Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors

Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors

(2021) Chung-Jen Chiang et al.   Scientific Reports

Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteria

(2021) Nabil A. Siddiqui et al.   JCI Insight

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

Developing a new class of engineered live bacterial therapeutics to treat human diseases

(2020) Mark R. Charbonneau et al.   Nature Communications

Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

(2020) Ioannis K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor

(2020) Cuixia Yang et al.   Cell Death & Disease

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

(2019) Caroline B. Kurtz et al.   Science Translational Medicine

Structure and mechanism of the Red recombination system of bacteriophage λ

(2019) Brian J. Caldwell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

(2019) John D. Martin et al.   Annual Review of Physiology

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis

(2019) HUDA I. ATIYA et al.   ANTICANCER RESEARCH

Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism

(2019) Alexandra Crowe et al.   PHARMACEUTICAL RESEARCH

Remodeling the Tumor Microenvironment Sensitizes Breast Tumors to Anti- Programmed Death-Ligand 1 Immunotherapy

(2019) Renee Clift et al.   CANCER RESEARCH

Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers

(2019) Tze-Sian Chan et al.   Frontiers in Oncology

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Hyaluronidase-Expressing Salmonella Effectively Targets Tumor-Associated Hyaluronic Acid in Pancreatic Ductal Adenocarcinoma

(2019) Nancy D Ebelt et al.   MOLECULAR CANCER THERAPEUTICS

Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery

(2019) Molly A. Taylor et al.   Journal for ImmunoTherapy of Cancer

Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer

(2019) Jonas Steenbrugge et al.   Frontiers in Immunology

The Extracellular, Cellular, and Nuclear Stiffness, a Trinity in the Cancer Resistome—A Review

(2019) Sara Sofia Deville et al.   Frontiers in Oncology

Bioengineered Escherichia coli Nissle 1917 for tumour‐targeting therapy

(2019) Xiaoli Yu et al.   Microbial Biotechnology

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

(2018) Vincent M Isabella et al.   NATURE BIOTECHNOLOGY

Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity

(2018) Tanel Ozdemir et al.   Cell Systems

Types and origins of bacterial membrane vesicles

(2018) Masanori Toyofuku et al.   NATURE REVIEWS MICROBIOLOGY

Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy

(2018) Ruijuan Li et al.   RESEARCH IN MICROBIOLOGY

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

(2018) Chloé Grasselly et al.   Frontiers in Immunology

Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance

(2018) Zoe Price et al.   Cancers

Copper import in Escherichia coli by the yersiniabactin metallophore system

(2017) Eun-Ik Koh et al.   Nature Chemical Biology

Construction and Characterization of Broad-Spectrum Promoters for Synthetic Biology

(2017) Sen Yang et al.   ACS Synthetic Biology

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

(2016) Andriy Marusyk et al.   CANCER RESEARCH

Identification and characterization of a bacterial hyaluronidase and its production in recombinant form

(2016) Luciano Messina et al.   FEBS LETTERS

Constitutive expression of recombinant human hyaluronidase PH20 by Pichia pastoris

(2016) Kuan-Jung Chen et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice

(2016) C. Garrett Rappazzo et al.   VACCINE

Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain

(2016) Xu Wan et al.   Oncotarget

Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells

(2016) Chun-Yu Liu et al.   Oncotarget

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

(2016) Ken Takai et al.   Oncotarget

Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection

(2016) Weiwei Huang et al.   Scientific Reports

Comparative analysis of the uropathogenic Escherichia coli surface proteome by tandem mass-spectrometry of artificially induced outer membrane vesicles

(2015) Daniël J. Wurpel et al.   Journal of Proteomics

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Programmable probiotics for detection of cancer in urine

(2015) Tal Danino et al.   Science Translational Medicine

Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB

(2015) Kamila Müller-Edenborn et al.   Oncotarget

NlpI-mediated modulation of outer membrane vesicle production through peptidoglycan dynamics inEscherichia coli

(2015) Carmen Schwechheimer et al.   MicrobiologyOpen

Hyaluronan, Inflammation, and Breast Cancer Progression

(2015) Kathryn L. Schwertfeger et al.   Frontiers in Immunology

CTAB turbidimetric method for assaying hyaluronic acid in complex environments and under cross-linked form

(2014) Nadia Oueslati et al.   CARBOHYDRATE POLYMERS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase

(2013) O Shpilberg et al.   BRITISH JOURNAL OF CANCER

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors

(2010) Andre Kaeßler et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli –mediated Cytolytic Therapy and Radiotherapy

(2010) Sheng-Nan Jiang et al.   MOLECULAR THERAPY

Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

(2010) Sonia Guedan et al.   MOLECULAR THERAPY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

(2009) E. S. Seeley et al.   CANCER RESEARCH

Synergism from combined immunologic and pharmacologic inhibition of HER2in vivo

(2009) Michael A. Morse et al.   INTERNATIONAL JOURNAL OF CANCER

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

(2008) A. Nocito et al.   CANCER RESEARCH

Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality

(2008) Jae-Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine