Synthetic single domain antibodies for the conformational trapping of membrane proteins

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Exploring conformational equilibria of a heterodimeric ABC transporter

(2017) M Hadi Timachi et al.   eLife

Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs

(2016) Pawel K. Dominik et al.   STRUCTURE

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels

(2016) Carlo Bertozzi et al.   PLOS BIOLOGY

NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

(2016) Sandrine Moutel et al.   eLife

A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter

(2015) Magdalena A. Bukowska et al.   BIOCHEMISTRY

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Equilibrative Nucleoside Transporters 1 and 4

(2015) Cui Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Analysis of Bacterial ABC Transporter Inhibition by an Antibody Fragment

(2015) Shivani Ahuja et al.   STRUCTURE

Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications

(2014) Junrong Yan et al.   Journal of Translational Medicine

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

(2014) Ines A Ehrnstorfer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

(2014) M. Hohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proof of dual-topology architecture of Fluc F− channels with monobody blockers

(2014) Randy B. Stockbridge et al.   Nature Communications

In vitro nanobody discovery for integral membrane protein targets

(2014) Rupak Doshi et al.   Scientific Reports

From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display

(2013) Johannes Schilling et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Cell Adhesion by a Cadherin-11 Antibody Thwarts Bone Metastasis

(2013) Y.-C. Lee et al.   MOLECULAR CANCER RESEARCH

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

(2013) Robert J. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity

(2013) Markus A. Seeger et al.   PROTEIN SCIENCE

Asymmetry in the Homodimeric ABC Transporter MsbA Recognized by a DARPin

(2012) Anshumali Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

(2012) Markus A. Seeger et al.   PLoS One

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

Analysis and Modeling of the Variable Region of Camelid Single-Domain Antibodies

(2011) A. Sircar et al.   JOURNAL OF IMMUNOLOGY

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

(2011) Akiko Koide et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins

(2011) Shahir S Rizk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

(2011) Daniela Alberati et al.   NEUROPHARMACOLOGY

Position-specific propensities of amino acids in the beta-strand

(2010) Nicholus Bhattacharjee et al.   BMC STRUCTURAL BIOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of full-length KcsA in its closed conformation

(2009) S. Uysal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

(2009) D. Schonfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces

(2008) Ryan N. Gilbreth et al.   JOURNAL OF MOLECULAR BIOLOGY