A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

Genomic spectra of biliary tract cancer

(2015) Hiromi Nakamura et al.   NATURE GENETICS

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

(2015) Akihiro Fujimoto et al.   Nature Communications

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

(2015) Michele Simbolo et al.   Oncotarget

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

(2014) J. S. Ross et al.   ONCOLOGIST

Mutational landscape of intrahepatic cholangiocarcinoma

(2014) Shanshan Zou et al.   Nature Communications

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas

(2013) Steffen Zender et al.   CANCER CELL

Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma

(2013) R. V. Guest et al.   CANCER RESEARCH

Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma

(2013) Sumera Rizvi et al.   GASTROENTEROLOGY

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies

(2013) Victoria Marsh et al.   JOURNAL OF PATHOLOGY

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

KrasG12D and p53 Mutation Cause Primary Intrahepatic Cholangiocarcinoma

(2012) M. R. O'Dell et al.   CANCER RESEARCH

Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes

(2012) Mina Komuta et al.   HEPATOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

CpG-island methylation study of liver fluke-related cholangiocarcinoma

(2011) R Sriraksa et al.   BRITISH JOURNAL OF CANCER

The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E. Sirica   Nature Reviews Gastroenterology & Hepatology

High incidence of ras gene mutation in intrahepatic cholangiocarcinoma

(2010) Minoru Tada et al.   CANCER

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

(2009) Florin M. Selaru et al.   HEPATOLOGY

Cholangiocarcinoma

(2008) Boris R.A. Blechacz et al.   Clinics in Liver Disease

A CK19CreERTknockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs

(2008) Anna L. Means et al.   GENESIS