The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

(2013) Christoffer Clemmensen et al.   JOURNAL OF ENDOCRINOLOGY

Enhanced voluntary wheel running in GPRC6A receptor knockout mice

(2013) Christoffer Clemmensen et al.   PHYSIOLOGY & BEHAVIOR

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

(2012) Sanela Smajilovic et al.   AMINO ACIDS

Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells

(2012) Erik C. Dreaden et al.   BIOCONJUGATE CHEMISTRY

Novel Strategies in Drug Discovery of the Calcium-Sensing Receptor Based on Biased Signaling

(2012) Alex Rojas Bie Thomsen et al.   CURRENT DRUG TARGETS

GPRC6A Mediates the Effects ofl-Arginine on Insulin Secretion in Mouse Pancreatic Islets

(2012) Min Pi et al.   ENDOCRINOLOGY

The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells

(2012) Manami Oya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes

(2012) Cesare Orlandi et al.   JOURNAL OF CELL BIOLOGY

The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine

(2012) Oliver J. Mace et al.   JOURNAL OF PHYSIOLOGY-LONDON

A new era of GPCR structural and chemical biology

(2012) Sébastien Granier et al.   Nature Chemical Biology

Replication and Fine Mapping for Association of the C2orf43, FOXP4, GPRC6A and RFX6 Genes with Prostate Cancer in the Chinese Population

(2012) Qing-Zhi Long et al.   PLoS One

Nutrient sensing in the gut: new roads to therapeutics?

(2012) Sara Janssen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Receptors Responsive to Protein Breakdown Products in G-Cells and D-Cells of Mouse, Swine and Human

(2012) Désirée Christine Haid et al.   Frontiers in Physiology

l-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

(2011) Christoffer Clemmensen et al.   AMINO ACIDS

Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case–control study in the ChinaPCa consortium

(2011) Meilin Wang et al.   CARCINOGENESIS

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Chemogenomic Discovery of Allosteric Antagonists at the GPRC6A Receptor

(2011) David E. Gloriam et al.   CHEMISTRY & BIOLOGY

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

(2011) Min Pi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nutrient sensing receptors in gastric endocrine cells

(2011) Désirée Haid et al.   JOURNAL OF MOLECULAR HISTOLOGY

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

(2011) Mahesh M. Karnani et al.   NEURON

GPRC6A regulates prostate cancer progression

(2011) Min Pi et al.   PROSTATE

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

GPRC6A Mediates the Non-genomic Effects of Steroids

(2010) Min Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional expression of the extracellular-Ca 2+ -sensing receptor in mouse taste cells

(2010) Marina F. Bystrova et al.   JOURNAL OF CELL SCIENCE

Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

(2010) Ryo Takata et al.   NATURE GENETICS

The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

(2010) Philippe Rondard et al.   NEUROPHARMACOLOGY

Molecular basis for amino acid sensing by family C G-protein-coupled receptors

(2009) P Wellendorph et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

(2009) Helene Faure et al.   CELL CALCIUM

Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients

(2009) P. Wellendorph et al.   MOLECULAR PHARMACOLOGY

Evidence for the presence of GPRC6A receptors in rat mesenteric arteries

(2008) Erika Harno et al.   CELL CALCIUM

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

(2008) Petrine Wellendorph et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

(2008) Min Pi et al.   PLoS One