćkowiak et al.   NEUROSCIENCE

Neurobiological mechanisms for opponent motivational processes in addiction

(2008) G. F Koob et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts

(2008) M. Heine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Higher order” addiction molecular genetics: Convergent data from genome-wide association in humans and mice

(2007) George R. Uhl et al.   BIOCHEMICAL PHARMACOLOGY