PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
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Title
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
Authors
Keywords
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Journal
NATURE MEDICINE
Volume 22, Issue 4, Pages 379-387
Publisher
Springer Nature
Online
2016-03-14
DOI
10.1038/nm.4062
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- Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells
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- Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
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