Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

Uncarboxylated Osteocalcin Enhances Glucose Uptake Ex Vivo in Insulin-Stimulated Mouse Oxidative But Not Glycolytic Muscle

(2018) Xuzhu Lin et al.   CALCIFIED TISSUE INTERNATIONAL

Effect of vitamin K2 on type 2 diabetes mellitus: A review

(2018) Yan Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Phylloquinone intake, insulin sensitivity, and glycemic status in men and women

(2018) Makiko Yoshida et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circulating osteocalcin is unrelated to glucose homoeostasis in adults with type 1 diabetes

(2017) Bu B. Yeap et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women

(2017) Jessica Bonneau et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Gpr158 mediates osteocalcin’s regulation of cognition

(2017) Lori Khrimian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin

(2017) I. Levinger et al.   OSTEOPOROSIS INTERNATIONAL

Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth

(2017) Yoshikazu Hayashi et al.   Journal of Cancer

Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles

(2017) Xuzhu Lin et al.   Frontiers in Endocrinology

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

(2016) Paula Mera et al.   Cell Metabolism

Profile of diabetes in men aged 79-97 years: the Western Australian Health in Men Study

(2016) M. Henze et al.   DIABETIC MEDICINE

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

(2016) Laura J. Lambert et al.   Disease Models & Mechanisms

Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells

(2016) Min Pi et al.   ENDOCRINOLOGY

Autophagic dysfunction is improved by intermittent administration of osteocalcin in obese mice

(2016) B Zhou et al.   INTERNATIONAL JOURNAL OF OBESITY

Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats

(2016) Xuzhu Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

(2016) Paula Mera et al.   Molecular Metabolism

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

(2016) Patricia Rueda et al.   PLoS One

Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise

(2015) Gregory D. Cartee   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin

(2015) Shintaro Tsuka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone and muscle: Interactions beyond mechanical

(2015) Marco Brotto et al.   BONE

Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men

(2015) Beom-hee Choi et al.   CLINICAL ENDOCRINOLOGY

The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial

(2015) H Rasekhi et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Association of serum total osteocalcin with type 2 diabetes and intermediate metabolic phenotypes: systematic review and meta-analysis of observational evidence

(2015) Setor Kwadzo Kunutsor et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population–Based StudyNovelty and Significance

(2015) Edward Pivin et al.   HYPERTENSION

Association of Cardiometabolic Multimorbidity With Mortality

(2015) Emanuele Di Angelantonio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Higher Serum Undercarboxylated Osteocalcin and Other Bone Turnover Markers Are Associated With Reduced Diabetes Risk and Lower Estradiol Concentrations in Older Men

(2015) Bu B. Yeap et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bisphosphonates and Glucose Homeostasis: A Population-Based, Retrospective Cohort Study

(2015) Konstantinos A. Toulis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Proportion of Undercarboxylated Osteocalcin and Serum P1NP Predict Incidence of Myocardial Infarction in Older Men

(2015) Bu B. Yeap et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diabetes, Myocardial Infarction and Stroke Are Distinct and Duration-Dependent Predictors of Subsequent Cardiovascular Events and All-Cause Mortality in Older Men

(2015) Bu B. Yeap et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults

(2015) Veerle Dam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effect of Treatment With PTH on Undercarboxylated Osteocalcin and Energy Metabolism in Hypoparathyroidism

(2015) Torben Harsløf et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

(2015) I. Levinger et al.   OSTEOPOROSIS INTERNATIONAL

Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women

(2014) Itamar Levinger et al.   BONE

Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion

(2014) Akiko Mizokami et al.   BONE

Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein

(2014) Sophie Liabeuf et al.   Cardiovascular Diabetology

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

(2014) Cyrille B Confavreux et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Effect of Acute Exercise on Undercarboxylated Osteocalcin and Insulin Sensitivity in Obese Men

(2014) Itamar Levinger et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

(2014) R. Saucedo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Endocrine Crosstalk Between Muscle and Bone

(2014) Marco Brotto et al.   Current Osteoporosis Reports

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

(2013) C Clemmensen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions

(2013) Franck Oury et al.   CELL

Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism

(2013) Bo Zhou et al.   CELL CYCLE

Osteocalcin Promotes  -Cell Proliferation During Development and Adulthood Through Gprc6a

(2013) J. Wei et al.   DIABETES

Matrix Gla Protein Species and Risk of Cardiovascular Events in Type 2 Diabetic Patients

(2013) G. W. Dalmeijer et al.   DIABETES CARE

Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-Induced Obesity Through Nuclear Factor-κB Signaling Pathway

(2013) Bo Zhou et al.   ENDOCRINOLOGY

Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women

(2013) Noriko Koitaya et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Effects of antiresorptive therapies on glucose metabolism: Results from the FIT, HORIZON-PFT, and FREEDOM trials

(2013) Ann V Schwartz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study

(2013) Andrés Díaz-López et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Higher Serum Osteocalcin Is Associated With Lower Abdominal Aortic Calcification Progression and Longer 10-Year Survival in Elderly Men of the MINOS Cohort

(2013) Cyrille B. Confavreux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Associations of Total and Undercarboxylated Osteocalcin With Peripheral and Hepatic Insulin Sensitivity and β-Cell Function in Overweight Adults

(2013) Barbara A. Gower et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

(2013) Rong Yang et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Association of bone turnover markers with mortality in women referred to coronary angiography: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

(2013) E. Lerchbaum et al.   OSTEOPOROSIS INTERNATIONAL

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice

(2013) Akiko Mizokami et al.   PLoS One

Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania

(2013) Anke Hannemann et al.   BMC Endocrine Disorders

Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease

(2012) Núria Ibarrola-Jurado et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study

(2012) Mirjam M. Oosterwerff et al.   CLINICAL ENDOCRINOLOGY

Circulating Osteocalcin Level Is Not Associated With Incident Type 2 Diabetes in Middle-Aged Male Subjects: Mean 8.4-year retrospective follow-up study

(2012) Y.-C. Hwang et al.   DIABETES CARE

Diabetes in Older Adults

(2012) M. S. Kirkman et al.   DIABETES CARE

Multiligand Specificity and Wide Tissue Expression of GPRC6A Reveals New Endocrine Networks

(2012) Min Pi et al.   ENDOCRINOLOGY

Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism

(2012) Ali Movahed et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Osteocalcin: Skeletal and extra-skeletal effects

(2012) Anna Neve et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism

(2012) Tara C. Brennan-Speranza et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of bone turnover markers with mortality in men referred to coronary angiography

(2012) E. Lerchbaum et al.   OSTEOPOROSIS INTERNATIONAL

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

(2012) Katsuhito Mori et al.   Diabetology & Metabolic Syndrome

Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?

(2012) Caren M. Gundberg et al.   Advances in Nutrition

Total and undercarboxylated osteocalcin predict changes in insulin sensitivity and β cell function in elderly men at high cardiovascular risk

(2011) Mònica Bulló et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

(2011) Mathieu Ferron et al.   BONE

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

(2011) Marjo H. J. Knapen et al.   BRITISH JOURNAL OF NUTRITION

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men

(2011) Yuqian Bao et al.   CLINICAL ENDOCRINOLOGY

Vitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial

(2011) H. J. Choi et al.   DIABETES CARE

The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

(2011) P. Ducy   DIABETOLOGIA

Acute effects of plyometric jumping and intermittent running on serum bone markers in young males

(2011) Che-Fu Lin et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women

(2011) Suk Woo Lee et al.   GYNECOLOGICAL ENDOCRINOLOGY

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

(2011) Min Pi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

(2011) MELANIE S. HOOD et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey

(2011) Aihua Tan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study

(2011) B. B. Yeap et al.   OSTEOPOROSIS INTERNATIONAL

Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

(2011) M. Iki et al.   OSTEOPOROSIS INTERNATIONAL

Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

(2011) K. M. Thrailkill et al.   OSTEOPOROSIS INTERNATIONAL

Relation of Serum Osteocalcin Level to Risk of Coronary Heart Disease in Chinese Adults

(2010) Yifei Zhang et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of phylloquinone supplementation on glucose homeostasis in humans

(2010) Rajiv Kumar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

In vivo exercise followed by in vitro contraction additively elevates subsequent insulin-stimulated glucose transport by rat skeletal muscle

(2010) Katsuhiko Funai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Serum Osteocalcin Is Associated With Measures of Insulin Resistance, Adipokine Levels, and the Presence of Metabolic Syndrome

(2010) Umer Saleem et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An ELISA-based method to quantify osteocalcin carboxylation in mice

(2010) Mathieu Ferron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

(2010) J. W. J. Beulens et al.   DIABETES CARE

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

(2010) Bu B Yeap et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability

(2010) Håkan Westerblad et al.   EXPERIMENTAL CELL RESEARCH

Function of the Bone Protein Osteocalcin: Definitive Evidence

(2010) George Wolf   NUTRITION REVIEWS

The association between serum osteocalcin levels and metabolic syndrome in Koreans

(2010) S. J. Bae et al.   OSTEOPOROSIS INTERNATIONAL

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus

(2010) I. Kanazawa et al.   OSTEOPOROSIS INTERNATIONAL

The effect of acute exercise on undercarboxylated osteocalcin in obese men

(2010) I. Levinger et al.   OSTEOPOROSIS INTERNATIONAL

Bone Metabolism Markers in Sports Medicine

(2010) Giuseppe Banfi et al.   SPORTS MEDICINE

γ-Carboxylation of osteocalcin and insulin resistance in older men and women

(2009) M Kyla Shea et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects

(2009) You-Cheol Hwang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

(2009) Mi Zhou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adiponectin Is Associated with Changes in Bone Markers during Glycemic Control in Type 2 Diabetes Mellitus

(2009) Ippei Kanazawa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

(2009) Tatsuya Yoshizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

(2009) Marie-Therese Rached et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship between osteocalcin and glucose metabolism in postmenopausal women

(2008) Jee-Aee Im et al.   CLINICA CHIMICA ACTA

Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women

(2008) M. Yoshida et al.   DIABETES CARE

Increased Bone Resorption Is Associated With Higher Mortality in Community-Dwelling Men ≥50 Years of Age: The MINOS Study

(2008) Pawel Szulc et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men

(2008) Jenny M Kindblom et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association between Serum Osteocalcin and Markers of Metabolic Phenotype

(2008) Anastassios G. Pittas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

(2008) Ippei Kanazawa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training

(2008) Jose Manuel Fernández-Real et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

(2008) Mathieu Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism and cell biology of vitamin K

(2008) Paul Newman et al.   THROMBOSIS AND HAEMOSTASIS