Identification of the Plant Compound Geraniin as a Novel Hsp90 Inhibitor

Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors

(2013) M. W. Saif et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo

(2012) Yajun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

A chemical proteomics approach reveals Hsp27 as a target for proapoptotic clerodane diterpenes

(2012) Laura Faiella et al.   Molecular BioSystems

Structural characterization of tetranortriterpenes from Pseudrocedrela kotschyi and Trichilia emetica and study of their activity towards the chaperone Hsp90

(2012) Fabrizio Dal Piaz et al.   PHYTOCHEMISTRY

Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90

(2012) Fabrizio Dal Piaz et al.   PLoS One

Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy

(2011) R. E. Wang   CURRENT MEDICINAL CHEMISTRY

Metabolites of the Ellagitannin Geraniin and Their Antioxidant Activities

(2011) Hideyuki Ito   PLANTA MEDICA

The Identification of a Novel Natural Activator of p300 Histone Acetyltranferase Provides New Insights into the Modulation Mechanism of this Enzyme

(2010) Fabrizio Dal Piaz et al.   CHEMBIOCHEM

Hsp90: A Drug Target?

(2010) Jeffrey M. Holzbeierlein et al.   Current Oncology Reports

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

(2009) Chiara Giommarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

(2009) Shivaani Kummar et al.   EUROPEAN JOURNAL OF CANCER

KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

(2009) S. N. Shelton et al.   MOLECULAR PHARMACOLOGY

(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor†

(2008) Zhengyu Yin et al.   BIOCHEMISTRY

A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer

(2008) E. I. Heath et al.   CLINICAL CANCER RESEARCH

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90

(2008) Christian N. Cunningham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships

(2008) Gary E. L. Brandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells

(2008) Jang-Chang Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH