Molecular Determinants of the Promiscuity of MexB and MexY Multidrug Transporters of Pseudomonas aeruginosa
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Title
Molecular Determinants of the Promiscuity of MexB and MexY Multidrug Transporters of Pseudomonas aeruginosa
Authors
Keywords
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Journal
Frontiers in Microbiology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-06-01
DOI
10.3389/fmicb.2018.01144
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Note: Only part of the references are listed.- Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump
- (2018) Attilio Vittorio Vargiu et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB
- (2018) Yasuhiro Matsunaga et al. eLife
- Computational modelling of efflux pumps and their inhibitors
- (2017) Venkata Krishnan Ramaswamy et al. Essays in Biochemistry
- An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
- (2017) Zhao Wang et al. eLife
- Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters
- (2017) Venkata Krishnan Ramaswamy et al. Scientific Reports
- Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB
- (2016) Sabine Schuster et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays
- (2016) Alfred D. Kinana et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Insights into the Inhibitory Mechanism of D13-9001 to the Multidrug Transporter AcrB through Molecular Dynamics Simulations
- (2016) Zhicheng Zuo et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
- (2016) Hanno Sjuts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB
- (2015) Ramkumar Iyer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
- (2015) Xian-Zhi Li et al. CLINICAL MICROBIOLOGY REVIEWS
- Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
- (2015) Chad W. Hopkins et al. Journal of Chemical Theory and Computation
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds
- (2015) Giuliano Malloci et al. MOLECULES
- The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins
- (2015) Dima Kozakov et al. Nature Protocols
- AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
- (2015) Jessica M. A. Blair et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB
- (2015) Zhicheng Zuo et al. Scientific Reports
- Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter
- (2015) Robert Schulz et al. Biomed Research International
- Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites
- (2015) Lorraine Marsh Biomed Research International
- Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies
- (2015) Martyn F. Symmons et al. Frontiers in Microbiology
- Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa
- (2015) Jürg Dreier et al. Frontiers in Microbiology
- Recent advances toward a molecular mechanism of efflux pump inhibition
- (2015) Timothy J. Opperman et al. Frontiers in Microbiology
- Structural basis of RND-type multidrug exporters
- (2015) Akihito Yamaguchi et al. Frontiers in Microbiology
- Bacterial Multidrug Efflux Transporters
- (2014) Jared A. Delmar et al. Annual Review of Biophysics
- Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors
- (2014) Attilio V. Vargiu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
- (2014) Jingjing Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance
- (2014) Jessica MA Blair et al. Future Microbiology
- β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket
- (2014) Naoki Kobayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid14: The Amber Lipid Force Field
- (2014) Callum J. Dickson et al. Journal of Chemical Theory and Computation
- MLP Tools: a PyMOL plugin for using the molecular lipophilicity potential in computer-aided drug design
- (2014) Nils Oberhauser et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- UniProt: a hub for protein information
- (2014) NUCLEIC ACIDS RESEARCH
- MexY-Promoted Aminoglycoside Resistance in Pseudomonas aeruginosa: Involvement of a Putative Proximal Binding Pocket in Aminoglycoside Recognition
- (2014) C. H.-F. Lau et al. mBio
- rDock: A Fast, Versatile and Open Source Program for Docking Ligands to Proteins and Nucleic Acids
- (2014) Sergio Ruiz-Carmona et al. PLoS Computational Biology
- Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
- (2014) Thomas Eicher et al. eLife
- RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms
- (2013) Paolo Ruggerone et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments
- (2013) Xin-Qiu Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural basis for the inhibition of bacterial multidrug exporters
- (2013) Ryosuke Nakashima et al. NATURE
- Determinants of Intrinsic Aminoglycoside Resistance in Pseudomonas aeruginosa
- (2012) Thomas Krahn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Porter domain opening and closing motions in the multi-drug efflux transporter AcrB
- (2012) Nadine Fischer et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance
- (2012) L. Fernandez et al. CLINICAL MICROBIOLOGY REVIEWS
- Recognition of Imipenem and Meropenem by the RND-Transporter MexB Studied by Computer Simulations
- (2012) Francesca Collu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
- (2012) A. V. Vargiu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
- (2012) T. Eicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Essential dynamics: foundation and applications
- (2012) Isabella Daidone et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Functionality Mapping on Internal Surfaces of Multidrug Transporter AcrB Based on Molecular Theory of Solvation: Implications for Drug Efflux Pathway
- (2011) Takashi Imai et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Role of Water during the Extrusion of Substrates by the Efflux Transporter AcrB
- (2011) Robert Schulz et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations
- (2011) Attilio V. Vargiu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
- (2011) F. Sievers et al. Molecular Systems Biology
- Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
- (2011) Ryosuke Nakashima et al. NATURE
- OPM database and PPM web server: resources for positioning of proteins in membranes
- (2011) Mikhail A. Lomize et al. NUCLEIC ACIDS RESEARCH
- Pseudomonas Aeruginosa: Resistance to the Max
- (2011) Keith Poole Frontiers in Microbiology
- Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations
- (2010) Robert Schulz et al. PLoS Computational Biology
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Drug transport mechanism of the AcrB efflux pump
- (2009) Klaas M. Pos BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms
- (2009) P. D. Lister et al. CLINICAL MICROBIOLOGY REVIEWS
- Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa
- (2009) Gaby Sennhauser et al. JOURNAL OF MOLECULAR BIOLOGY
- Antibiotics for Emerging Pathogens
- (2009) M. A. Fischbach et al. SCIENCE
- Site-Directed Mutagenesis Reveals Amino Acid Residues in the Escherichia coli RND Efflux Pump AcrB That Confer Macrolide Resistance
- (2008) C. Wehmeier et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mechanisms of RND multidrug efflux pumps
- (2008) Hiroshi Nikaido et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
- (2008) J. A. Bohnert et al. JOURNAL OF BACTERIOLOGY
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
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