Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

Bispecific Designed Ankyrin Repeat Proteins (DARPins) Targeting Epidermal Growth Factor Receptor Inhibit A431 Cell Proliferation and Receptor Recycling

(2011) Ykelien L. Boersma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency

(2011) Nikolas Stefan et al.   JOURNAL OF MOLECULAR BIOLOGY

Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface

(2011) Nicole Monroe et al.   JOURNAL OF STRUCTURAL BIOLOGY

Rapid identification of recombinant Fabs that bind to membrane proteins

(2011) JungMin Kim et al.   METHODS

Optimized Purification of a Heterodimeric ABC Transporter in a Highly Stable Form Amenable to 2-D Crystallization

(2011) Carmen Galián et al.   PLoS One

Snapshots of the maltose transporter during ATP hydrolysis

(2011) M. L. Oldham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient production of antibodies against a mammalian integral membrane protein by phage display

(2011) Isidro Hötzel et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Moderate Increase in Mdr1a/1b Expression Causes In vivo Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer

(2009) M. Pajic et al.   CANCER RESEARCH

Structure of a multidrug transporter

(2009) Michael M Gottesman et al.   NATURE BIOTECHNOLOGY

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

(2009) Nelson P Barrera et al.   NATURE METHODS

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Multidrug ABC Transporter with a Taste for Salt

(2009) Saroj Velamakanni et al.   PLoS One

Crystal structure of full-length KcsA in its closed conformation

(2009) S. Uysal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection and characterization of DARPins specific for the neurotensin receptor 1

(2009) P. Milovnik et al.   PROTEIN ENGINEERING DESIGN & SELECTION

ABC transporters: a riddle wrapped in a mystery inside an enigma

(2009) Peter M. Jones et al.   TRENDS IN BIOCHEMICAL SCIENCES

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

(2009) Daniel A.P. Gutmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum

(2008) Chikashi Toyoshima   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Functional Role of Transmembrane Helix 6 in Drug Binding and Transport by the ABC Transporter MsbA†

(2008) Barbara Woebking et al.   BIOCHEMISTRY

Molecular basis of multidrug transport by ABC transporters

(2008) Markus A. Seeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

(2008) Robert Ernst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-Assisted Crystallography with DARPins

(2008) Gaby Sennhauser et al.   STRUCTURE

On the energy-dependence of Hoechst 33342 transport by the ABC transporter LmrA

(2007) Henrietta Venter et al.   BIOCHEMICAL PHARMACOLOGY

Stabilizing Ionic Interactions in a Full-consensus Ankyrin Repeat Protein

(2007) Tobias Merz et al.   JOURNAL OF MOLECULAR BIOLOGY