Nontoxic antimicrobials that evade drug resistance

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Amphotericin forms an extramembranous and fungicidal sterol sponge

(2014) Thomas M Anderson et al.   Nature Chemical Biology

Targeting molecular networks for drug research

(2014) José P. Pinto et al.   Frontiers in Genetics

Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group

(2013) Anna N. Tevyashova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells

(2013) Brandon C. Wilcock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

(2013) J.E. Cortes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

(2013) Benjamin Matteson Vincent et al.   PLOS BIOLOGY

Posaconazole Pharmacodynamic Target Determination against Wild-Type andCyp51Mutant Isolates of Aspergillus fumigatus in anIn VivoModel of Invasive Pulmonary Aspergillosis

(2012) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Controlled Crystallization, Structure, and Molecular Properties of Iodoacetylamphotericin B

(2012) Katarzyna N. Jarzembska et al.   CRYSTAL GROWTH & DESIGN

Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004–2008

(2012) Michael Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Wild-Type MIC Distributions and Epidemiological Cutoff Values for Amphotericin B, Flucytosine, and Itraconazole and Candida spp. as Determined by CLSI Broth Microdilution

(2012) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor

(2012) Pintipa Grongsaard et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

(2011) Michael A. Pfaller   AMERICAN JOURNAL OF MEDICINE

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities

(2011) D. S. Palacios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Lipids Can Phase-separate into Micrometer-scale Membrane Domains

(2010) Christian Klose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Do Sterols Determine the Antifungal Activity of Amphotericin B? Free Energy of Binding between the Drug and Its Membrane Targets

(2010) Anna Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic response to low-level toxicant exposure in a novel renal tubuleepithelial cell system

(2010) James Keith Ellis et al.   Molecular BioSystems

Synthesis and biological evaluation of amphotericin B derivatives

(2010) Astrid A. Volmer et al.   NATURAL PRODUCT REPORTS

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs

(2010) Yong-Qiang Zhang et al.   PLoS Pathogens

Engineered Synthesis of 7-Oxo- and 15-Deoxy-15-Oxo-Amphotericins: Insights into Structure-Activity Relationships in Polyene Antibiotics

(2008) Patrick Power et al.   CHEMISTRY & BIOLOGY

Synthesis and In Vitro Biological Properties of Novel Cationic Derivatives of Amphotericin B

(2008) Valérie Paquet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast

(2008) Hui Jin et al.   JOURNAL OF CELL BIOLOGY

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

(2008) M. Neant-Fery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA