Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

(2017) Sofia Avnet et al.   INTERNATIONAL JOURNAL OF CANCER

Human adipose stem cell differentiation is highly affected by cancer cells both in vitro and in vivo: implication for autologous fat grafting

(2017) Francesca Paino et al.   Cell Death & Disease

Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development

(2017) Federica Papaccio et al.   Stem Cells Translational Medicine

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy

(2017) Yuekui Zhao et al.   Scientific Reports

The mechanism between epithelial mesenchymal transition in breast cancer and hypoxia microenvironment

(2016) Tong Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

(2016) Raffaela Fontanella et al.   CANCER LETTERS

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion

(2016) Margherita Cortini et al.   PLoS One

Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

(2016) Rebecca Macklin et al.   Oncotarget

Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells

(2016) Jir-You Wang et al.   Stem Cells Translational Medicine

3D Printing Surgical Implants at the clinic: A Experimental Study on Anterior Cruciate Ligament Reconstruction

(2016) An Liu et al.   Scientific Reports

Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial

(2015) Hanno Niess et al.   BMC CANCER

Do Mesenchymal Stromal Cells Influence Microscopic Residual or Metastatic Osteosarcoma in a Murine Model?

(2015) Megan E. Aanstoos et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases

(2015) Astra Chang et al.   CURRENT CANCER DRUG TARGETS

Mesenchymal Progenitors Expressing TRAIL Induce Apoptosis in Sarcomas

(2015) Giulia Grisendi et al.   STEM CELLS

Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma

(2015) Bo Qiao et al.   Drug Design Development and Therapy

Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment

(2014) W. Ling et al.   CANCER RESEARCH

The roles of mesenchymal stem cells in tumor inflammatory microenvironment

(2014) Zhao Sun et al.   Journal of Hematology & Oncology

Carcinoma-associated fibroblasts provide operational flexibility in metastasis

(2014) Olivier De Wever et al.   SEMINARS IN CANCER BIOLOGY

Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells

(2014) Ruth Rubio et al.   STEM CELLS

Soliciting Strategies for Developing Cell-Based Reference Materials to Advance Mesenchymal Stromal Cell Research and Clinical Translation

(2014) Sowmya Viswanathan et al.   STEM CELLS AND DEVELOPMENT

The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment

(2014) Jun Ye et al.   TUMOR BIOLOGY

Homologous mesenchymal stem cells promote the emergence and growth of pulmonary metastases of the rat osteosarcoma cell line UMR-106

(2014) PENG ZHANG et al.   Oncology Letters

Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-β/Smad2/3 pathway

(2013) Bing Tu et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

(2013) Pallavi Chaturvedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma

(2013) S. Duchi et al.   JOURNAL OF CONTROLLED RELEASE

CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF

(2013) PENG ZHANG et al.   ONCOLOGY REPORTS

Human umbilical cord wharton's jelly stem cell (hWJSC) extracts inhibit cancer cell growth in vitro

(2012) Kalamegam Gauthaman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human adipose CD34+CD90+stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues

(2012) Giuseppe A. Ferraro et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration

(2012) Alexander B Mohseny et al.   JOURNAL OF PATHOLOGY

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development

(2012) R Rubio et al.   ONCOGENE

Mesenchymal stem cells engineered for cancer therapy

(2011) Khalid Shah   ADVANCED DRUG DELIVERY REVIEWS

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

Modeling sarcomagenesis using multipotent mesenchymal stem cells

(2011) Rene Rodriguez et al.   CELL RESEARCH

Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo

(2011) Virginia Tirino et al.   FASEB JOURNAL

Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity

(2010) Pascal-David Johann et al.   BMC CANCER

Tumor associated mesenchymal stem cells protects ovarian cancer cells from hyperthermia through CXCL12

(2010) Raphael Lis et al.   INTERNATIONAL JOURNAL OF CANCER

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis

(2010) T Shimizu et al.   ONCOGENE

Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence

(2010) Pierre Perrot et al.   PLoS One

Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis

(2009) Wen-ting Xu et al.   CANCER LETTERS

In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential

(2009) Yasunori Tome et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss ofCdkn2

(2009) Alexander B Mohseny et al.   JOURNAL OF PATHOLOGY

Human CD34+/CD90+ ASCs Are Capable of Growing as Sphere Clusters, Producing High Levels of VEGF and Forming Capillaries

(2009) Francesco De Francesco et al.   PLoS One

FDA Regulation of Stem Cell-Based Products

(2009) D. W. Fink   SCIENCE