The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam
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Title
The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam
Authors
Keywords
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Journal
Future Medicinal Chemistry
Volume 8, Issue 10, Pages 1063-1084
Publisher
Future Science, LTD
Online
2016-06-23
DOI
10.4155/fmc-2016-0078
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Note: Only part of the references are listed.- Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins
- (2016) Andrew M. King et al. ACS Chemical Biology
- In VitroandIn VivoActivities of OP0595, a New Diazabicyclooctane, against CTX-M-15-Positive Escherichia coli and KPC-Positive Klebsiella pneumoniae
- (2016) Akihiro Morinaka et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design
- (2016) Laura J. Rojas et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition
- (2016) Hwanho Choi et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants
- (2015) David M. Livermore et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Restricting the ψ Torsion Angle Has Stereoelectronic Consequences on a Scissile Bond: An Electronic Structure Analysis
- (2015) Eric R. Strieter et al. BIOCHEMISTRY
- The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles’ Heel of Methicillin-Resistant Staphylococcus aureus
- (2015) Ivan Acebron et al. CURRENT MEDICINAL CHEMISTRY
- Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases
- (2015) Krisztina M. Papp-Wallace et al. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases
- (2015) David M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’
- (2015) Akihiro Morinaka et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The Tipper–Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA)
- (2015) Jennifer Fishovitz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- “Mind the Gap”: Raman Evidence for Rapid Inactivation of CTX-M-9 β-Lactamase Using Mechanism-Based Inhibitors that Bridge the Active Site
- (2015) Hossein Heidari-Torkabadi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study
- (2015) Nikhil P. Krishnan et al. PLoS One
- Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48
- (2014) Sushmita D. Lahiri et al. ACS Chemical Biology
- Inactivation of TEM-1 by Avibactam (NXL-104): Insights from Quantum Mechanics/Molecular Mechanics Metadynamics Simulations
- (2014) Jacopo Sgrignani et al. BIOCHEMISTRY
- Tebipenem, a New Carbapenem Antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis
- (2014) Saugata Hazra et al. BIOCHEMISTRY
- Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®
- (2014) Timothy A. Blizzard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Penicillin-binding protein 2a of methicillin-resistantStaphylococcus aureus
- (2014) Jennifer Fishovitz et al. IUBMB LIFE
- Siderophore Receptor-Mediated Uptake of Lactivicin Analogues in Gram-Negative Bacteria
- (2014) Jeremy Starr et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antibiotic use in eastern Europe: a cross-national database study in coordination with the WHO Regional Office for Europe
- (2014) Ann Versporten et al. LANCET INFECTIOUS DISEASES
- A variety of roles for versatile zinc in metallo-β-lactamases
- (2014) A. I. Karsisiotis et al. Metallomics
- Alkylidene Oxapenem β-Lactamase Inhibitors Revisited: Potent Broad Spectrum Activity but New Stability Challenges
- (2014) Matthew D. Miller et al. ACS Medicinal Chemistry Letters
- Enantioselective Synthesis and Profiling of Two Novel Diazabicyclooctanone β-Lactamase Inhibitors
- (2014) Hui Xiong et al. ACS Medicinal Chemistry Letters
- In VitroActivities of Ceftazidime-Avibactam and Aztreonam-Avibactam against 372 Gram-Negative Bacilli Collected in 2011 and 2012 from 11 Teaching Hospitals in China
- (2013) Xiaojuan Wang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases
- (2013) Sushmita D. Lahiri et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Ceftazidime-Avibactam: a Novel Cephalosporin/β-lactamase Inhibitor Combination
- (2013) George G. Zhanel et al. DRUGS
- β-Lactamase inhibitors: a review of the patent literature (2010 – 2013)
- (2013) John D Buynak EXPERT OPINION ON THERAPEUTIC PATENTS
- Targeting metallo-β-lactamase enzymes in antibiotic resistance
- (2013) Dustin T King et al. Future Medicinal Chemistry
- Antibiotics in the clinical pipeline in 2013
- (2013) Mark S Butler et al. JOURNAL OF ANTIBIOTICS
- Activity of biapenem (RPX2003) combined with the boronate -lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae
- (2013) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial
- (2013) Christopher Lucasti et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases
- (2013) David E. Ehmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Practical and Cost-Effective Manufacturing Route for the Synthesis of a β-Lactamase Inhibitor
- (2013) Steven P. Miller et al. ORGANIC LETTERS
- Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226
- (2012) Wei Ke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- In VitroActivity of MK-7655, a Novel β-Lactamase Inhibitor, in Combination with Imipenem against Carbapenem-Resistant Gram-Negative Bacteria
- (2012) Elizabeth B. Hirsch et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variants
- (2012) Wei Ke et al. ChemMedChem
- Efficacy and safety of ceftazidime–avibactam versus imipenem–cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study
- (2012) José A. Vazquez et al. CURRENT MEDICAL RESEARCH AND OPINION
- Improving known classes of antibiotics: an optimistic approach for the future
- (2012) Karen Bush CURRENT OPINION IN PHARMACOLOGY
- Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase
- (2012) Marisa L. Winkler et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition
- (2012) Dustin T. King et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Development of New Drugs for an Old Target — The Penicillin Binding Proteins
- (2012) Astrid Zervosen et al. MOLECULES
- Prolonged Infusions of β-Lactam Antibiotics: Implication for Antimicrobial Stewardship
- (2012) Jomy M. George et al. PHARMACOTHERAPY
- Fragment-guided design of subnanomolar -lactamase inhibitors active in vivo
- (2012) O. Eidam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Avibactam is a covalent, reversible, non- -lactam -lactamase inhibitor
- (2012) D. E. Ehmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors
- (2011) Yi Xia et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
- (2011) Ken Coleman CURRENT OPINION IN MICROBIOLOGY
- A Computational Evaluation of the Mechanism of Penicillin-Binding Protein-Catalyzed Cross-Linking of the Bacterial Cell Wall
- (2011) Qicun Shi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin-Binding Protein
- (2011) Astrid Zervosen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Metallo-β-lactamases: a last frontier for β-lactams?
- (2011) Giuseppe Cornaglia et al. LANCET INFECTIOUS DISEASES
- A Concise Synthesis of a β-Lactamase Inhibitor
- (2011) Ian K. Mangion et al. ORGANIC LETTERS
- Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-ProducingEnterobacteriaceae
- (2010) David M. Livermore et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Insights into the Mode of Inhibition of Class A SHV-1 β-Lactamases Revealed by Boronic Acid Transition State Inhibitors
- (2010) Wei Ke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non- -Lactam -Lactamase Inhibitor
- (2010) T. Stachyra et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors
- (2010) Donatella Tondi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: First boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity
- (2010) Qiang Tan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Three Decades of -Lactamase Inhibitors
- (2010) S. M. Drawz et al. CLINICAL MICROBIOLOGY REVIEWS
- Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
- (2010) Karen Bush CURRENT OPINION IN MICROBIOLOGY
- Current Challenges in Antimicrobial Chemotherapy
- (2010) Carine Bebrone et al. DRUGS
- New β-lactam antibiotics and β-lactamase inhibitors
- (2010) Karen Bush et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Activity of chequerboard combinations of ceftaroline and NXL104 versus -lactamase-producing Enterobacteriaceae
- (2010) S. Mushtaq et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structural Basis for the Interaction of Lactivicins with Serine β-Lactamases
- (2010) Tom Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis
- (2010) José A Caminero et al. LANCET INFECTIOUS DISEASES
- Updated Functional Classification of -Lactamases
- (2009) K. Bush et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural and Biochemical Characterization of the Interaction between KPC-2 β-Lactamase and β-Lactamase Inhibitor Protein,
- (2009) Melinda S. Hanes et al. BIOCHEMISTRY
- Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents
- (2009) Devdutt Chaturvedi et al. CHEMICAL SOCIETY REVIEWS
- Why Clinically Used Tazobactam and Sulbactam Are Poor Inhibitors of OXA-10 β-Lactamase: Raman Crystallographic Evidence†
- (2008) Monica A. Totir et al. BIOCHEMISTRY
- Structure of the Covalent Adduct Formed between Mycobacterium tuberculosis β-Lactamase and Clavulanate†‡
- (2008) Lee W. Tremblay et al. BIOCHEMISTRY
- The Mechanisms of Catalysis by Metallo -Lactamases
- (2008) Michael I. Page et al. BIOINORGANIC CHEMISTRY AND APPLICATIONS
- NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum -lactamases and carbapenemases
- (2008) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structure of PBP-A from Thermosynechococcus elongatus, a Penicillin-Binding Protein Closely Related to Class A β-Lactamases
- (2008) Carole Urbach et al. JOURNAL OF MOLECULAR BIOLOGY
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