Genetics of Multiple Sclerosis: An Overview and New Directions

Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study

(2016) Gongbu Pan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Publicly Available Data Provide Evidence against NR1H3 R415Q Causing Multiple Sclerosis

(2016) Eric Vallabh Minikel et al.   NEURON

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk

(2016) Jack Antel et al.   NEURON

Nuclear Receptor NR1H3 in Familial Multiple Sclerosis

(2016) Zhe Wang et al.   NEURON

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

(2016) T. F. M. Andlauer et al.   Science Advances

Genetic contribution to multiple sclerosis risk among Ashkenazi Jews

(2015) Pouya Khankhanian et al.   BMC Medical Genetics

An ImmunoChip study of multiple sclerosis risk in African Americans

(2015) Noriko Isobe et al.   BRAIN

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis

(2015) An Goris et al.   BRAIN

Genetic associations with brain cortical thickness in multiple sclerosis

(2015) T. Matsushita et al.   GENES BRAIN AND BEHAVIOR

The immunogenetics of multiple sclerosis: A comprehensive review

(2015) Jill A. Hollenbach et al.   JOURNAL OF AUTOIMMUNITY

Burden of risk variants correlates with phenotype of multiple sclerosis

(2015) Kelly Hilven et al.   Multiple Sclerosis Journal

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Class II HLA interactions modulate genetic risk for multiple sclerosis

(2015) Loukas Moutsianas et al.   NATURE GENETICS

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

(2015) Lauren E. Mokry et al.   PLOS MEDICINE

Burden of risk variants correlates with phenotype of multiple sclerosis

(2015) Kelly Hilven et al.   Multiple Sclerosis Journal

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

(2014) Maureen D. Mayes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci

(2014) Kamil Slowikowski et al.   BIOINFORMATICS

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden

(2014) Helga Westerlind et al.   BRAIN

Shared environmental effects on multiple sclerosis susceptibility: conflicting evidence from twin studies

(2014) Corrado Fagnani et al.   BRAIN

Reply: Shared environmental effects on multiple sclerosis susceptibility: conflicting evidence from twin studies

(2014) Helga Westerlind et al.   BRAIN

Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses

(2014) L. M. Maier et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

(2014) O A Andreassen et al.   MOLECULAR PSYCHIATRY

A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands

(2014) Mercedes Delgado-García et al.   Multiple Sclerosis Journal

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis

(2013) et al.   BRAIN

A genome-wide association study of brain lesion distribution in multiple sclerosis

(2013) Pierre-Antoine Gourraud et al.   BRAIN

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

(2013) A. Goris et al.   HUMAN MOLECULAR GENETICS

Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis

(2013) Hanne F Harbo et al.   Multiple Sclerosis Journal

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

(2013) Jimmy Z Liu et al.   NATURE GENETICS

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Genetic risk variants in African Americans with multiple sclerosis

(2013) N. Isobe et al.   NEUROLOGY

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

(2013) Nikolaos A. Patsopoulos et al.   PLoS Genetics

Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis

(2012) Dorothea Buck et al.   ANNALS OF NEUROLOGY

No evidence of association between mutant alleles of theCYP27B1gene and multiple sclerosis

(2012) Maria Ban et al.   ANNALS OF NEUROLOGY

No evidence for a role of rareCYP27B1functional variations in multiple sclerosis

(2012) Nadia Barizzone et al.   ANNALS OF NEUROLOGY

A genome-wide association study in progressive multiple sclerosis

(2012) Filippo Martinelli-Boneschi et al.   Multiple Sclerosis Journal

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

(2012) Jimmy Z Liu et al.   NATURE GENETICS

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Modelling Genetic Susceptibility to Multiple Sclerosis with Family Data

(2012) Cullen O’Gorman et al.   NEUROEPIDEMIOLOGY

Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1

(2012) Fuencisla Matesanz et al.   PLoS One

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets

(2011) Xinli Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

(2011) Sreeram V. Ramagopalan et al.   ANNALS OF NEUROLOGY

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

Genome-wide association study of severity in multiple sclerosis

(2011)   GENES AND IMMUNITY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

(2010) Eveliina Jakkula et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aggregation of multiple sclerosis genetic risk variants in multiple and single case families

(2010) Pierre-Antoine Gourraud et al.   ANNALS OF NEUROLOGY

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

(2010) Sandra Nischwitz et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluation of the established non-MHC multiple sclerosis loci in an Indian population

(2010) Lekha Pandit et al.   Multiple Sclerosis Journal

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients

(2010) Cathy J. Jensen et al.   PLoS One

Multiple sclerosis susceptibility alleles in African Americans

(2009) B A Johnson et al.   GENES AND IMMUNITY

The HLA genomic loci map: expression, interaction, diversity and disease

(2009) Takashi Shiina et al.   JOURNAL OF HUMAN GENETICS

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

(2009) Philip L De Jager et al.   LANCET NEUROLOGY

Twin studies and the heritability of MS: a conclusion

(2009) CH Hawkes et al.   Multiple Sclerosis Journal

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

The role of the CD58 locus in multiple sclerosis

(2009) P. L. De Jager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

(2009) M. R. Lincoln et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: a nationwide cohort study in Denmark

(2008) NM Nielsen et al.   Multiple Sclerosis Journal

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

(2008) Manuel Comabella et al.   PLoS One

A genome scan in a single pedigree with a high prevalence of multiple sclerosis

(2007) D A Dyment et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY