Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors

(2016) Katherine M. Byrd et al.   CHEMISTRY-A EUROPEAN JOURNAL

New dihydropyrimidin-2(1H)-one based Hsp90 C-terminal inhibitors

(2016) S. Terracciano et al.   RSC Advances

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

(2015) Maria Strocchia et al.   CHEMICAL COMMUNICATIONS

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

(2015) Y. Wang et al.   CHEMICAL COMMUNICATIONS

9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain

(2015) Sarah Picaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

(2015) Y. Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hsp90 Activity Modulation by Plant Secondary Metabolites

(2015) Fabrizio Piaz et al.   PLANTA MEDICA

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

(2015) Stefania Terracciano et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

(2014) Bhaskar Reddy Kusuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

(2014) Gianluigi Lauro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

(2014) XIAOXIA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?

(2014) Leticia Mayor-López et al.   Translational Oncology

Design, Synthesis, and Biological Evaluation of Ring-Constrained Novobiocin Analogues as Hsp90 C-Terminal Inhibitors

(2014) Gaurav Garg et al.   ACS Medicinal Chemistry Letters

Chemically Accessible Hsp90 Inhibitor That Does Not Induce a Heat Shock Response

(2014) Yen Chin Koay et al.   ACS Medicinal Chemistry Letters

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors

(2013) G.M. Kamal B. Gunaherath et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors

(2013) Stefania Terracciano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Chemical–Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors

(2013) Fabrizio Dal Piaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the Plant Compound Geraniin as a Novel Hsp90 Inhibitor

(2013) Antonio Vassallo et al.   PLoS One

The network interaction of the human cytosolic 90kDa heat shock protein Hsp90: A target for cancer therapeutics

(2012) Viviane C.H. da Silva et al.   Journal of Proteomics

The Hexameric Structures of Human Heat Shock Protein 90

(2011) Cheng-Chung Lee et al.   PLoS One

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

17 AAG for HSP90 Inhibition in Cancer – From Bench to Bedside

(2009) Saad Usmani et al.   CURRENT MOLECULAR MEDICINE

The Liebeskind-Srogl CC Cross-Coupling Reaction

(2008) Hana Prokopcová et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION