SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

Microbial nutrient niches in the gut

(2017) Fátima C. Pereira et al.   ENVIRONMENTAL MICROBIOLOGY

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

(2017) Saumel Ahmadi et al.   npj Genomic Medicine

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

(2016) V Coothankandaswamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

(2016) Jennifer Foulke-Abel et al.   GASTROENTEROLOGY

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins

(2016) Amanda M. Pattison et al.   INFECTION AND IMMUNITY

Relationships among CFTR expression, HCO3−secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies

(2016) Viral S. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

(2015) Ellappan Babu et al.   BIOCHEMICAL JOURNAL

Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation

(2015) Jeremy A. Scott et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Cystic fibrosis mouse model-dependent intestinal structure and gut microbiome

(2015) Mark Bazett et al.   MAMMALIAN GENOME

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

(2015) Harriet Corvol et al.   Nature Communications

Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3 - transport and reduces survival in CFTR-deficient mice

(2014) Xuemei Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation

(2014) Stan Pasyk et al.   PROTEOMICS

Sildenafil Acts as Potentiator and Corrector of CFTR but Might be not Suitable for the Treatment of CF Lung Disease

(2013) Geraldine Leier et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The effect of NO-donors on chloride efflux, intracellular Ca2+ concentration and mRNA expression of CFTR and ENaC in cystic fibrosis airway epithelial cells

(2013) Igor Oliynyk et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities

(2013) Weili Li et al.   HUMAN GENETICS

Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretionin vivo

(2013) Anurag Kumar Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

(2013) Gary Rudnick et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Cystic Fibrosis Intestine

(2013) R. C. De Lisle et al.   Cold Spring Harbor Perspectives in Medicine

Ileal smooth muscle dysfunction and remodeling in cystic fibrosis

(2012) P.-A. Risse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nitric Oxide and L-Arginine Deficiency in Cystic Fibrosis

(2012) Hartmut Grasemann et al.   CURRENT PHARMACEUTICAL DESIGN

Intestinal Smooth Muscle Dysfunction Develops Postnatally in Cystic Fibrosis Mice

(2012) Robert C. De Lisle et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

(2012) Lei Sun et al.   NATURE GENETICS

L-arginine Supplementation Improves Responses to Injury and Inflammation in Dextran Sulfate Sodium Colitis

(2012) Lori A. Coburn et al.   PLoS One

Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis

(2011) Hartmut Grasemann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

(2011) Senthil Karunakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse models of cystic fibrosis: Phenotypic analysis and research applications

(2011) Martina Wilke et al.   Journal of Cystic Fibrosis

Evidence of Intestinal Inflammation in Patients With Cystic Fibrosis

(2010) Steven L Werlin et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth

(2010) M. P. Rogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice

(2009) Emily M. Bradford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

(2008) Senthil Karunakaran et al.   BIOCHEMICAL JOURNAL

Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine

(2008) Nancy M. Walker et al.   GASTROENTEROLOGY

Human solute carrier SLC6A14 is the β-alanine carrier

(2008) Catriona M. H. Anderson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS