TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

FACT is a sensor of DNA torsional stress in eukaryotic cells

(2017) Alfiya Safina et al.   NUCLEIC ACIDS RESEARCH

Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy

(2017) Maria Valieva et al.   Cancers

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models

(2016) Josephine Kam Tai Dermawan et al.   CANCER RESEARCH

The CENP-T/-W complex is a binding partner of the histone chaperone FACT

(2016) Lisa Prendergast et al.   GENES & DEVELOPMENT

Integrated molecular mechanism directing nucleosome reorganization by human FACT

(2016) Yasuo Tsunaka et al.   GENES & DEVELOPMENT

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

(2016) Olga A Guryanova et al.   NATURE MEDICINE

Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma

(2016) Tara A. Barone et al.   NEURO-ONCOLOGY

Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance

(2016) E. A. Miska et al.   SCIENCE

Maintenance of Genome Stability

(2016) Jiadong Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

The Mammalian Blood-Testis Barrier: Its Biology and Regulation

(2015) Dolores D. Mruk et al.   ENDOCRINE REVIEWS

FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs

(2015) David J. Kemble et al.   MOLECULAR CELL

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

(2015) Daniel R. Carter et al.   Science Translational Medicine

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells

(2015) Henry Garcia et al.   Oncotarget

Sailfish enables alignment-free isoform quantification from RNA-seq reads using lightweight algorithms

(2014) Rob Patro et al.   NATURE BIOTECHNOLOGY

Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I

(2014) Shinichi Kadota et al.   NUCLEIC ACIDS RESEARCH

Epigenetic inheritance: histone bookmarks across generations

(2014) Eric I. Campos et al.   TRENDS IN CELL BIOLOGY

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

Structural insights into the histone H1-nucleosome complex

(2013) B.-R. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model based criterion for gene expression calls using RNA-seq data

(2013) Günter P. Wagner et al.   THEORY IN BIOSCIENCES

Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers

(2013) Henry Garcia et al.   Cell Reports

Targeting FACT Complex Suppresses Mammary Tumorigenesis in Her2/neu Transgenic Mice

(2012) I. E. Koman et al.   Cancer Prevention Research

Progress made in the reprogramming field: new factors, new strategies and a new outlook

(2012) Samer MI Hussein et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Retroviral DNA Methylation and Epigenetic Repression Are Mediated by the Antiviral Host Protein Daxx

(2012) N. Shalginskikh et al.   JOURNAL OF VIROLOGY

p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs

(2012) K. I. Leonova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Activation of p53 in Cancer Cells

(2011) Mohammad Athar et al.   CURRENT PHARMACEUTICAL DESIGN

The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization

(2011) Duane D. Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response Induces IFN

(2011) Sabrina Brzostek-Racine et al.   JOURNAL OF IMMUNOLOGY

The Role of Nuclear Factor κB in the Interferon Response

(2011) Lawrence M. Pfeffer   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Curaxins: Anticancer Compounds That Simultaneously Suppress NF- B and Activate p53 by Targeting FACT

(2011) A. V. Gasparian et al.   Science Translational Medicine

SINEs

(2011) Dmitri A. Kramerov et al.   Wiley Interdisciplinary Reviews-RNA

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome

(2010) S. H. Syed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in understanding genome maintenance

(2010) Kyle M Miller   GENOME BIOLOGY

Synthetic and Natural Immunomodulators Acting as Interferon Inducers

(2009) Dmytro Silin et al.   CURRENT PHARMACEUTICAL DESIGN

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of a Functional Network of Human Epigenetic Silencing Factors

(2009) Andrey Poleshko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-H–containing Complex Facilitates Centromere Deposition of CENP-A in Cooperation with FACT and CHD1

(2009) Masahiro Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Histone Chaperone Spt16 Promotes Redeposition of the Original H3-H4 Histones Evicted by Elongating RNA Polymerase

(2009) Adil Jamai et al.   MOLECULAR CELL

The Nucleosome Family: Dynamic and Growing

(2009) Jordanka Zlatanova et al.   STRUCTURE

Sperm Chromatin: Fig. 1.

(2008) Tammy F. Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

A universal classification of eukaryotic transposable elements implemented in Repbase

(2008) Vladimir V. Kapitonov et al.   NATURE REVIEWS GENETICS