DrosophilaTRPML Forms PI(3,5)P2-activated Cation Channels in Both Endolysosomes and Plasma Membrane

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Feast or famine

(2012) Kartik Venkatachalam et al.   Autophagy

Drosophila TRPML Is Required for TORC1 Activation

(2012) Ching-On Wong et al.   CURRENT BIOLOGY

Constitutive Activity of TRPML2 and TRPML3 Channels versus Activation by Low Extracellular Sodium and Small Molecules

(2012) C. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

CUP-5, theC. elegansortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes

(2011) Tao Sun et al.   Autophagy

Lysosomal Membrane Protein Composition, Acidic pH and Sterol Content are Regulated via a Light-Dependent Pathway in Metazoan Cells

(2011) M. G. Swetha et al.   TRAFFIC

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

A Role for the Ca2+ Channel TRPML1 in Gastric Acid Secretion, Based on Analysis of Knockout Mice

(2010) Manjari Chandra et al.   GASTROENTEROLOGY

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration

(2009) Shaya Lev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis

(2009) Xian-ping Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of the Mcoln1−/− Knockout Mouse Model of Mucolipidosis Type IV

(2009) Matthew C. Micsenyi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Ca2+Channel TRPML3 Regulates Membrane Trafficking and Autophagy

(2009) Hyun Jin Kim et al.   TRAFFIC

Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells

(2008) Kartik Venkatachalam et al.   CELL

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

(2008) Hyun Jin Kim et al.   EMBO JOURNAL

Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations

(2008) Rui Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

(2008) Thirumalini Vaithianathan et al.   JOURNAL OF GENERAL PHYSIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE