Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults

(2017) D. James Cooper et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model

(2017) Kent R. Zettel et al.   SHOCK

Red Blood Cell Storage Lesion

(2017) Daryl J. Kor et al.   Bosnian Journal of Basic Medical Sciences

Cell-free hemoglobin: a novel mediator of acute lung injury

(2016) Ciara M. Shaver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red CellsClinical Perspective

(2016) Jan A. Graw et al.   CIRCULATION

Prolonged red cell storage before transfusion increases extravascular hemolysis

(2016) Francesca Rapido et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

(2016) Rui Martins et al.   NATURE IMMUNOLOGY

Red blood cells stored 35 days or more are associated with adverse outcomes in high-risk patients

(2016) Ruchika Goel et al.   TRANSFUSION

Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices

(2016) Joo-Yeun Oh et al.   Redox Biology

Peroxiredoxin-2 Recycling Is Inhibited During Erythrocyte Storage

(2015) Victoria M. Harper et al.   ANTIOXIDANTS & REDOX SIGNALING

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

(2015) P. E. Alexander et al.   BLOOD

Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma–hemorrhage

(2015) Ryan Stapley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

(2015) John B. Holcomb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Age of Transfused Blood in Critically Ill Adults

(2015) Jacques Lacroix et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Red-Cell Storage Duration on Patients Undergoing Cardiac Surgery

(2015) Marie E. Steiner et al.   NEW ENGLAND JOURNAL OF MEDICINE

2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium

(2015) Steven L. Spitalnik et al.   TRANSFUSION

Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model

(2015) Steven B. Solomon et al.   TRANSFUSION

Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements

(2015) Joo-Yeun Oh et al.   TRANSFUSION

Red Blood Cell Storage Duration and Trauma

(2015) Rosemary L. Sparrow   TRANSFUSION MEDICINE REVIEWS

Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

(2014) Danielle Y. Qing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heat-shock Response Increases Lung Injury Caused by Pseudomonas aeruginosa via an Interleukin-10-dependent Mechanism in Mice

(2014) Michel Carles et al.   ANESTHESIOLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury

(2013) Ming-Yuan Jian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

(2013) Jean-Marc Tadie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

(2013) A. Danesh et al.   BLOOD

Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia

(2013) I. Cortes-Puch et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Adverse Effects of Hemorrhagic Shock Resuscitation With Stored Blood Are Ameliorated by Inhaled Nitric Oxide in Lambs*

(2013) David M. Baron et al.   CRITICAL CARE MEDICINE

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

The deleterious effect of red blood cell storage on microvascular response to transfusion

(2013) Jordan A. Weinberg et al.   Journal of Trauma and Acute Care Surgery

Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation

(2013) Jason T. Alexander et al.   TRANSFUSION

Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity

(2012) Ryan Stapley et al.   BIOCHEMICAL JOURNAL

Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia

(2012) S. B. Solomon et al.   BLOOD

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resuscitation with washed aged packed red blood cell units decreases the proinflammatory response in mice after hemorrhage

(2012) Ritha M. Belizaire et al.   Journal of Trauma and Acute Care Surgery

Impact on storage quality of red blood cells and platelets by ultrahigh-frequency radiofrequency identification tags

(2012) Quan-Li Wang et al.   TRANSFUSION

Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing

(2011) Jean-Marc Tadié et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics

(2011) A. D'Alessandro et al.   HAEMATOLOGICA

Microvascular Response to Red Blood Cell Transfusion in Trauma Patients

(2011) Jordan A. Weinberg et al.   SHOCK

Red blood cell age and potentiation of transfusion-related pathology in trauma patients

(2011) Jordan A. Weinberg et al.   TRANSFUSION

Microparticles in stored red blood cells as potential mediators of transfusion complications

(2011) Wenche Jy et al.   TRANSFUSION

Transfusion-Related Acute Lung Injury in a Rat Model of Trauma-Hemorrhage

(2011) Susannah E. Nicholson et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

(2010) E. A. Hod et al.   BLOOD

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients

(2010) France Gauvin et al.   TRANSFUSION

Duration of Red Cell Storage Influences Mortality After Trauma

(2010) Jordan A. Weinberg et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Age of Transfused Blood: An Independent Predictor of Mortality Despite Universal Leukoreduction

(2009) Jordan A. Weinberg et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation

(2008) N. S. Mangalmurti et al.   BLOOD

Duration of Red-Cell Storage and Complications after Cardiac Surgery

(2008) Colleen Gorman Koch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transfusions in the Less Severely Injured: Does Age of Transfused Blood Affect Outcomes?

(2008) Jordan A. Weinberg et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE