The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection

(2016) Sotirios Botsios et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation

(2016) Rubén Hervás et al.   PLOS BIOLOGY

Prions: What Are They Good For?

(2015) Kausik Si   Annual Review of Cell and Developmental Biology

The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity

(2015) Gal Herzog et al.   BIOCHEMISTRY

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis

(2015) Luke E. Berchowitz et al.   CELL

Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator

(2015) Mohammed Repon Khan et al.   CELL

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

(2015) Siheng Xiang et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments

(2015) Fanchi Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Yeast Prions: Structure, Biology, and Prion-Handling Systems

(2015) Reed B. Wickner et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Extracellular DNA facilitates the formation of functional amyloids inStaphylococcus aureusbiofilms

(2015) Kelly Schwartz et al.   MOLECULAR MICROBIOLOGY

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3

(2015) Luana Fioriti et al.   NEURON

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

(2015) GuoZhen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease

(2015) Rodrigo Morales et al.   Scientific Reports

Synthetic Scrapie Infectivity: Interaction between Recombinant PrP and Scrapie Brain-Derived RNA

(2015) Steve Simoneau et al.   Virulence

SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3

(2015) Bettina Drisaldi et al.   Cell Reports

Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion Protein

(2015) Saurabh Srivastava et al.   PLoS One

Heparin binding confers prion stability and impairs its aggregation

(2014) Tuane C. R. G. Vieira et al.   FASEB JOURNAL

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

Assemblages: Functional units formed by cellular phase separation

(2014) Jeffrey A. Toretsky et al.   JOURNAL OF CELL BIOLOGY

G-quadruplexes within prion mRNA: the missing link in prion disease?

(2014) René C.L. Olsthoorn   NUCLEIC ACIDS RESEARCH

Shaking Alone Induces De Novo Conversion of Recombinant Prion Proteins to β-Sheet Rich Oligomers and Fibrils

(2014) Carol L. Ladner-Keay et al.   PLoS One

The aggregation of mutant p53 produces prion-like properties in cancer

(2014) Luciana P Rangel et al.   Prion

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Stress Granules and RNA-Binding Proteins in Neurodegeneration: A Mini-Review

(2013) Tara Vanderweyde et al.   GERONTOLOGY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53

(2013) Karolyn J. Forget et al.   PLoS One

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

(2012) Cristian A. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonspecific Prion Protein–Nucleic Acid Interactions Lead to Different Aggregates and Cytotoxic Species

(2012) Bruno Macedo et al.   BIOCHEMISTRY

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase

(2012) Estefania P. C. Azevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells

(2012) Claudia Colombrita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strain-Specific Role of RNAs in Prion Replication

(2012) P. Saa et al.   JOURNAL OF VIROLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Cross-talk between prion protein and quadruplex-forming nucleic acids: a dynamic complex formation

(2012) Paola Cavaliere et al.   NUCLEIC ACIDS RESEARCH

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

(2012) R. Wilcken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

The role of RNA in mammalian prion protein conversion

(2011) Mariana P. B. Gomes et al.   Wiley Interdisciplinary Reviews-RNA

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

Cellular factors implicated in prion replication

(2010) Karim Abid et al.   FEBS LETTERS

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

(2010) Claudia B. Levy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

(2010) Tuane C. R. G. Vieira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

(2009) Jerson L. Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation

(2009) Daniella Ishimaru et al.   BIOCHEMISTRY

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

PrP interactions with nucleic acids and glycosaminoglycans in function and disease

(2009) Jerson et al.   Frontiers in Bioscience-Landmark

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

(2009) Muralidhar et al.   Frontiers in Bioscience-Landmark

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

(2009) T. Mashima et al.   NUCLEIC ACIDS RESEARCH

The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies

(2008) Stefania Rigacci et al.   BIOPHYSICAL JOURNAL

Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells

(2008) Shaoman Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

(2008) Mariana P. B. Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner

(2008) C. L. Benn et al.   JOURNAL OF NEUROSCIENCE

Intriguing nucleic-acid-binding features of mammalian prion protein

(2008) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES