Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering
Authors
Keywords
-
Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-06-26
DOI
10.1038/s41598-018-28177-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene
- (2016) Zhenqiu Li et al. BIOCHEMISTRY
- The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering
- (2016) Jan-Ytzen van der Meer et al. CHEMBIOCHEM
- Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues
- (2016) Ingy I. Abdallah et al. JOURNAL OF NATURAL PRODUCTS
- Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives
- (2016) De-Yu Xie et al. PHYTOCHEMISTRY REVIEWS
- Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases
- (2016) Jan-Ytzen van der Meer et al. Nature Communications
- Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase
- (2014) Ruiqiong Li et al. BIOCHEMISTRY
- Evolutionary and Mechanistic Insights from the Reconstruction of α-Humulene Synthases from a Modern (+)-Germacrene A Synthase
- (2014) Veronica Gonzalez et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Measuring the activity of protein variants on a large scale using deep mutational scanning
- (2014) Douglas M Fowler et al. Nature Protocols
- Production and quantification of sesquiterpenes in Saccharomyces cerevisiae, including extraction, detection and quantification of terpene products and key related metabolites
- (2014) Sarah Rodriguez et al. Nature Protocols
- Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
- (2014) Chris J. Paddon et al. NATURE REVIEWS MICROBIOLOGY
- Semisynthetic Artemisinin, the Chemical Path to Industrial Production
- (2014) Joël Turconi et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Rational engineering of plasticity residues of sesquiterpene synthases fromArtemisia annua: product specificity and catalytic efficiency
- (2013) Jian-Xu Li et al. BIOCHEMICAL JOURNAL
- Malaria
- (2013) Nicholas J White et al. LANCET
- Terpenoid synthase structures: a so far incomplete view of complex catalysis
- (2012) Yang Gao et al. NATURAL PRODUCT REPORTS
- A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein
- (2012) Sriram Sokalingam et al. PLoS One
- Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
- (2012) P. J. Westfall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational design and selections for an engineered, thermostable terpene synthase
- (2011) Juan E. Diaz et al. PROTEIN SCIENCE
- Deep mutational scanning: assessing protein function on a massive scale
- (2011) Carlos L. Araya et al. TRENDS IN BIOTECHNOLOGY
- Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates
- (2010) Joseph P. Noel et al. ACS Chemical Biology
- Crystal Structure of (+)-δ-Cadinene Synthase fromGossypium arboreumand Evolutionary Divergence of Metal Binding Motifs for Catalysis
- (2009) Heather A. Gennadios et al. BIOCHEMISTRY
- Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis
- (2009) Dongming Ma et al. PLANT AND CELL PHYSIOLOGY
- Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
- (2008) Paul E O'Maille et al. Nature Chemical Biology
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started