Biological Stimulus-Driven Assembly/Disassembly of Functional Nanoparticles for Targeted Delivery, Controlled Activation, and Bioelimination

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

(2018) Qing Chen et al.   ACS Nano

Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy

(2018) Liying Wang et al.   BIOMATERIALS

Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy

(2018) Longfei Tan et al.   BIOMATERIALS

Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics

(2018) Yong'an Tang et al.   BIOMATERIALS

Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumors

(2018) Jindan Li et al.   CHEMICAL COMMUNICATIONS

Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold–Copper Sulfide Yolk–Shell Nanoparticles for Chemophototherapy of Cancer

(2018) Yun Chang et al.   NANO LETTERS

Renal-Clearable Hollow Bismuth Subcarbonate Nanotubes for Tumor Targeted Computed Tomography Imaging and Chemoradiotherapy

(2018) Xi Hu et al.   NANO LETTERS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

(2018) Hadas Gibori et al.   Nature Communications

Advanced smart-photosensitizers for more effective cancer treatment

(2018) Wooram Park et al.   Biomaterials Science

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

(2018) Longfa Kou et al.   Frontiers in Pharmacology

Metalloporphyrin-Encapsulated Biodegradable Nanosystems for Highly Efficient Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy

(2017) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanostructured Phthalocyanine Assemblies with Protein-Driven Switchable Photoactivities for Biophotonic Imaging and Therapy

(2017) Xingshu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor-Targeted and Clearable Human Protein-Based MRI Nanoprobes

(2017) Yang Zhao et al.   NANO LETTERS

In vivo aggregation-induced transition between T1and T2relaxations of magnetic ultra-small iron oxide nanoparticles in tumor microenvironment

(2017) Huige Zhou et al.   Nanoscale

Light-up probe based on AIEgens: dual signal turn-on for caspase cascade activation monitoring

(2017) Youyong Yuan et al.   Chemical Science

Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy

(2017) Zhengze Yu et al.   Chemical Science

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Size-Tuning Ionization To Optimize Gold Nanoparticles for Simultaneous Enhanced CT Imaging and Radiotherapy

(2016) Yan Dou et al.   ACS Nano

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging-Guided Tumor Photothermal Therapy

(2016) Linlin Li et al.   ACS Nano

Osmotic Power Generation with Positively and Negatively Charged 2D Nanofluidic Membrane Pairs

(2016) Jinzhao Ji et al.   ADVANCED FUNCTIONAL MATERIALS

Multifunctional Nanoparticles Self-Assembled from Small Organic Building Blocks for Biomedicine

(2016) Pengyao Xing et al.   ADVANCED MATERIALS

Activatable molecular MRI nanoprobe for tumor cell imaging based on gadolinium oxide and iron oxide nanoparticle

(2016) Jingjing Li et al.   BIOSENSORS & BIOELECTRONICS

Beyond “turn-on” readout: from zero background to signal amplification by combination of magnetic separation and plasmon enhanced fluorescence

(2016) Suqin Gong et al.   CHEMICAL COMMUNICATIONS

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

“Manganese Extraction” Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles

(2016) Luodan Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance

(2016) Huaimin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

(2016) Cong Luo et al.   NANO LETTERS

Photoacoustic Molecular Imaging: From Multiscale Biomedical Applications Towards Early-Stage Theranostics

(2016) Yajing Liu et al.   TRENDS IN BIOTECHNOLOGY

In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

(2016) Xiangzhao Ai et al.   Nature Communications

Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

(2016) Dong-Hyun Kim et al.   Scientific Reports

Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3

(2016) Haojun Chen et al.   Theranostics

pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma

(2016) Hongping Xia et al.   ACS Central Science

Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells

(2016) Jie Zhou et al.   Chem

Cationic Conjugated Polymer/Hyaluronan-Doxorubicin Complex for Sensitive Fluorescence Detection of Hyaluronidase and Tumor-Targeting Drug Delivery and Imaging

(2015) Yanqin Huang et al.   ACS Applied Materials & Interfaces

Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics

(2015) Peng Huang et al.   ACS Nano

Redox-responsive micelles self-assembled from dynamic covalent block copolymers for intracellular drug delivery

(2015) Qinglai Yang et al.   Acta Biomaterialia

A Bio-Inspired Rod-Shaped Nanoplatform for Strongly Infecting Tumor Cells and Enhancing the Delivery Efficiency of Anticancer Drugs

(2015) Dan Li et al.   ADVANCED FUNCTIONAL MATERIALS

Self-Assembled Smart Nanocarriers for Targeted Drug Delivery

(2015) Wei Cui et al.   ADVANCED MATERIALS

Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

(2015) Cassandra E. Callmann et al.   ADVANCED MATERIALS

In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites

(2015) Di Zhang et al.   ADVANCED MATERIALS

Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance

(2015) Yue Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced NIR Radiation-Triggered Hyperthermia by Mitochondrial Targeting

(2015) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Taurine Boosts Cellular Uptake of Small d-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly

(2015) Jie Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer

(2015) Aravind Kumar Rengan et al.   NANO LETTERS

pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

(2015) Robert J. Harris et al.   NEURO-ONCOLOGY

Molecular Magnetic Resonance Imaging of Tumor Response to Therapy

(2015) Adam J. Shuhendler et al.   Scientific Reports

Shieldable Tumor Targeting Based on pH Responsive Self-Assembly/Disassembly of Gold Nanoparticles

(2014) Zhiqing Tian et al.   ACS Applied Materials & Interfaces

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma

(2014) Daishun Ling et al.   ACS Nano

DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and MicroRNA-Responsive Controlled Drug Delivery

(2014) Penghui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery

(2014) Yincheng Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CXCR4-Targeted and MMP-Responsive Iron Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging

(2014) Juan Gallo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment

(2014) Deju Ye et al.   BIOCONJUGATE CHEMISTRY

Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles

(2014) Chunli Shi et al.   BIOMATERIALS

Disassembly-Driven Fluorescence Turn-on of Polymerized Micelles by Reductive Stimuli in Living Cells

(2014) Yosuke Niko et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

(2014) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

(2014) Daishun Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)–Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo

(2014) Xingxing Chuan et al.   MOLECULAR PHARMACEUTICS

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

(2014) Deju Ye et al.   Nature Chemistry

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

(2014) Brendan P. Purcell et al.   NATURE MATERIALS

DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination

(2014) Leo Y. T. Chou et al.   Nature Nanotechnology

Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis

(2014) Deju Ye et al.   Chemical Science

Magneto-fluorescent core-shell supernanoparticles

(2014) Ou Chen et al.   Nature Communications

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

(2014) Ran Namgung et al.   Nature Communications

Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe

(2014) Zeinab Darwich et al.   RSC Advances

Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity

(2014) Huan Liu et al.   Journal of Materials Chemistry B

Self-Assembled Porphyrin Nanodiscs with Structure-Dependent Activation for Phototherapy and Photodiagnostic Applications

(2013) Kenneth K. Ng et al.   ACS Nano

Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue

(2013) Miao-Ping Chien et al.   ADVANCED MATERIALS

Caged Pt Nanoclusters Exhibiting Corrodibility to Exert Tumor-Inside Activation for Anticancer Chemotherapeutics

(2013) Chih-Te Chien et al.   ADVANCED MATERIALS

Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications

(2013) Tianjiao Ji et al.   ADVANCED MATERIALS

Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy

(2013) Peng Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells

(2013) Min Suk Shim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy

(2013) Qingfeng Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance

(2013) Jinbin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by in Vivo Whole Animal Imaging and ex Vivo Super-Resolution Fluorescence Imaging

(2013) Miao-Ping Chien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

(2013) Yiguang Wang et al.   NATURE MATERIALS

Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging

(2013) Tianjiao Ji et al.   Small

Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting

(2012) Daishun Ling et al.   BIOMATERIALS

Intracellular self-assembly of nanoparticles for enhancing cell uptake

(2012) Qingqing Miao et al.   CHEMICAL COMMUNICATIONS

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Biocompatible Polymeric Nanoparticles Degrade and Release Cargo in Response to Biologically Relevant Levels of Hydrogen Peroxide

(2012) Caroline de Gracia Lux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembled Plasmonic Vesicles of SERS-Encoded Amphiphilic Gold Nanoparticles for Cancer Cell Targeting and Traceable Intracellular Drug Delivery

(2012) Jibin Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli

(2012) Kejin Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Luminescent proteins for high-speed single-cell and whole-body imaging

(2012) Kenta Saito et al.   Nature Communications

Imaging enzyme-triggered self-assembly of small molecules inside live cells

(2012) Yuan Gao et al.   Nature Communications

Redox-Responsive, Core Cross-Linked Polyester Micelles

(2012) Zhonghai Zhang et al.   ACS Macro Letters

Tumor Accumulation of NIR Fluorescent PEG–PLA Nanoparticles: Impact of Particle Size and Human Xenograft Tumor Model

(2011) Andreas Schädlich et al.   ACS Nano

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Triggered disassembly of hierarchically assembled onion-like micelles into the pristine core–shell micelles via a small change in pH

(2011) Guoqiang Cai et al.   Acta Biomaterialia

Controlling Intracellular Macrocyclization for the Imaging of Protease Activity

(2011) Deju Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents

(2011) Gaolin Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inflammation Responsive Logic Gate Nanoparticles for the Delivery of Proteins

(2011) Enas A. Mahmoud et al.   BIOCONJUGATE CHEMISTRY

Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy

(2011) Jinyao Liu et al.   BIOMACROMOLECULES

Tumor accumulation and antitumor efficacy of docetaxel-loaded core-shell-corona micelles with shell-specific redox-responsive cross-links

(2011) Ahn Na Koo et al.   BIOMATERIALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Aggregation-induced emission

(2011) Yuning Hong et al.   CHEMICAL SOCIETY REVIEWS

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Controlling the Self-Assembly Structure of Magnetic Nanoparticles and Amphiphilic Block-Copolymers: From Micelles to Vesicles

(2011) Robert J. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

(2011) Georgy Mikhaylov et al.   Nature Nanotechnology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI

(2010) Jin-sil Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

(2009) Yuan Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual Redox Responsive Assemblies Formed from Diselenide Block Copolymers

(2009) Ning Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery

(2009) Ji Eun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

(2009) PV Asharani et al.   Nanomedicine

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging

(2008) Ji-Ho Park et al.   ADVANCED MATERIALS

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

In Vivo Detection of Apoptosis

(2008) F. G. Blankenberg   JOURNAL OF NUCLEAR MEDICINE