Sequence features governing aggregation or degradation of prion-like proteins

Proteolysis suppresses spontaneous prion generation in yeast

(2017) Atsushi Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress

(2017) Tatiana A. Chernova et al.   Cell Reports

Genetic interaction of hnRNPA2B1 and DNAJB6 in aDrosophilamodel of multisystem proteinopathy

(2016) Songqing Li et al.   HUMAN MOLECULAR GENETICS

The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins

(2016) Jerson L. Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Yeast and Fungal Prions

(2016) Reed B. Wickner   Cold Spring Harbor Perspectives in Biology

Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae

(2016) Anton A. Nizhnikov et al.   PLoS Genetics

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Hsp90 interaction with clients

(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Legal but lethal: functional protein aggregation at the verge of toxicity

(2015) Angelika Falsone et al.   Frontiers in Cellular Neuroscience

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

(2014) A. K. Lancaster et al.   BIOINFORMATICS

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis

(2014) John Ravits   EXPERIMENTAL NEUROLOGY

The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility

(2014) P. S. Gallagher et al.   JOURNAL OF CELL SCIENCE

Distinct Amino Acid Compositional Requirements for Formation and Maintenance of the [PSI+] Prion in Yeast

(2014) Kyle S. MacLea et al.   MOLECULAR AND CELLULAR BIOLOGY

Increasing Prion Propensity by Hydrophobic Insertion

(2014) Aaron C. Gonzalez Nelson et al.   PLoS One

Structural Basis for Protein Antiaggregation Activity of the Trigger Factor Chaperone

(2014) T. Saio et al.   SCIENCE

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Amyloid-associated activity contributes to the severity and toxicity of a prion phenotype

(2014) John A. Pezza et al.   Nature Communications

Global Proteome Turnover Analyses of the Yeasts S. cerevisiae and S. pombe

(2014) Romain Christiano et al.   Cell Reports

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Substrate Recognition in Nuclear Protein Quality Control Degradation Is Governed by Exposed Hydrophobicity That Correlates with Aggregation and Insolubility

(2013) Eric K. Fredrickson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes

(2013) Katrin Juenemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

(2013) Andrey S Tsvetkov et al.   Nature Chemical Biology

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Cellular mechanisms of protein aggregate propagation

(2012) Brandon B. Holmes et al.   CURRENT OPINION IN NEUROLOGY

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion formation by a yeast GLFG nucleoporin

(2012) Randal Halfmann et al.   Prion

De novo design of synthetic prion domains

(2012) J. A. Toombs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis

(2011) N. Ticozzi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

(2011) Manuela Neumann et al.   BRAIN

Exposed hydrophobicity is a key determinant of nuclear quality control degradation

(2011) Eric K. Fredrickson et al.   MOLECULAR BIOLOGY OF THE CELL

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The effects of amino acid composition on yeast prion formation and prion domain interactions

(2010) Eric D. Ross et al.   Prion

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

The Spontaneous Appearance Rate of the Yeast Prion [PSI+] and Its Implications for the Evolution of the Evolvability Properties of the [PSI+] System

(2009) A. K. Lancaster et al.   GENETICS

Compositional Determinants of Prion Formation in Yeast

(2009) J. A. Toombs et al.   MOLECULAR AND CELLULAR BIOLOGY

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

(2009) Basant K. Patel et al.   NATURE CELL BIOLOGY

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

GroEL Recognizes an Amphipathic Helix and Binds to the Hydrophobic Side

(2008) Yali Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

(2008) Zhiqiang Du et al.   NATURE GENETICS