Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

(2016) S. Teracciano et al.   CHEMICAL COMMUNICATIONS

Correction: Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

(2016) S. Terracciano et al.   CHEMICAL COMMUNICATIONS

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach

(2016) Maria G. Chini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors

(2016) Katherine M. Byrd et al.   CHEMISTRY-A EUROPEAN JOURNAL

Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90

(2016) Alexandra Rehn et al.   JOURNAL OF MOLECULAR BIOLOGY

In silico identification and computational analysis of the nucleotide binding site in the C-terminal domain of Hsp90

(2016) Samir S. Roy et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

New dihydropyrimidin-2(1H)-one based Hsp90 C-terminal inhibitors

(2016) S. Terracciano et al.   RSC Advances

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands

(2016) Gerolamo Vettoretti et al.   Scientific Reports

Identification and mechanism of action analysis of the new PARP-1 inhibitor 2″-hydroxygenkwanol A

(2015) Fabrizio Dal Piaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

(2015) Maria Strocchia et al.   CHEMICAL COMMUNICATIONS

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

(2015) Y. Wang et al.   CHEMICAL COMMUNICATIONS

Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

(2015) Tony Christopeit et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

(2015) Y. Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hsp90 Activity Modulation by Plant Secondary Metabolites

(2015) Fabrizio Piaz et al.   PLANTA MEDICA

Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

(2014) Bhaskar Reddy Kusuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alternative approaches to Hsp90 modulation for the treatment of cancer

(2014) Jessica A Hall et al.   Future Medicinal Chemistry

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

(2014) XIAOXIA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exploiting Conformational Dynamics in Drug Discovery: Design of C-Terminal Inhibitors of Hsp90 with Improved Activities

(2014) Elisabetta Moroni et al.   Journal of Chemical Information and Modeling

Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

(2014) Rohit Bhat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective targeting of the stress chaperome as a therapeutic strategy

(2014) Tony Taldone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design, Synthesis, and Biological Evaluation of Ring-Constrained Novobiocin Analogues as Hsp90 C-Terminal Inhibitors

(2014) Gaurav Garg et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors

(2013) G.M. Kamal B. Gunaherath et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors

(2013) Stefania Terracciano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Chemical–Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors

(2013) Fabrizio Dal Piaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the Plant Compound Geraniin as a Novel Hsp90 Inhibitor

(2013) Antonio Vassallo et al.   PLoS One

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

(2013) Katerina Sidera et al.   Recent Patents on Anti-Cancer Drug Discovery

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development

(2012) Shiro Soga et al.   CURRENT PHARMACEUTICAL DESIGN

Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90

(2012) Fabrizio Dal Piaz et al.   PLoS One

Extracellular HSP90: Conquering the cell surface

(2011) Katerina Sidera et al.   CELL CYCLE

The Hexameric Structures of Human Heat Shock Protein 90

(2011) Cheng-Chung Lee et al.   PLoS One

A systematic protocol for the characterization of Hsp90 modulators

(2010) Robert L. Matts et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

17 AAG for HSP90 Inhibition in Cancer – From Bench to Bedside

(2009) Saad Usmani et al.   CURRENT MOLECULAR MEDICINE