Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide

Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems

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Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

The HSP90 chaperone machinery

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Chemical labelling for visualizing native AMPA receptors in live neurons

(2017) Sho Wakayama et al.   Nature Communications

Targeted Covalent Inhibitors for Drug Design

(2016) Thomas A. Baillie   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry

(2016) Kei Yamaura et al.   Nature Chemical Biology

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

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Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

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Prolonged and tunable residence time using reversible covalent kinase inhibitors

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PU-H71: An improvement on nature's solutions to oncogenic Hsp90 addiction

(2015) Matthew Trendowski   PHARMACOLOGICAL RESEARCH

Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins

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Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

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Ligand-directed tosyl chemistry for in situ native protein labeling and engineering in living systems: from basic properties to applications

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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

(2014) Bryan R Lanning et al.   Nature Chemical Biology

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

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Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems

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Bioorthogonal chemistry: strategies and recent developments

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Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

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Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

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Fluorophore Labeling of Native FKBP12 by Ligand-Directed Tosyl Chemistry Allows Detection of Its Molecular Interactions in Vitro and in Living Cells

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Iminoboronates: A New Strategy for Reversible Protein Modification

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Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Live Cells

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Native FKBP12 Engineering by Ligand-Directed Tosyl Chemistry: Labeling Properties and Application to Photo-Cross-Linking of Protein Complexes in Vitro and in Living Cells

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The resurgence of covalent drugs

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Chemoenzymatic methods for site-specific protein modification

(2010) David Rabuka   CURRENT OPINION IN CHEMICAL BIOLOGY

ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90

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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

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Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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Relative Quantification of Proteins in Human Cerebrospinal Fluids by MS/MS Using 6-Plex Isobaric Tags

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An Engineered Protein Tag for Multiprotein Labeling in Living Cells

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