Review
Oncology
Yuanming Jing, Wenqing Liang, Lin Zhang, Junjun Tang, Zongliang Huang
Summary: Cancer stem cells modify their microenvironment by recruiting and activating specific cell types such as mesenchymal stem cells (MSCs). The interaction between cancer cells and MSCs induces a cancer stem cell phenotype.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Kun Liu, Xin Gao, Baoqiang Kang, Yunpeng Liu, Dingding Wang, Yi Wang
Summary: Exosomes are vesicles secreted by cells that play pivotal roles in intercellular communication. The exosomes secreted by tumor stem cells are important messengers involved in tumor recurrence and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fawzy Akad, Veronica Mocanu, Sorin Nicolae Peiu, Viorel Scripcariu, Bogdan Filip, Daniel Timofte, Florin Zugun-Eloae, Magdalena Cuciureanu, Monica Hancianu, Teodor Oboroceanu, Laura Condur, Radu Florin Popa
Summary: Individualized gastric cancer treatment uses targeted therapies based on the latest research. Extracellular vesicle microRNAs are biomarkers for GC prognosis. H. pylori infection influences therapeutic response and drivers of malignant changes in gastritis. Transplanted MSCs have been successfully used for gastric ulcer healing and studying their effects on tumor neovascularization and potential antiangiogenic therapies. MSCs derived from various sources have pro- and antiangiogenic effects that complement their role in immune regulation and tissue regeneration and provide further understanding of the biology of GC and resistance to antiangiogenic drugs.
Article
Cell & Tissue Engineering
Li Ba, Chunling Xue, Xuechun Li, Mingjia Zhang, Ying Yang, Qin Han, Zhao Sun, Robert Chunhua Zhao
Summary: This study demonstrates that tumor cell-derived exosomes can enhance the migration and invasion functions of human adipose-derived mesenchymal stem cells (MSCs) by affecting the expression of circular RNAs. Specifically, circ_0004303 upregulates activated leukocyte cell adhesion molecule (ALCAM) by acting as a miR-148a-3p sponge, thereby regulating the migration and invasion of MSCs. Exosomes from gastric cancer cells can influence the behavior of MSCs in adjacent tissues, suggesting a potential mechanism for tumor progression.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Medicine, Research & Experimental
V. A. Subramanian, Ravindra Kumar Bairwa, Pradeep Kumar Sharma, Bhawana Bissa
Summary: This article discusses the roles of autophagy and exosomes in the cancer cell's adaptation to the tumor microenvironment and how the two pathways are coordinately regulated to facilitate cancer cell survival.
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Review
Biochemistry & Molecular Biology
Mahdi Ahmadi, Monireh Mahmoodi, Maryam Shoaran, Fereshteh Nazari-Khanamiri, Jafar Rezaie
Summary: New therapeutic approaches are urgently needed for combating metastatic cancers, which cause over 8 million deaths per year worldwide. Mesenchymal stem cells (MSCs) have shown potential as a novel treatment option for cancer, with their exosomes playing a crucial role in regulating tumor progression. However, there is still controversy surrounding the exact association between MSC-derived exosomes and tumors. Nevertheless, the use of MSC-derived exosomes as drug delivery systems and standalone therapeutics is actively being explored, and engineering these exosomes to target tumor cells shows promise in improving the efficacy of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev, Majid Ahmadi
Summary: The interaction between the tumor microenvironment and tumor cells plays a crucial role in tumor progression, with mesenchymal stem cells (MSCs) being key players in modulating the tumor microenvironment and influencing the fate of tumor cells. MSCs exhibit dual functions in the tumor microenvironment, either promoting tumorigenicity or inhibiting tumor growth. Their ability to release mediators such as exosomes and migrate to tumor sites facilitates efficient drug delivery and targeting of migrating tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
RamaRao Malla, Kiran Puvalachetty, Rahul K. Vempati, Rakshmitha Marni, Neha Merchant, Ganji Purnachandra Nagaraju
Summary: The interplay between cancer stem cells, exosomes, and circulatory tumor cells in breast cancer has been discussed. They communicate with stromal and immune cells to promote metastasis and induce epithelial mesenchymal transition (EMT) involved in metastasis.
CLINICAL BREAST CANCER
(2022)
Review
Biochemistry & Molecular Biology
Lu Zhang, Wenmin Chen, Suling Liu, Ceshi Chen
Summary: The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence have been recognized for many decades. Due to their strong capacity for self-renewal and differentiation, BCSCs are the major reasons for poor clinical outcomes and low therapeutic response. Several hypotheses on the origin of cancer stem cells have been proposed, including critical gene mutations in stem cells, dedifferentiation of somatic cells, and cell plasticity remodeling by epithelial-mesenchymal transition (EMT) and the tumor microenvironment. Moreover, the tumor microenvironment, including cellular components and cytokines, modulates the self-renewal and therapeutic resistance of BCSCs. Small molecules, antibodies, and chimeric antigen receptor (CAR)-T cells targeting BCSCs have been developed, and their applications in combination with conventional therapies are undergoing clinical trials. In this review, we focus on the features of BCSCs, emphasize the major factors and tumor environment that regulate the stemness of BCSCs, and discuss potential BCSC-targeting therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Lily Boo, Huynh Ky, Dilan Amila Satharasinghe, Sheau Wei Tan, Soon Keng Cheong, Hsien Da Huang, Kuan Chun Lan, Men Yee Chiew, Han Kiat Ong
Summary: Breast cancer is the most frequently diagnosed cancer in women globally, and TME and MSCs play crucial roles in inducing dormancy of breast cancer cells, with exosomal miRNAs potentially serving as important therapeutic targets.
Article
Oncology
Utsav Sharma, Kelsie Medina-Saenz, Philip C. Miller, Benjamin Troness, Angela Spartz, Ana Sandoval-Leon, Deanna N. Parke, Tiffany N. Seagroves, Marc E. Lippman, Dorraya El-Ashry
Summary: The study revealed that the clustering of circulating CAFs and CTCs occurs early in BC progression and is present in all clinical stages of BC. Heterotypic cCAFs-CTC clusters have a higher metastatic potential compared to homotypic CTC clusters. The adhesion and stemness marker CD44 plays a significant role in the heterotypic clustering of cCAFs and BC cells, enhancing their metastatic potential. These findings highlight the impact of circulating cell clusters on BC metastasis.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Youssef Slama, Franck Ah-Pine, Mohamed Khettab, Angelique Arcambal, Mickael Begue, Fabien Dutheil, Philippe Gasque
Summary: Mesenchymal stem/stromal cells (MSCs) play a dual role in cancer pathophysiology by interacting with the tumor microenvironment and influencing tumor cells. They can promote tumor progression through various mechanisms while also exhibiting therapeutic effects such as anti-tumor and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Statistics & Probability
Ruiyu Xu, Jianguo Wu, Xiaowei Yue, Yongxiang Li
Summary: This article proposes an online structural change-point detection method for high-dimensional streaming data through dynamic sparse subspace learning and an efficient Pruned Exact Linear Time algorithm. The effectiveness of the method is demonstrated through simulation studies and a real case study.
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Environmental Sciences
Guangmei Wu, Guitao Shi, Chuanjin Li, Ye Hu, Hongmei Ma, Zhenlou Chen
Summary: During the 2015-2016 Chinese Antarctic Research Expedition, a study was conducted on Particulate-bound mercury (PBM) in the boundary layer. The study found a significant latitudinal gradient in PBM, with higher levels over the Northern Hemisphere influenced by both continental and oceanic sources. Over the Southern Ocean, PBM levels were extremely low, while elevated PBM was observed across the Antarctic Ice Sheet, particularly at Dome A. The study also revealed the role of inland Antarctic snow in influencing atmospheric PBM concentrations over the Antarctic coastal seas.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Alejandro Gallegos, Jianzhong Wu
Summary: In this work, a hierarchical method that incorporates liquid-state theories with the site-binding model is proposed to quantify the charging behavior of weak polyelectrolytes over a broad range of solution conditions.
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
