Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans

(2017) Matthew Z. Anderson et al.   MICROBIOLOGY-SGM

Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator

(2017) Isabel Nocedal et al.   eLife

Rewiring of the Ppr1 Zinc Cluster Transcription Factor from Purine Catabolism to Pyrimidine Biogenesis in the Saccharomycetaceae

(2016) Walters Aji Tebung et al.   CURRENT BIOLOGY

Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction

(2016) Joy L. Nishikawa et al.   NATURE

TheCandidaGenome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

(2016) Marek S. Skrzypek et al.   NUCLEIC ACIDS RESEARCH

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress

(2016) Teresa R. O’Meara et al.   PLoS Genetics

Trafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals

(2015) Arturo Luna-Tapia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Nontoxic antimicrobials that evade drug resistance

(2015) Stephen A Davis et al.   Nature Chemical Biology

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

(2015) Nicole Robbins et al.   Cell Reports

Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics

(2014) Jessica C.S. Brown et al.   CELL

UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans

(2014) Erin M. Vasicek et al.   EUKARYOTIC CELL

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

(2014) Benjamin D. Harrison et al.   PLOS BIOLOGY

The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens

(2013) Leah E Cowen   CURRENT OPINION IN MICROBIOLOGY

Role of Retrograde Trafficking in Stress Response, Host Cell Interactions, and Virulence of Candida albicans

(2013) Yaoping Liu et al.   EUKARYOTIC CELL

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Heat Shock Protein 90 Is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus

(2012) Frédéric Lamoth et al.   EUKARYOTIC CELL

Participation of CWI, HOG and Calcineurin pathways in the tolerance of Saccharomyces cerevisiae to low pH by inorganic acid

(2012) R.M. Lucena et al.   JOURNAL OF APPLIED MICROBIOLOGY

Advancing the development of tuberculosis therapy

(2012) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Tackling Human Fungal Infections

(2012) G. D. Brown et al.   SCIENCE

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans

(2010) C. M. Martel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

The Candida albicans Rgd1 is a RhoGAP protein involved in the control of filamentous growth

(2010) Frédérique Ness et al.   FUNGAL GENETICS AND BIOLOGY

Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2

(2010) D. H. M. L. P. Navarathna et al.   MICROBIOLOGY-SGM

Intercalation of a new tier of transcription regulation into an ancient circuit

(2010) Lauren N. Booth et al.   NATURE

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

(2010) Shantelle L. LaFayette et al.   PLoS Pathogens

Our Paths Might Cross: the Role of the Fungal Cell Wall Integrity Pathway in Stress Response and Cross Talk with Other Stress Response Pathways

(2009) Beth Burgwyn Fuchs et al.   EUKARYOTIC CELL

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

(2009) Richard T. Eastman et al.   NATURE REVIEWS MICROBIOLOGY

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

(2009) Leah E. Cowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

A Phenotypic Profile of the Candida albicans Regulatory Network

(2009) Oliver R. Homann et al.   PLoS Genetics

Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

(2009) Leah E. Cowen   PLoS Pathogens

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans

(2008) Oliver W. Liu et al.   CELL

Phosphoinositides Affect both the Cellular Distribution and Activity of the F-BAR-containing RhoGAP Rgd1p in Yeast

(2008) Valérie Prouzet-Mauléon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY