Acute Morphine, Chronic Morphine, and Morphine Withdrawal Differently Affect Pleiotrophin, Midkine, and Receptor Protein Tyrosine Phosphatase β/ζ Regulation in the Ventral Tegmental Area

Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preference

(2015) Esther Gramage et al.   NEUROSCIENCE LETTERS

Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration

(2014) Daniel García-Pérez et al.   JOURNAL OF NEUROIMMUNOLOGY

CCL5 and cytokine expression in the rat brain: Differential modulation by chronic morphine and morphine withdrawal

(2013) Lee A. Campbell et al.   BRAIN BEHAVIOR AND IMMUNITY

Distribution of different isoforms of receptor protein tyrosine phosphatase γ (Ptprg-RPTP γ) in adult mouse brain: upregulation during neuroinflammation

(2013) Erika Lorenzetto et al.   Brain Structure & Function

Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives

(2013) G Herradón et al.   BRITISH JOURNAL OF PHARMACOLOGY

Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum

(2013) Alessandro Ciccarelli et al.   NEUROPHARMACOLOGY

Genetic inactivation of pleiotrophin but not midkine potentiates clonidine-induced alpha-2 adrenergic-mediated analgesia

(2013) Marta Vicente-Rodríguez et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function

(2012) D García-Pérez et al.   BRITISH JOURNAL OF PHARMACOLOGY

The heparin binding growth factors midkine and pleiotrophin regulate the antinociceptive effects of morphine through α2-adrenergic independent mechanisms

(2012) Esther Gramage et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety

(2011) Darin J. Knapp et al.   BRAIN BEHAVIOR AND IMMUNITY

Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson’s disease

(2011) Rui D. S. Prediger et al.   JOURNAL OF NEURAL TRANSMISSION

Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats

(2011) Irene RE Taravini et al.   Molecular Neurodegeneration

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

(2011) Michelle S. Mazei-Robison et al.   NEURON

Midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: functional differences between pleiotrophin and midkine

(2011) E. Gramage et al.   NEUROSCIENCE

The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice

(2010) Esther Gramage et al.   ADDICTION BIOLOGY

Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus

(2010) Yun B Kim et al.   BMC NEUROSCIENCE

Genetic inactivation of Pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum

(2010) E. Gramage et al.   NEUROSCIENCE

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

(2010) Scott J. Russo et al.   TRENDS IN NEUROSCIENCES

Naloxone-precipitated withdrawal enhances ERK phosphorylation in prefrontal association cortex and accumbens nucleus of morphine-dependent mice

(2009) Tao Li et al.   NEUROSCIENCE LETTERS

Impact of Alcohol Abuse on Protein Expression of Midkine and Excitatory Amino Acid Transporter 1 in the Human Prefrontal Cortex

(2008) Traute Flatscher-Bader et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Pleiotrophin receptor RPTP-ζ/β expression is up-regulated by l-DOPA in striatal medium spiny neurons of parkinsonian rats

(2008) Juan Esteban Ferrario et al.   JOURNAL OF NEUROCHEMISTRY

Neurotrophic factors and structural plasticity in addiction

(2008) Scott J. Russo et al.   NEUROPHARMACOLOGY