Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches

WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases

(2017) Shazad Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases

(2017) Helio S. Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria

(2017) David M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

White Paper: Developing Antimicrobial Drugs for Resistant Pathogens, Narrow-Spectrum Indications, and Unmet Needs

(2017) Helen W Boucher et al.   JOURNAL OF INFECTIOUS DISEASES

A QM/MM study on the enzymatic inactivation of cefotaxime

(2017) Ignacio Lizana et al.   JOURNAL OF MOLECULAR MODELING

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

(2017) Karina Calvopiña et al.   MOLECULAR MICROBIOLOGY

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

(2017) Christopher T. Lohans et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase

(2017) Josephine P. Werner et al.   PROTEIN SCIENCE

Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors

(2017) Emilia Caselli et al.   ACS Infectious Diseases

Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C β-Lactamase

(2017) Alexandra A. Bouza et al.   ACS Infectious Diseases

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514

(2017) Adam B. Shapiro et al.   ACS Infectious Diseases

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

(2017) Thomas F. Durand-Réville et al.   Nature Microbiology

Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins

(2016) Andrew M. King et al.   ACS Chemical Biology

Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030

(2016) Nhu Q. Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Insight into the Mechanism of Hydrolysis of Meropenem by OXA-23 Serine-β-lactamase Gained by Quantum Mechanics/Molecular Mechanics Calculations

(2016) Jacopo Sgrignani et al.   BIOCHEMISTRY

Structure-Function Relationships of Class D Carbapenemases

(2016) Jean-Denis Docquier et al.   CURRENT DRUG TARGETS

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam

(2016) David Yuxin Wang et al.   Future Medicinal Chemistry

New β-Lactamase Inhibitors in the Clinic

(2016) Krisztina M. Papp-Wallace et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

In vitro and in vivo activities of the diazabicyclooctane OP0595 against AmpC-derepressed Pseudomonas aeruginosa

(2016) Akihiro Morinaka et al.   JOURNAL OF ANTIBIOTICS

Deacylation Mechanism and Kinetics of Acyl–Enzyme Complex of Class C β-Lactamase and Cephalothin

(2016) Ravi Tripathi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

(2016) Jürgen Brem et al.   Nature Communications

Engineering Specificity from Broad to Narrow: Design of a β-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β-Lactamase

(2016) Dar-Chone Chow et al.   ACS Infectious Diseases

Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

(2015) Amabel Lapuebla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 β-Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone

(2015) Tao Che et al.   BIOCHEMISTRY

Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases

(2015) David M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’

(2015) Akihiro Morinaka et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

(2015) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel chimeric peptide with antimicrobial activity

(2015) Begum Alaybeyoglu et al.   JOURNAL OF PEPTIDE SCIENCE

Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition

(2015) Dustin T. King et al.   ACS Infectious Diseases

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

(2015) Nikhil P. Krishnan et al.   PLoS One

Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48

(2014) Sushmita D. Lahiri et al.   ACS Chemical Biology

Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance

(2014) S. D. Lahiri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of TEM-1 by Avibactam (NXL-104): Insights from Quantum Mechanics/Molecular Mechanics Metadynamics Simulations

(2014) Jacopo Sgrignani et al.   BIOCHEMISTRY

Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii

(2014) Rachel A. Powers et al.   BIOCHEMISTRY

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

(2014) Timothy A. Blizzard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragment-based inhibitor discovery against β-lactamase

(2014) Derek A Nichols et al.   Future Medicinal Chemistry

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

(2014) Donatella Tondi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition

(2014) Elizabeth A. Rodkey et al.   PLoS One

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

(2013) Nicholas G. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases

(2013) Sushmita D. Lahiri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa

(2013) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

(2013) David E. Ehmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ABCD’s of β-lactamase nomenclature

(2013) Karen Bush   JOURNAL OF INFECTION AND CHEMOTHERAPY

β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme

(2013) Elizabeth A. Rodkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resistance to antibiotics targeted to the bacterial cell wall

(2013) I. Nikolaidis et al.   PROTEIN SCIENCE

Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

(2012) Wei Ke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosis

(2012) Hua Xu et al.   BIOCHEMISTRY

The Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variants

(2012) Wei Ke et al.   ChemMedChem

Carboxylation and Decarboxylation of Active Site Lys 84 Controls the Activity of OXA-24 β-Lactamase of Acinetobacter baumannii: Raman Crystallographic and Solution Evidence

(2012) Tao Che et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamase

(2012) Elizabeth A. Rodkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

(2012) Wei Ke et al.   PLoS One

Fragment-guided design of subnanomolar  -lactamase inhibitors active in vivo

(2012) O. Eidam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avibactam is a covalent, reversible, non- -lactam  -lactamase inhibitor

(2012) D. E. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase

(2011) Jared M. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone

(2011) Krisztina M. Papp-Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors

(2011) Ken Coleman   CURRENT OPINION IN MICROBIOLOGY

Theoretical Investigation on Reaction of Sulbactam with Wild-Type SHV-1 β-Lactamase: Acylation, Tautomerization, and Deacylation

(2011) Rui Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors

(2010) Donatella Tondi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors ofAcinetobacter baumanniiOXA-24 Carbapenemase

(2010) German Bou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three Decades of the Class A β-Lactamase Acyl-Enzyme

(2009) Jed Fisher et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Strategic Design of an Effective β-Lactamase Inhibitor

(2008) Priyaranjan Pattanaik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases

(2007) Aranapakam M. Venkatesan et al.   BIOORGANIC & MEDICINAL CHEMISTRY