Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes

Proteasomal AAA-ATPases: Structure and function

(2011) Shoshana Bar-Nun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure and function of tripeptidyl peptidase II, a giant cytosolic protease

(2011) Beate Rockel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein

(2011) Barbara Baldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Neurotoxic protein oligomerisation associated with polyglutamine diseases

(2010) Sarah L. Hands et al.   ACTA NEUROPATHOLOGICA

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

(2010) Bogdan I. Florea et al.   CHEMISTRY & BIOLOGY

Inhibiting the ubiquitin–proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

(2010) Xiang Li et al.   HUMAN MOLECULAR GENETICS

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

(2010) Fiona M. Menzies et al.   HUMAN MOLECULAR GENETICS

Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death

(2010) Katrin Juenemann et al.   NEUROTOXICITY RESEARCH

Characterization of a REG/PA28 Proteasome Activator Homolog inDictyostelium discoideumIndicates that the Ubiquitin- and ATP-Independent REGγ Proteasome Is an Ancient Nuclear Protease

(2009) Patrick Masson et al.   EUKARYOTIC CELL

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

(2009) M. Raspe et al.   JOURNAL OF CELL SCIENCE

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proteasome 11S regulator subunit REGα (PA28α) is a heptamer

(2009) Steven C. Johnston et al.   PROTEIN SCIENCE

Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones

(2008) Erwann Rousseau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomes Cleave at Multiple Sites within Polyglutamine Tracts

(2008) Gregory Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY