Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells

Nucleotide metabolism, oncogene-induced senescence and cancer

(2015) Katherine M. Aird et al.   CANCER LETTERS

Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?

(2014) Anthony J. Mutsaers et al.   BONE

RB Maintains Quiescence and Prevents Premature Senescence through Upregulation of DNMT1 in Mesenchymal Stromal Cells

(2014) Shih-Pei Lin et al.   Stem Cell Reports

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

(2013) Anthony J. Mutsaers et al.   BONE

Chemotherapy for osteosarcoma – Where does it come from? What is it? Where is it going?

(2013) Norio Yamamoto et al.   EXPERT OPINION ON PHARMACOTHERAPY

Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers

(2013) Markku Miettinen   HISTOPATHOLOGY

CD99 Drives Terminal Differentiation of Osteosarcoma Cells by Acting as a Spatial Regulator of ERK 1/2

(2013) Marika Sciandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation

(2013) Rene Rodriguez et al.   STEM CELLS

A novel p16INK4Amutation associated with esophageal squamous cell carcinoma in a high risk population

(2012) Meenu Asaas Qureshi et al.   BIOMARKERS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Efficient expansion of mesenchymal stem cells from mouse bone marrow under hypoxic conditions

(2012) Tu-Lai Yew et al.   Journal of Tissue Engineering and Regenerative Medicine

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development

(2012) R Rubio et al.   ONCOGENE

H3K9me-Enhanced DNA Hypermethylation of the p16INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells

(2012) Yong Zheng et al.   STEM CELLS AND DEVELOPMENT

Docosahexaenoic Acid Promotes Dopaminergic Differentiation in Induced Pluripotent Stem Cells and Inhibits Teratoma Formation in Rats with Parkinson-Like Pathology

(2011) Yuh-Lih Chang et al.   CELL TRANSPLANTATION

Primary giant-cell-rich osteosarcoma of the urinary bladder: usefulness of osteocalcin and osteonectin immunohistochemical staining and literature review

(2011) Kyu Yeoun Won et al.   PATHOLOGY

Concise Review: Mesenchymal Tumors: When Stem Cells Go Mad

(2011) Alexander B. Mohseny et al.   STEM CELLS

Serum alkaline phosphatase activity is not a marker for neoplastic transformation of esophageal nodules in canine spirocercosis

(2011) Varaidzo Mukorera et al.   VETERINARY CLINICAL PATHOLOGY

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

(2010) C.-C. Tsai et al.   BLOOD

Deficiency in p53 but not Retinoblastoma Induces the Transformation of Mesenchymal Stem Cells In vitro and Initiates Leiomyosarcoma In vivo

(2010) R. Rubio et al.   CANCER RESEARCH

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

(2010) A. Torsvik et al.   CANCER RESEARCH

Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma

(2010) J. Smida et al.   CLINICAL CANCER RESEARCH

Mesenchymal stem cells enhance growth and metastasis of colon cancer

(2010) Kei Shinagawa et al.   INTERNATIONAL JOURNAL OF CANCER

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis

(2010) T Shimizu et al.   ONCOGENE

Osteo-transcriptomics of human mesenchymal stem cells: Accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis

(2009) Ester Piek et al.   BONE

Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation

(2009) Gro Vatne Røsland et al.   CANCER RESEARCH

De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton

(2009) A. Kumarasuriyar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss ofCdkn2

(2009) Alexander B Mohseny et al.   JOURNAL OF PATHOLOGY

High grade osteosarcoma of the extremities metastatic to the lung: Long-term results in 323 patients treated combining surgery and chemotherapy, 1985–2005

(2009) Antonio Briccoli et al.   SURGICAL ONCOLOGY-OXFORD

Deregulating EMT and Senescence: Double Impact by a Single Twist

(2008) Marjon A. Smit et al.   CANCER CELL

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

(2008) C. R. Walkley et al.   GENES & DEVELOPMENT