Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry

Monitoring Ligand-Induced Conformational Changes for the Identification of Estrogen Receptor Agonists and Antagonists

(2015) Svenja C. Mayer-Wrangowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Progress in Design of Protein-Based Fluorescent Biosensors and Their Cellular Applications

(2014) Tomonori Tamura et al.   ACS Chemical Biology

Relative Positioning of Classical Benzodiazepines to the γ2-Subunit of GABAA Receptors

(2014) Simon J. Middendorp et al.   ACS Chemical Biology

High-Throughput Development of a Hybrid-Type Fluorescent Glutamate Sensor for Analysis of Synaptic Transmission

(2014) Kenji Takikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions

(2014) Takayuki Miki et al.   CHEMISTRY & BIOLOGY

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor

(2013) David C. Chiara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Detection of Allosteric Phosphatase Inhibitors

(2013) Ralf Schneider et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A propofol binding site on mammalian GABAA receptors identified by photolabeling

(2013) Grace M S Yip et al.   Nature Chemical Biology

Converting a Solvatochromic Fluorophore into a Protein-Based pH Indicator for Extreme Acidity

(2012) Maiyun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic

(2012) Pavel Y. Savechenkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Semisynthetic Fluorescent Sensor Protein for Glutamate

(2012) Matthias A. Brun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Fluorescent Sensor for GABA and Synthetic GABAB Receptor Ligands

(2012) Anastasiya Masharina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Live Cells

(2012) Sho-hei Fujishima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

(2012) Lars Richter et al.   Nature Chemical Biology

Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis

(2012) Simon Oakley et al.   PLoS One

Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects

(2011) Suengmok Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and evaluation of highly potent GABAA receptor antagonists based on gabazine (SR-95531)

(2011) Favaad Iqbal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts

(2011) Hangxiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

An In Vivo Fluorescent Sensor Reveals Intracellular Ins(1,3,4,5)P4Dynamics in Single Cells

(2009) Reiko Sakaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

(2009) J. R. Atack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Conformation of Receptor Adopted upon Interaction with Virus Revealed by Site-Specific Fluorescence Quenchers and FRET Analysis

(2009) Jürgen Wruss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Semisynthetic Fluorescent Sensor Proteins Based on Self-Labeling Protein Tags

(2009) Matthias A. Brun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α

(2009) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors

(2009) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Structural Mechanisms Underlying Benzodiazepine Modulation of the GABAA Receptor

(2008) S. M. Hanson et al.   JOURNAL OF NEUROSCIENCE

The Clustering of GABAA Receptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor  2 Subunits to Gephyrin

(2008) V. Tretter et al.   JOURNAL OF NEUROSCIENCE

Recognition-Domain Focused Chemosensors: Versatile and Efficient Reporters of Protein Kinase Activity

(2008) Elvedin Luković et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY