Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors

Organelle-specific Hsp90 inhibitors

(2015) Young Ho Seo   ARCHIVES OF PHARMACAL RESEARCH

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

(2015) Maria Strocchia et al.   CHEMICAL COMMUNICATIONS

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

(2015) Y. Wang et al.   CHEMICAL COMMUNICATIONS

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands

(2015) Sara Sattin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors

(2015) Huiping Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

(2015) Y. Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

(2015) Xiaoping Song et al.   Oncotarget

Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix

(2014) Jason Gavenonis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines

(2014) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alternative approaches to Hsp90 modulation for the treatment of cancer

(2014) Jessica A Hall et al.   Future Medicinal Chemistry

Exploiting Conformational Dynamics in Drug Discovery: Design of C-Terminal Inhibitors of Hsp90 with Improved Activities

(2014) Elisabetta Moroni et al.   Journal of Chemical Information and Modeling

Triazole containing novobiocin and biphenyl amides as Hsp90 C-terminal inhibitors

(2014) Jinbo Zhao et al.   MedChemComm

Design, Synthesis, and Biological Evaluation of Ring-Constrained Novobiocin Analogues as Hsp90 C-Terminal Inhibitors

(2014) Gaurav Garg et al.   ACS Medicinal Chemistry Letters

Development of a High-Throughput Screening Cancer Cell-Based Luciferase Refolding Assay for Identifying Hsp90 Inhibitors

(2013) Takrima Sadikot et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Synthesis and Structure–Activity Relationships of EGCG Analogues, a Recently Identified Hsp90 Inhibitor

(2013) Anuj Khandelwal et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy

(2013) Jana Franke et al.   NATURAL PRODUCT REPORTS

Synthesis of Dibenzothiophene, Dibenzofuran and Carbazole Donor-Acceptor Chromophores

(2013) Mogens Nielsen et al.   SYNTHESIS-STUTTGART

Identification of a New Scaffold for Hsp90 C-Terminal Inhibition

(2013) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

(2012) Edward Richmond et al.   ORGANIC LETTERS

Heat Shock Protein 90 Inhibitors as Therapeutic Agents

(2012) Isabel Gomez-Monterrey et al.   Recent Patents on Anti-Cancer Drug Discovery

3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition

(2012) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

Elucidation of the Hsp90 C-Terminal Inhibitor Binding Site

(2011) Robert L. Matts et al.   ACS Chemical Biology

Phosphane-Free Green Protocol for Selective Nitro Reduction with an Iron-Based Catalyst

(2011) Upendra Sharma et al.   CHEMISTRY-A EUROPEAN JOURNAL

HSP90 inhibition: two-pronged exploitation of cancer dependencies

(2011) Jon Travers et al.   DRUG DISCOVERY TODAY

Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors

(2011) Bhaskar Reddy Kusuma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents

(2011) Huiping Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gambogic Acid, a Natural Product Inhibitor of Hsp90

(2011) Jason Davenport et al.   JOURNAL OF NATURAL PRODUCTS

Identification and initial SAR of silybin: An Hsp90 inhibitor

(2010) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity

(2010) Huiping Zhao et al.   ACS Medicinal Chemistry Letters

Modulation of Hsf1 activity by novobiocin and geldanamycin

(2009) Renaud Conde et al.   Biochemistry and Cell Biology

KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

(2009) S. N. Shelton et al.   MOLECULAR PHARMACOLOGY

(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor†

(2008) Zhengyu Yin et al.   BIOCHEMISTRY

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY