Article
Materials Science, Multidisciplinary
Huapan Fang, Qian Chen
Summary: A proton transistornanodetergent (pTNT) has been developed to convert subtle pH perturbation signals into remarkable transition signals of membranolytic activity for precise cancer treatment.
Review
Pharmacology & Pharmacy
S. M. Shatil Shahriar, Syed Muntazir Andrabi, Farhana Islam, Jeong Man An, Samantha J. Schindler, Mitchell P. Matis, Dong Yun Lee, Yong-kyu Lee
Summary: Cancer is the second leading cause of death after cardiovascular disease. However, it is difficult to cure end-stage cancer patients and chemotherapy has adverse effects. Three-dimensional scaffold-based nano-delivery systems can selectively deliver chemotherapeutics to target sites, improving local cancer therapy.
Article
Chemistry, Medicinal
Mingyuan Li, Shuangshuang Li, Yuan Li, Xinyi Li, Guang Yang, Meng Li, Yanbo Xie, Wen Su, Jianru Wu, Lin Jia, Shiqin Li, Wenlin Ma, Haiming Li, Na Guo, Peng Yu
Summary: In this study, paclitaxel, crizotinib, and Bcl-xL siRNA were co-loaded in cationic liposomes, which showed promising results as a delivery system for breast cancer treatment, with improved targeting efficiency and reduced side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Quanquan Xie, Jiayi Tang, Shengze Guo, Qi Zhao, Shengliang Li
Summary: Phototherapy is a targeted and less invasive treatment method compared to surgery, chemotherapy, and radiotherapy. The choice of appropriate preparation strategies for nanoparticles is challenging but significant. This review summarizes recent progress in organic nanoparticle preparation strategies, focusing on principles, methods, advantages, and examples of cancer phototherapeutics. It also proposes future trends and outlook.
Article
Pharmacology & Pharmacy
Wenzhen Du, Lijing Zhang, Xiaodan Li, Guixia Ling, Peng Zhang
Summary: With the rapid growth of nanomedicine research, subcellular-delivery nanosystems (SDNSs) have become a research focus in the field of cancer treatment. Nuclear-targeted SDNSs, which deliver therapeutic agents and assist various treatment methods, may have the potential for precise cancer treatment. This review summarizes the latest progress of nuclear-targeted SDNSs for cancer treatment, discusses the possible mechanisms of SDNSs entering the nucleus, its applications in cancer treatment, and highlights the promising future of SDNSs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Xin-Hui Cao, Ming-Xing Liang, Yang Wu, Kai Yang, Jin-Hai Tang, Wei Zhang
Summary: EVs serve as nano-carriers for antitumor drugs, gene drugs, and other nanomaterials with anticancer capabilities. Improving the preparation methods and drug loading capacity of EVs can enhance their cancer-targeting efficiency. EV-based drug delivery holds promise for precise cancer treatment in the future.
Review
Chemistry, Multidisciplinary
Abraham B. Alemayehu, Kolle E. Thomas, Rune F. Einrem, Abhik Ghosh
Summary: Porphyrin chemistry is a field that continues to reveal new molecular mechanisms and properties, with corroles and 5d metallocorroles being particularly interesting areas of study. Different approaches, including metal-alkyl, low-valent organometallic, and metal acetate, have been used to synthesize 5d metallocorroles. These compounds show remarkable stability and potential applications in cancer phototherapeutics, making them promising building blocks for therapeutic and diagnostic agents.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Miaojuan Qiu, Junzong Chen, Xiuyu Huang, Binbin Li, Shiqiang Zhang, Peng Liu, Qiang Wang, Zhi Rong Qian, Yihang Pan, Yu Chen, Jing Zhao
Summary: This study successfully achieved synergistic treatment for intraperitoneally disseminated ovarian cancer by using RGD-modified amorphous calcium phosphate loaded with doxorubicin. The engineered calcium-involved nanomedicine augmented the therapeutic effect of doxorubicin and showed favorable anti-tumor effects in an experimental model.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Baoli Yin, Qiaoqiao Qin, Zhe Li, Youjuan Wang, Xinlin Liu, Yongchao Liu, Shuangyan Huan, Xiaobing Zhang, Guosheng Song
Summary: The study developed a novel NIR-II molecule with improved activation efficiency and targeted therapy for tongue cancer through rational design of the molecular structure.
Review
Biochemistry & Molecular Biology
Shuya Yano, Hiroshi Tazawa, Hiroyuki Kishimoto, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M. Hoffman
Summary: Oncolytic virotherapy using telomerase-specific replication-competent adenoviruses and fluorescence imaging technology enables precise targeting of tumors, especially cancer stem cells resistant to chemotherapy. The combination of oncolytic adenovirus therapy and fluorescence imaging techniques holds significant clinical potential for accurate tumor resection, targeted photosensitization, and optimized timing of therapeutic agent administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sulltana Jahan, Md. Emranul Karim, Ezharul Hoque Chowdhury
Summary: The challenges of traditional chemotherapy, such as low bioavailability and adverse side effects, can be overcome by utilizing nanoparticles for drug delivery, which can enhance therapeutic efficacy and reduce toxicity. Targeted nanoparticles can be designed to deliver drugs to specific receptors on tumor cells, improving treatment outcomes and minimizing off-target effects.
Article
Chemistry, Multidisciplinary
Seungyeop Choi, Yongmin Jeon, Jeong Hyun Kwon, Chunhwa Ihm, Seung Yeon Kim, Kyung Cheol Choi
Summary: A textile-based wearable OLED platform for neonatal jaundice phototherapy is proposed in this study. The platform is soft and flexible, conforming to the curvature of the human body, and shows suitable performance for jaundice treatment, even at low voltage.
Article
Chemistry, Multidisciplinary
Huimin Zhang, Weina Tang, Qi Gong, Xinyi Yang, Yunqiang Sun, Zhichao Dai, Zunfu Hu, Xiuwen Zheng
Summary: This study utilized a dual gate-controlled intelligent nanoreactor to achieve photothermal therapy-enhanced disulfiram chemotherapy and FePtMn-based chemodynamic therapy, improving the efficiency of tumor treatment.
Article
Engineering, Biomedical
Jialun Duan, Chunjie Bao, Ying Xie, Haitao Guo, Yixuan Liu, Jianwei Li, Rui Liu, Peishan Li, Jing Bai, Yan Yan, Limin Mu, Xueqi Li, Guiling Wang, Wanliang Lu
Summary: This study developed a targeted core-shell nano-particles carrying dual plasmids for precise gene insertion to treat metastatic breast cancer, and found the associated inhibitory mechanism.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Wei He, Guanyu Ma, Quanli Shen, Zhenghua Tang
Summary: This review summarizes the applications of gold nanostructures in cancer diagnosis and treatment, including spherical gold nanoparticles, gold nanorods, and atomically precise gold nanoclusters. The challenges and future perspectives in this field are discussed, which are of great significance in understanding the potential of gold nanomaterials in cancer treatment.
Letter
Oncology
Sena Kim, Kidist Ashami, Sora Lim, Karl Staser, Kiran Vij, Srikanth Santhanam, Julie Ritchey, Sarah Peterson, Feng Gao, Matthew A. Ciorba, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Article
Radiology, Nuclear Medicine & Medical Imaging
Indulekha Singaravelu, Henry Spitz, Mary Mahoney, Zhongyun Dong, Nalinikanth Kotagiri
Summary: This study found that the combination of the antiandrogen drug bicalutamide with F-18-FDG can enhance the treatment of triple-negative breast cancer (TNBC), and this effect was confirmed through in vitro and in vivo experiments in cell and mouse tumor models.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Engineering, Biomedical
Shindu C. Thomas, Tushar Madaan, Nitin S. Kamble, Nabil A. Siddiqui, Giovanni M. Pauletti, Nalinikanth Kotagiri
Summary: Desmoplastic solid tumors are characterized by the rapid accumulation of extracellular matrix macromolecules, but a hypervesiculating E. coli Nissle based tumor-targeting system has been developed to disrupt the tumor stroma using fusion peptides. By combining this system with immune checkpoint antibodies and tyrosine kinase inhibitors, improved immunotherapy outcomes and enhanced efficacy of biological signaling inhibitors can be achieved. The engineered bacterial vector shows biocompatibility and has the potential to be a reliable live biotherapeutic candidate.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Oncology
Julie O'Neal, Julie K. Ritchey, Matthew L. Cooper, Jessica Niswonger, L. Sofia Gonzalez, Emily Street, Michael P. Rettig, Susan W. Gladney, Leah Gehrs, Ramzi Abboud, Julie L. Prior, Gabriel J. Haas, Reyka G. Jayasinghe, Li Ding, Armin Ghobadi, Ravi Vij, John F. DiPersio
Summary: The study suggests that CAR-T therapy targeting CS1 could be an effective treatment for multiple myeloma patients, and deleting CS1 in clinical production did not provide additional benefits.
Article
Multidisciplinary Sciences
Miriam Y. Kim, Reyka Jayasinghe, Jessica M. Devenport, Julie K. Ritchey, Michael P. Rettig, Julie O'Neal, Karl W. Staser, Krista M. Kennerly, Alun J. Carter, Feng Gao, Byung Ha Lee, Matthew L. Cooper, John F. DiPersio
Summary: A study has found that a long-acting form of recombinant human interleukin-7 can enhance the efficacy of chimeric antigen receptor (CAR) T cell therapy, promoting cell proliferation, persistence, and cytotoxicity, resulting in long-term tumor-free survival.
NATURE COMMUNICATIONS
(2022)
Letter
Hematology
Armin Ghobadi, Jack H. Landmann, Alun Carter, Matthew L. Cooper, Mehmet Emrah Selli, Jufang Chang, Matthew Baker, Christopher A. Miller, Francesca Ferraro, David Y. Chen, Amanda M. Smith, Taylor A. LaValle, Eric J. Duncavage, Justin Chou, Victor Tam, Joseph M. Benoun, Jenny Nater, Nathalie Scholler, Francesca Milletti, Remus Vezan, Adrian Bot, John M. Rossi, Nathan Singh
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Article
Cardiac & Cardiovascular Systems
Melissa L. Bates, Anastasiia Vasileva, Laura D. M. Flores, Yana Pryakhina, Michelle Buckman, Michael H. Tomasson, Lara R. DeRuisseau
Summary: This meta-analysis examines potential sex differences in cardiovascular diseases in patients with Down syndrome. The findings suggest that female patients with Down syndrome are at higher risk of hypertension, ischemic heart disease, and cerebrovascular disease, while males with Down syndrome have a higher risk of congenital heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Oncology
Lijun Yao, Julia T. Wang, Reyka G. Jayasinghe, Julie O'Neal, Chia-Feng Tsai, Michael P. Rettig, Yizhe Song, Ruiyang Liu, Yanyan Zhao, Omar M. Ibrahim, Mark A. Fiala, Julie M. Fortier, Siqi Chen, Leah Gehrs, Fernanda Martins Rodrigues, Michael C. Wendl, Daniel Kohnen, Andrew Shinkle, Song Cao, Steven M. Foltz, Daniel Cui Zhou, Erik Storrs, Matthew A. Wyczalkowski, Smrithi Mani, Scott R. Goldsmith, Ying Zhu, Mark Hamilton, Tao Liu, Feng Chen, Ravi Vij, Li Ding, John F. DiPersio
Summary: This study utilizes single-cell transcriptomic profiling to identify potential therapeutic targets for multiple myeloma. The analysis identified 38 marker genes encoding cell-surface and intracellular proteins, including 11 previously uncharacterized targets. The findings provide valuable insights for the development of targeted antitumor therapy.
Article
Physiology
Zishan Zhang, Hardik Kalra, Matthew C. Delzell, Charles R. Jedlicka, Mikhail Vasilyev, Anastasiia Vasileva, Michael H. Tomasson, Melissa L. Bates
Summary: The purpose of this paper is to demonstrate potential sources of variability in chamber exposures used to evaluate intermittent hypoxia. Sex-dependent differences were found in the commonly used C57BL6/J mouse model. The time delay and cycle number impact the stability of oxygen concentration. The presence of animals in the chamber also affects the variables. Reporting and verifying target oxygen concentration, cycling frequency, and arterial oxygen concentration is important when comparing different animal models and chamber configurations.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Keith Stockerl-Goldstein, Sarah M. Larson, Illes Arpad, Giulio A. Milone, Massimo Martino, Patrick Stiff, Douglas Sborov, Denise Pereira, Ivana Micallef, Gemma Moreno-Jimenez, Gabor Mikala, Maria Liz Paciello Coronel, Udo Holtick, John Hiemenz, Muzaffar H. Qazilbash, Nancy Hardy, Tahir Latif, Irene Garcia-Cadenas, Abi Vainstein-Haras, Ella Sorani, Irit Gliko-Kabir, Inbal Goldstein, Debby Ickowicz, Liron Shemesh-Darvish, Shaul Kadosh, Feng Gao, Mark A. Schroeder, Ravi Vij, John F. DiPersio
Summary: Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). Motixafortide combined with G-CSF significantly improves the collection of CD34(+) hematopoietic stem cells compared to G-CSF alone. Motixafortide + G-CSF demonstrates superior efficacy in ASCT.
Article
Engineering, Biomedical
Nabil A. Siddiqui, Alec J. Ventrola, Alexandra R. Hartman, Tohonne Konare, Nitin S. Kamble, Shindu C. Thomas, Tushar Madaan, Jordan Kharofa, Mathieu G. Sertorio, Nalinikanth Kotagiri
Summary: Targeted radionuclide therapy (TRT) is a promising treatment modality for solid cancers. In this study, tumor-colonizing Escherichia coli Nissle 1917 (EcN) is used to deliver a bacteria-specific radiopharmaceutical to solid tumors. The genetically modified bacteria selectively concentrate copper radioisotopes and deliver cytotoxic doses to cancer cells, resulting in significant attenuation of tumor growth and extended survival.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Hematology
Julie O'Neal, Matthew L. Cooper, Julie K. Ritchey, Susan Gladney, Jessica Niswonger, Sofia Gonzalez, L. Sofia Gonzalez, Emily Street, Gabriel J. Haas, Alun Carter, Parmeshwar N. Amayta, Feng Gao, Byung Ha Lee, Donghoon Choi, Melissa Berrien-Elliott, Alice Zhou, Todd A. Fehniger, Mike P. Rettig, John F. Dipersio
Summary: BCMA CAR-iNKTs have shown significant anti-myeloma activity in a mouse model, and the efficacy is further enhanced by rhIL-7-hyFc, suggesting that they may be a safer and more effective alternative to BCMA CAR-Ts.
Article
Hematology
Ziheng Xu, Jaebok Choi, Matthew Cooper, Jeffrey King, Mark A. Fiala, Jingxia Liu, Iskra Pusic, Rizwan Romee, Amanda Cashen, Meagan A. Jacoby, Keith Stockerl-Goldstein, Camille Abboud, Ravi Vij, Geoffrey Uy, Peter Westervelt, Matthew J. Walter, John F. Dipersio, Mark A. Schroeder
Summary: This study aimed to determine the maximum tolerated dose (MTD) of azacitidine (AZA) and its impact on graft-versus-host disease (GVHD) and chronic GVHD (cGVHD) after hematopoietic cell transplantation (HCT). The results showed that the efficacy of AZA in preventing GVHD was limited, but it may have a beneficial effect in preventing disease relapse.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
