Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo

Liver steatosis: The new epidemic of the Third Millennium. Benign liver state or silent killer?

(2017) Claudio Puoti et al.   European Journal of Internal Medicine

Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV

(2017) Minsoo Kang et al.   FASEB JOURNAL

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice

(2017) Joseph A. Cichocki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

Endocrine-disrupting chemicals and fatty liver disease

(2017) Charles E. Foulds et al.   Nature Reviews Endocrinology

Metabolism disrupting chemicals and metabolic disorders

(2017) Jerrold J. Heindel et al.   REPRODUCTIVE TOXICOLOGY

Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism

(2017) Kévin Hardonnière et al.   SEMINARS IN CANCER BIOLOGY

Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair

(2016) Q. Shi et al.   ARCHIVES OF TOXICOLOGY

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

(2016) Miroslav Šulc et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents

(2016) Normand Podechard et al.   JOURNAL OF APPLIED TOXICOLOGY

Association of environmental benzo[ a ]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case–control study

(2016) Meiping Tian et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

(2016) Anaïs Michaut et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α

(2016) Houssein Al-Attrache et al.   TOXICOLOGY LETTERS

Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

(2016) Carrie R Wong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish

(2016) Chunsheng Liu et al.   Scientific Reports

Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

(2015) Mazen Noureddin et al.   Clinics in Liver Disease

Zebrafish: An Important Tool for Liver Disease Research

(2015) Wolfram Goessling et al.   GASTROENTEROLOGY

High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs

(2015) Wencong Dai et al.   Nutrition & Metabolism

Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes

(2015) Frank Neuschäfer-Rube et al.   TOXICOLOGY

Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity

(2015) Marjo J. Den Broeder et al.   PPAR Research

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

(2015) Takeshi Inagaki   Frontiers in Endocrinology

Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons

(2014) Trevor M. Penning   CHEMICAL RESEARCH IN TOXICOLOGY

Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis

(2014) Yoshiki Kusunoki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cooperative interaction of benzo[a]pyrene and ethanol on plasma membrane remodeling is responsible for enhanced oxidative stress and cell death in primary rat hepatocytes

(2014) Aurore Collin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unknown

(2014) Takahiro Minato et al.   MOLECULAR MEDICINE

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

(2014) Marie Stiborová et al.   TOXICOLOGY

Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China

(2013) Yanhua Su et al.   ANNALS OF EPIDEMIOLOGY

The expanding role of fish models in understanding non-alcoholic fatty liver disease

(2013) Y. Asaoka et al.   Disease Models & Mechanisms

Reprint of “In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective”

(2013) Laura Ortiz et al.   TOXICOLOGY LETTERS

Molecular Interactions between NAFLD and Xenobiotic Metabolism

(2013) Adviti Naik et al.   Frontiers in Genetics

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

Toxicant-associated Steatohepatitis

(2012) Banrida Wahlang et al.   TOXICOLOGIC PATHOLOGY

Drug metabolism alterations in nonalcoholic fatty liver disease

(2011) Matthew D. Merrell et al.   DRUG METABOLISM REVIEWS

New Rapid HPLC Method for Separation and Determination of Benzo[A]Pyrene Hydroxyderivatives

(2011) ALENA BEDNÁRIKOVÁ et al.   POLYCYCLIC AROMATIC COMPOUNDS

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye

(2011) K. Pernelle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role

(2011) J. Aubert et al.   Clinics and Research in Hepatology and Gastroenterology

Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2010) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Metabolic syndrome and hepatocellular carcinoma

(2009) Abby B. Siegel et al.   CANCER

Toxicant-associated steatohepatitis in vinyl chloride workers

(2009) Matt Cave et al.   HEPATOLOGY

Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio)

(2009) Edward J. Flynn et al.   JOURNAL OF LIPID RESEARCH

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

(2008) Michael J. Passeri et al.   HEPATOLOGY

Quantification of benzo[a]pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers

(2007) Michael S. Neal et al.   REPRODUCTIVE TOXICOLOGY