Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications

In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene

(2012) Hao Hong et al.   ACS Nano

Co-delivery Strategies Based on Multifunctional Nanocarriers for Cancer Therapy

(2012) Hao Chen et al.   CURRENT DRUG METABOLISM

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix

(2012) Mathumai Kanapathipillai et al.   NANO LETTERS

Cancer: Limitations of therapies exposed

(2012) Oriol Casanovas   NATURE

Combo combat

(2012) C. Jeffrey Brinker   NATURE MATERIALS

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine

(2012) S.-g. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antineoplastic activities of Gd@C82(OH)22 nanoparticles: tumor microenvironment regulation

(2012) YiYe Li et al.   Science China-Life Sciences

Drug Delivery: Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple-Targeted Dual-Drug Silica Nanoformulations for Theragnostics (Small 22/2012)

(2012) Srivani Veeranarayanan et al.   Small

Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells

(2012) Erik C. Dreaden et al.   Small

High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery

(2012) Jin-Ki Kim et al.   Small

Integrin Targeting for Tumor Optical Imaging

(2012) Yunpeng Ye et al.   Theranostics

Silica Nanorattle–Doxorubicin-Anchored Mesenchymal Stem Cells for Tumor-Tropic Therapy

(2011) Linlin Li et al.   ACS Nano

Chimeric Capsid Protein as a Nanocarrier for siRNA Delivery: Stability and Cellular Uptake of Encapsulated siRNA

(2011) Kyung-mi Choi et al.   ACS Nano

HER2 Expression in Breast Cancer Cells Is Downregulated Upon Active Targeting by Antibody-Engineered Multifunctional Nanoparticles in Mice

(2011) Fabio Corsi et al.   ACS Nano

EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise

(2011) Mar Creixell et al.   ACS Nano

pH-Titratable Superparamagnetic Iron Oxide for Improved Nanoparticle Accumulation in Acidic Tumor Microenvironments

(2011) Samuel H. Crayton et al.   ACS Nano

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor

(2011) Yinghuan Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers

(2011) Forrest M. Kievit et al.   ADVANCED MATERIALS

Tumor-Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging

(2011) In-Cheol Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging

(2011) Xin Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anchored Proteinase-Targetable Optomagnetic Nanoprobes for Molecular Imaging of Invasive Cancer Cells

(2011) Joseph Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

X-Ray Computed Tomography Imaging of Breast Cancer by using Targeted Peptide-Labeled Bismuth Sulfide Nanoparticles

(2011) Joseph M. Kinsella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A graphene oxide platform for energy transfer-based detection of protease activity

(2011) Juan Li et al.   BIOSENSORS & BIOELECTRONICS

Tumor cell metabolism

(2011) Susana Romero-Garcia et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Multi-modal strategies for overcoming tumor drug resistance: Hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology

(2011) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

Tumour macrophages as potential targets of bisphosphonates

(2011) Thea L Rogers et al.   Journal of Translational Medicine

Chimeric Ferritin Nanocages for Multiple Function Loading and Multimodal Imaging

(2011) Xin Lin et al.   NANO LETTERS

Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells

(2011) Huan Meng et al.   Nanomedicine-Nanotechnology Biology and Medicine

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Nanoparticles that communicate in vivo to amplify tumour targeting

(2011) Geoffrey von Maltzahn et al.   NATURE MATERIALS

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

(2011) Georgy Mikhaylov et al.   Nature Nanotechnology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilins: A New Target for Cancer Therapy

(2011) Camille Grandclement et al.   Cancers

Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives

(2010) Huan Meng et al.   ACS Nano

Pericytes and vessel maturation during tumor angiogenesis and metastasis

(2010) Ahmad Raza et al.   AMERICAN JOURNAL OF HEMATOLOGY

PET/NIRF/MRI triple functional iron oxide nanoparticles

(2010) Jin Xie et al.   BIOMATERIALS

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Cancer-associated fibroblasts are positively correlated with metastatic potential of human gastric cancers

(2010) Kangkang Zhi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

(2010) Jinjun Shi et al.   NANO LETTERS

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Environmentally responsive peptides as anticancer drug carriers☆

(2009) Suhaas Aluri et al.   ADVANCED DRUG DELIVERY REVIEWS

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The developmental roles of the extracellular matrix: beyond structure to regulation

(2009) Kwok Yeung Tsang et al.   CELL AND TISSUE RESEARCH

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

(2009) Klaus von der Mark et al.   CELL AND TISSUE RESEARCH

Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel

(2009) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas

(2009) Darya Alizadeh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

Cooperative nanomaterial system to sensitize, target, and treat tumors

(2009) J.-H. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast

(2009) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors

(2009) Steffen Eikenberry   Theoretical Biology and Medical Modelling

Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact

(2008) Surbhi Lal et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Near-Infrared-Fluorescence-Quenched Gold-Nanoparticle Imaging Probe for In Vivo Drug Screening and Protease Activity Determination

(2008) Seulki Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo

(2008) Sara Gosk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cancer and the tumor microenvironment: a review of an essential relationship

(2008) Flaubert Mbeunkui et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits

(2008) Patrick M. Winter et al.   FASEB JOURNAL

Tumor microenvironment and angiogenesis

(2008) Pia Nyberg   Frontiers in Bioscience-Landmark

Polarized immune responses differentially regulate cancer development

(2008) Magnus Johansson et al.   IMMUNOLOGICAL REVIEWS

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

(2008) E. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion

(2007) Olga Vasiljeva et al.   BIOCHIMIE